Results 11 to 20 of about 210,770 (100)

The Fungal Pathogen Candida glabrata Does Not Depend on Surface Ferric Reductases for Iron Acquisition

Frontiers in Microbiology, 2017
Iron acquisition is a crucial virulence determinant for many bacteria and fungi, including the opportunistic fungal pathogens Candida albicans and C. glabrata. While the diverse strategies used by C.
Franziska Gerwien, Abu Safyan, Stephanie Wisgott, Sascha Brunke, Lydia Kasper, Bernhard Hube, Bernhard Hube, Bernhard Hube   +7 more
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Bhalin, an Essential Cytoskeleton-Associated Protein of Trypanosoma brucei Linking TbBILBO1 of the Flagellar Pocket Collar with the Hook Complex

Microorganisms, 2021
Background: In most trypanosomes, endo and exocytosis only occur at a unique organelle called the flagellar pocket (FP) and the flagellum exits the cell via the FP.
Christine E. Broster Reix, Célia Florimond, Anne Cayrel, Amélie Mailhé, Corentin Agnero-Rigot, Nicolas Landrein, Denis Dacheux, Katharina Havlicek, Mélanie Bonhivers, Brooke Morriswood, Derrick R. Robinson   +10 more
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Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration

Retrovirology, 2017
Background Insertion of retroviral genome DNA occurs in the chromatin of the host cell. This step is modulated by chromatin structure as nucleosomes compaction was shown to prevent HIV-1 integration and chromatin remodeling has been reported to affect ...
Julien Matysiak, Paul Lesbats, Eric Mauro, Delphine Lapaillerie, Jean-William Dupuy, Angelica P. Lopez, Mohamed Salah Benleulmi, Christina Calmels, Marie-Line Andreola, Marc Ruff, Manuel Llano, Olivier Delelis, Marc Lavigne, Vincent Parissi   +13 more
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Retroviral integration site selection: a running Gag?

Microbial Cell, 2018
The ability of retroviruses to integrate their genomes into host chromatin is a key step for the completion of their replication cycle. Selection of a suitable chromosomal integration site has been described as a hierarchical mechanism involving both ...
Paul Lesbats, Vincent Parissi
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The Dual Function of the Fungal Toxin Candidalysin during Candida albicans—Macrophage Interaction and Virulence

Toxins, 2020
The dimorphic fungus Candida albicans is both a harmless commensal organism on mucosal surfaces and an opportunistic pathogen. Under certain predisposing conditions, the fungus can overgrow the mucosal microbiome and cause both superficial and life ...
Annika König, Bernhard Hube, Lydia Kasper   +2 more
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Chemical Characterization and Leishmanicidal Activity In Vitro and In Silico of Natural Products Obtained from Leaves of Vernonanthura brasiliana (L.) H. Rob (Asteraceae)

Metabolites, 2023
Vernonanthura brasiliana (L.) H. Rob is a medicinal plant used for the treatment of several infections. This study aimed to evaluate the antileishmanial activity of V. brasiliana leaves using in vitro and in silico approaches. The chemical composition of
Yuri Nascimento Fróes, João Guilherme Nantes Araújo, Joyce Resende dos Santos Gonçalves, Milena de Jesus Marinho Garcia de Oliveira, Gustavo Oliveira Everton, Victor Elias Mouchrek Filho, Maria Raimunda Chagas Silva, Luís Douglas Miranda Silva, Lucilene Amorim Silva, Lídio Gonçalves Lima Neto, Renata Mondêgo de Oliveira, Mylena Andréa Oliveira Torres, Luís Cláudio Nascimento da Silva, Alberto Jorge Oliveira Lopes, Amanda Silva dos Santos Aliança, Cláudia Quintino da Rocha, Joicy Cortez de Sá Sousa   +16 more
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A Novel Hybrid Iron Regulation Network Combines Features from Pathogenic and Nonpathogenic Yeasts

mBio, 2016
Iron is an essential micronutrient for both pathogens and their hosts, which restrict iron availability during infections in an effort to prevent microbial growth.
Franziska Gerwien, Abu Safyan, Stephanie Wisgott, Fabrice Hille, Philipp Kaemmer, Jörg Linde, Sascha Brunke, Lydia Kasper, Bernhard Hube   +8 more
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Candidalysin Is the Hemolytic Factor of Candida albicans

Toxins, 2022
Candida albicans produces an important virulence factor, the hypha-associated Ece1-derived secreted peptide toxin candidalysin, which is crucial for the establishment of mucosal and systemic infections. C.
Selene Mogavero, Sarah Höfs, Alexa N. Lauer, Rita Müller, Sascha Brunke, Stefanie Allert, Franziska Gerwien, Sabrina Groth, Edward Dolk, Duncan Wilson, Thomas Gutsmann, Bernhard Hube   +11 more
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Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity

Nature Communications, 2022
Commensal bacteria such as Lactobacillus rhamnosus can inhibit the pathogenicity of the fungus Candida albicans. Here, Alonso-Roman et al. investigate the interplay between C. albicans, L.
Raquel Alonso-Roman, Antonia Last, Mohammad H. Mirhakkak, Jakob L. Sprague, Lars Möller, Peter Großmann, Katja Graf, Rena Gratz, Selene Mogavero, Slavena Vylkova, Gianni Panagiotou, Sascha Schäuble, Bernhard Hube, Mark S. Gresnigt   +13 more
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Antibiotics as a Stressing Factor Triggering the Harboring of Helicobacter pylori J99 within Candida albicans ATCC10231

Pathogens, 2021
First-line treatment for Helicobacter pylori includes amoxicillin and clarithromycin or metronidazole plus a proton pump inhibitor. Treatment failure is associated with antibiotic resistance and possibly also with internalization of H.
Kimberly Sánchez-Alonzo, Libnny Belmar, Cristian Parra-Sepúlveda, Humberto Bernasconi, Víctor L. Campos, Carlos T. Smith, Katia Sáez, Apolinaria García-Cancino   +7 more
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