Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: Implication for neuroprotective therapies [PDF]
, 2013 Neuroprotective therapies based on brain-derived neurotrophic factor (BDNF) administration have been proposed for Huntington's disease (HD) treatment. However, our group has recently reported reduced levels of TrkB in HD mouse models and HD human brain ...
Alberch, J. +5 more
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Frontiers in Neuroanatomy, 2012 Previous research has suggested that the three physiologically-defined relay cell types in mammalian lateral geniculate nucleus (LGN) – called parvocellular (P), magnocellular (M), and koniocellular (K) cells in primates and X, Y, and W cells in other ...
Daniel L Felch, Stephen D Van Hooser
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Functional and Molecular Analysis of Proprioceptive Sensory Neuron Excitability in Mice
Frontiers in Molecular Neuroscience, 2020 Neurons located in dorsal root ganglia (DRG) are crucial for transmitting peripheral sensations such as proprioception, touch, temperature, and nociception to the spinal cord before propagating these signals to higher brain structures.
Jessica F. Madden +16 more
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Cortical and Striatal Circuits in Huntington's Disease
, 2020 Huntington's disease (HD) is a hereditary neurodegenerative disorder that typically manifests in midlife with motor, cognitive, and/or psychiatric symptoms.
Blumenstock, S., Dudanova, I.
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Neurochemical characterisation of lamina II inhibitory interneurons that express GFP in the PrP-GFP mouse [PDF]
, 2013 Background Inhibitory interneurons in the superficial dorsal horn play important roles in modulating sensory transmission, and these roles are thought to be performed by distinct functional populations. We have identified 4 non-overlapping classes among
Garzillo, F. +4 more
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Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice
Nature CommunicationsThe hippocampus is the brain’s center for episodic memories. Its subregions, the dentate gyrus and CA1-3, are differentially involved in memory encoding and recall. Hippocampal principal cells represent episodic features like movement, space, and context,
Thomas Hainmueller +3 more
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SAT1, a glutamine transporter, is preferentially expressed in GABAergic neurons
Frontiers in Neuroanatomy, 2010 Subsets of GABAergic neurons are able to maintain high frequency discharge patterns, which requires efficient replenishment of the releasable pool of GABA.
Tom Tallak Solbu +8 more
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What causes aberrant salience in schizophrenia? A role for impaired short-term habituation and the GRIA1 (GluA1) AMPA receptor subunit. [PDF]
, 2014 The GRIA1 locus, encoding the GluA1 (also known as GluRA or GluR1) AMPA glutamate receptor subunit, shows genome-wide association to schizophrenia. As well as extending the evidence that glutamatergic abnormalities have a key role in the disorder, this ...
Bannerman, D.M. +5 more
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Mapping alterations in the local synchrony of the cerebral cortex in schizophrenia
European Psychiatry, 2023 Background Observations from different fields of research coincide in indicating that a defective gamma-aminobutyric acid (GABA) interneuron system may be among the primary factors accounting for the varied clinical expression of schizophrenia.
Jesus Pujol +6 more
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Age-related neurochemical changes in the rhesus macaque inferior colliculus.
Frontiers in Aging Neuroscience, 2014 Age-related hearing loss (ARHL) is marked by audiometric hearing deficits that propagate along the auditory pathway. Neurochemical changes as a function of aging have also been identified in neurons along the auditory pathway in both rodents and ...
James eEngle +6 more
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