Results 131 to 140 of about 35,228 (288)

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Patient-derived ovarian cancer models demonstrate the influence of tumor-associated macrophages on therapeutic response

OncoImmunology
While most ovarian cancer (OC) patients respond to front-line platinum/taxane chemotherapy and surgical debulking, the majority will develop platinum-resistance and recur.
Parisa Nikeghbal, Danielle Burke, Dalet Armijo, Samuel Aldarondo-Quiñones, Diane S. Lidke, Mara P. Steinkamp   +5 more
doaj   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Patient-Derived Tumor Organoids: A Promising Tool for Personalized Cancer Therapy

Journal of Carcinogenesis & Mutagenesis, 2018
Patient Derived Organoids (PDOs) are described as miniature, three dimensional (3D) cell cultures prepared from patient’s cancer cell to compare therapeutic responses in the laboratory and clinical settings. Personalized cancer medicine is a novel therapeutic strategy to identify a right treatment for the right patient in accordance with tumor’s ...
Divya Sasidharan Padmaja, Pratheeshkumar Poyil   +1 more
openaire   +1 more source

Phase Separation of NFIB Suppresses SLC3A2‐Mediated Ferroptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li, Danyang Chen, Yongzhen Xia, Yili Long, Nan Huang, Rongna Li, Mengting Shi, Mairehaba Kadier, Huafeng Luo, Xiaohui Chen, Hao Liu, Guanmin Jiang   +11 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Patient-derived organoids from normal and tumoral colorectal tissue

, 2019
Resumen del póster presentado al 42nd Congress of the Spanish Society of Biochemistry and Molecular Biology (SEBBM), celebrado en Madrid del 16 al 19 de julio de 2019. Colon and rectum are part of the same organ but have different embryological, anatomical and physiological characteristics.
Costales-Carrera, Alba, Bustamante-Madrid, Pilar, Burgos, Aurora, Barbáchano, Antonio, Muñoz Terol, Alberto, Fernández-Barral, A.   +5 more
openaire   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Case report: Patient-derived organoids promoting personalized treatment in invasive urothelial carcinoma

Frontiers in Oncology
Tumor organoids, an in-vitro three-dimensional model, possess high potential for investigating tumor biology and treatment response and have been demonstrated more appropriate for drug assessment than two-dimensional cultures.
Xun Liu, Xuebing Han, Shuqing Wei, Changwen Zhang   +3 more
doaj   +1 more source

Patient-Derived Meningioma Organoids: A Reliable Model for Studying Human Tumor Pathophysiology

Cancers
Introduction: Meningiomas are the most common primary central nervous system tumors, constituting 39.7% of intracranial tumors. Although generally benign, some exhibit aggressive behavior and risk of recurrence, necessitating adjuvant therapy and repeat surgical interventions.
Youssef M. Zohdy, Arman Jahangiri, Fadi Jacob, Aliaksandr Aksionau, Ali M. Alawieh, Amelia Tong, Bethany Chern, Justin Maldonado, Kimberly Hoang, Edjah Nduom, Brian M. Howard, Daniel L. Barrow, Stewart G. Neill, Zhexing Wen, Gustavo Pradilla, Tomas Garzon-Muvdi   +15 more
openaire   +2 more sources