Results 61 to 70 of about 55,623 (223)

Post-mortem human brain analysis of the ventral pallidum in alcohol use disorder

Addiction Neuroscience
Objective: Alcohol use disorder (AUD) is characterised by cycles of alcohol misuse, abstinence, and relapse. The neurobiology of AUD strongly implicates the role of the ventral pallidum (VP) in a variety of drugs of abuse, including alcohol. Pre-clinical
Ameer Elena Rasool, Cormac Peat, Jie Liu, Greg Sutherland, Asheeta A. Prasad   +4 more
doaj   +1 more source

Parvalbumin Interneuron Activation-Dependent Adult Hippocampal Neurogenesis Is Required for Treadmill Running to Reverse Schizophrenia-Like Phenotypes

Frontiers in Cell and Developmental Biology, 2020
Physical exercise can alleviate some of the schizophrenia symptoms in patients, the mechanisms, however, are still unclear. To investigate whether the GABAergic interneuron involved in the therapeutic effect of treadmill running on schizophrenia, the ...
Yandong Yi, Yandong Yi, Yuanlong Song, Yuanlong Song, Yisheng Lu, Yisheng Lu   +5 more
doaj   +1 more source

Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible.

Nature Neuroscience, 2018
To uncover the circuit-level alterations that underlie atypical sensory processing associated with autism, we adopted a symptom-to-circuit approach in the Fmr1-knockout (Fmr1–/–) mouse model of Fragile X syndrome.
Anubhuti Goel, Daniel A. Cantu, Janna Guilfoyle, Gunvant R. Chaudhari, Aditi Newadkar, Barbara Todisco, Diego de Alba, Nazim Kourdougli, Lauren M. Schmitt, E. Pedapati, C. Erickson, C. Portera-Cailliau   +11 more
semanticscholar   +1 more source

Hominoid‐specific calretinin‐immunopositivity of the optic radiation (geniculocalcarine tract)

The Anatomical Record, EarlyView.
Calretinin‐immunostained coronal section through the primary (V1) and extrastriate (ExSt) cortex of the lar gibbon. Note that the optic radiation (OR) is strongly calretinin‐immunoreactive. This calretinin‐immunopositivity of the OR distinguishes the Hominoidea from other primates in terms of the neurochemistry of the OR.
Nelyane N. M. Santana, Jordan Swiegers, Mads F. Bertelsen, Chet C. Sherwood, José R. L. P. Cavalcanti, Paul R. Manger   +5 more
wiley   +1 more source

The segregation of Calb1, Calb2, and Prph neurons reveals distinct and mixed neuronal populations and projections to hair cells in the inner ear and central nuclei

Developmental Dynamics, EarlyView.
Three populations of hair cells have a distinct expression of Calb1 and Calb2. (A, A′D) The central is highly positive for Calb1 while surrounding HC are positive for Calb2. Later, a calyx forms primarily with Calb1. (B, B′, D′, D″) Saccule and utricle start out positive for Calb2 but will upregulate the Calb1 in the striola that is primarily forming ...
Jeong Han Lee, Ebenezer N. Yamoah, Jennifer Kersigo, Karen Elliott, Niya LaRoda, Gabriela Pavlinkova, Bernd Fritzsch   +6 more
wiley   +1 more source

Molecular compartmentalization of lateral geniculate nucleus in the gray squirrel (Sciurus carolinensis)

Frontiers in Neuroanatomy, 2012
Previous research has suggested that the three physiologically-defined relay cell types in mammalian lateral geniculate nucleus (LGN) – called parvocellular (P), magnocellular (M), and koniocellular (K) cells in primates and X, Y, and W cells in other ...
Daniel L Felch, Stephen D Van Hooser
doaj   +1 more source

Functional and Molecular Analysis of Proprioceptive Sensory Neuron Excitability in Mice

Frontiers in Molecular Neuroscience, 2020
Neurons located in dorsal root ganglia (DRG) are crucial for transmitting peripheral sensations such as proprioception, touch, temperature, and nociception to the spinal cord before propagating these signals to higher brain structures.
Jessica F. Madden, Jessica F. Madden, Olivia C. Davis, Kieran A. Boyle, Jacqueline A. Iredale, Jacqueline A. Iredale, Tyler J. Browne, Tyler J. Browne, Robert J. Callister, Robert J. Callister, Douglas W. Smith, Douglas W. Smith, Phillip Jobling, Phillip Jobling, David I. Hughes, Brett A. Graham, Brett A. Graham   +16 more
doaj   +1 more source

Decoding epilepsy's molecular blueprint: Machine learning unravels transcriptomic subtypes and regulatory networks

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy. The molecular heterogeneity underlying DRE remains poorly defined, largely due to limited access to resected brain tissue and substantial genetic diversity.
Yanping Weng, Yu Ma, Wanwan Hou, Haibo Li, Yuanfeng Zhou, Rui Zhao, Hao Li, Lian Chen, Yangyang Ma, Li Jin, Yi Wang, Yu An   +11 more
wiley   +1 more source

Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice

Nature Communications
The hippocampus is the brain’s center for episodic memories. Its subregions, the dentate gyrus and CA1-3, are differentially involved in memory encoding and recall. Hippocampal principal cells represent episodic features like movement, space, and context,
Thomas Hainmueller, Aurore Cazala, Li-Wen Huang, Marlene Bartos   +3 more
doaj   +1 more source

SAT1, a glutamine transporter, is preferentially expressed in GABAergic neurons

Frontiers in Neuroanatomy, 2010
Subsets of GABAergic neurons are able to maintain high frequency discharge patterns, which requires efficient replenishment of the releasable pool of GABA.
Tom Tallak Solbu, Tom Tallak Solbu, Mona Bjørkmo, Mona Bjørkmo, Paul Berghuis, Tibor Harkany, Tibor Harkany, Farrukh A Chaudhry, Farrukh A Chaudhry   +8 more
doaj   +1 more source