Frontiers in Immunology, 2023 Pattern recognition receptors are primitive sensors that arouse a preconfigured immune response to broad stimuli, including nonself pathogen-associated and autologous damage-associated molecular pattern molecules.
Tian Wang +6 more
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Hyperconservation of the N -Formyl Peptide Binding Site of M3 : Evidence that M3 Is an Old Eutherian Molecule with Conserved Recognition of a Pathogen-Associated Molecular Pattern [PDF]
The Journal of Immunology, 2003 Abstract The mouse MHC class I-b molecule H2-M3 has unique specificity for N-formyl peptides, derived from bacteria (and mitochondria), and is thus a pathogen-associated molecular pattern recognition receptor (PRR). To test whether M3 was selected for this PRR function, we studied M3 sequences from diverse murid species of murine ...
C Kuyler Doyle +4 more
openaire +1 more source
Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation
Cells, 2021 High mobility group box 1 protein (HMGB1), a highly conserved nuclear DNA-binding protein, is a “damage-associated molecular pattern” molecule (DAMP) implicated in both stimulating and inhibiting innate immunity.
Ulf Andersson +2 more
doaj +1 more source
International Journal of Immunopathology and Pharmacology, 2021 Introduction Nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3), an intracellular pattern recognition receptor, recognizes various pathogen-associated molecular pattern and/or damage-associated molecular ...
Wakako Mori +4 more
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Receptor-like kinases and pathogen-associated molecular patterns perception in Arabidopsis [PDF]
, 2006 Comparable to the innate immune response in mammals and insects, plants possess highly specific and sensitive recognition systems for pathogen-associated molecular patterns (PAMPs), such as bacterial flagellin.
Zipfel, Cyril
core +1 more source
Helicobacter pylori Pathogen-Associated Molecular Patterns: Friends or Foes?
, 2022 Microbial infections are sensed by the host immune system by recognizing signature molecules called Pathogen-Associated Molecular Patterns—PAMPs. The binding of these biomolecules to innate immune receptors, called Pattern Recognition Receptors (PRRs ...
Amalia Porta +11 more
core +1 more source
Therapeutic Interventions into Innate Immune Diseases by Means of Aptamers
Pharmaceutics, 2020 The immune system plays a crucial role in the body’s defense system against various pathogens, such as bacteria, viruses, and parasites, as well as recognizes non-self- and self-molecules.
Farzana Yasmeen +4 more
doaj +1 more source
Nuclear processes associated with plant immunity and pathogen susceptibility [PDF]
, 2015 Plants are sessile organisms that have evolved exquisite and sophisticated mechanisms to adapt to their biotic and abiotic environment. Plants deploy receptors and vast signalling networks to detect, transmit and respond to a given biotic threat by ...
Kulagina, Natalja +3 more
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Innate Immune Recognition: An Issue More Complex Than Expected
Frontiers in Cellular and Infection Microbiology, 2019 Primary interaction of an intracellular bacterium with its host cell is initiated by activation of multiple signaling pathways in response to bacterium recognition itself or as cellular responses to stress induced by the bacterium.
Klara Kubelkova, Ales Macela
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Formin nanoclustering-mediated actin assembly during plant flagellin and DSF signaling
Cell Reports, 2021 Summary: Plants respond to bacterial infection acutely with actin remodeling during plant immune responses. The mechanisms by which bacterial virulence factors (VFs) modulate plant actin polymerization remain enigmatic.
Zhiming Ma +7 more
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