Results 51 to 60 of about 221,631 (251)

NLRP3: Role in ischemia/reperfusion injuries

Frontiers in Immunology, 2022
NLR family pyrin domain containing 3 (NLRP3) is expressed in immune cells, especially in dendritic cells and macrophages and acts as a constituent of the inflammasome.
Soudeh Ghafouri-Fard, Hamed Shoorei, Hamed Shoorei, Yadollah Poornajaf, Bashdar Mahmud Hussen, Bashdar Mahmud Hussen, Yasaman Hajiesmaeili, Atefe Abak, Mohammad Taheri, Mohammad Taheri, Ahmad Eghbali   +10 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Stage-Specific Suppression of Basal Defense Discriminates Barley Plants Containing Fast- and Delayed-Acting Mla Powdery Mildew Resistance Alleles

Molecular Plant-Microbe Interactions, 2006
Nonspecific recognition of pathogen-derived general elicitors triggers the first line of plant basal defense, which in turn, preconditions the host towards resistance or susceptibility. To elucidate how basal defense responses influence the onset of Mla (
Rico A. Caldo, Dan Nettleton, Jiqing Peng, Roger P. Wise   +3 more
doaj   +1 more source

Effect of β-Mannanase Addition during Whole Pigs Fattening on Production Yields and Intestinal Health

Animals, 2022
The presence of β-mannans in feed can produce a futile and chronic immune stimulation in fattening pigs. In this trial, a 1-4-endo-D-β-mannanase was added to the feed (HC) during growth and fattening (0.03% of Hemicell HT) and physical performance and ...
Pedro Sánchez-Uribe, Eva Romera-Recio, Carolina G. Cabrera-Gómez, Elisa V. Hernández-Rodríguez, Álvaro Lamrani, Belén González-Guijarro, Clara de Pascual-Monreal, Livia Mendonça-Pascoal, Laura Martínez-Alarcón, Guillermo Ramis   +9 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

PAMPs of Piscirickettsia salmonis Trigger the Transcription of Genes Involved in Nutritional Immunity in a Salmon Macrophage-Like Cell Line

Frontiers in Immunology, 2022
The innate immune system can limit the growth of invading pathogens by depleting micronutrients at a cellular and tissue level. However, it is not known whether nutrient depletion mechanisms discriminate between living pathogens (which require nutrients)
Danixa Pamela Martínez, Danixa Pamela Martínez, Cristian Oliver, Natacha Santibañez, José Leonardo Coronado, Ricardo Oyarzún-Salazar, Ricardo Enriquez, Luis Vargas-Chacoff, Luis Vargas-Chacoff, Luis Vargas-Chacoff, Alex Romero, Alex Romero   +11 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes

Frontiers in Immunology, 2021
EMR2/ADGRE2 is an adhesion G protein-coupled receptor differentially expressed by human myeloid cells. It modulates diverse cellular functions of innate immune cells and a missense EMR2 variant is directly responsible for vibratory urticaria.
Kuan-Yu I, Wen-Yi Tseng, Wen-Chih Wang, Siamon Gordon, Siamon Gordon, Kwai-Fong Ng, Hsi-Hsien Lin, Hsi-Hsien Lin, Hsi-Hsien Lin   +8 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source