Results 131 to 140 of about 689,097 (325)

Urokinase-Type Plasminogen Activator Promotes Paracellular Transmigration of Neutrophils Via Mac-1, But Independently of Urokinase-Type Plasminogen Activator Receptor [PDF]

, 2011
Background: Urokinase-type plasminogen activator (uPA) has recently been implicated in the pathogenesis of ischemia-reperfusion (I/R) injury. The underlying mechanisms remain largely unclear.
Paul J. Declerck, Rehberg, Markus, Daniel Puhr-Westerheide, Lerchenberger, Max, Uhl, Bernd, Kanse, Sandip, Johanna Liebl, Reichel, Christoph A., Bernd Uhl, Markus Rehberg, Zahler, Stefan, Lorenzl, Stefan, Elisabeth Deindl, Khandoga, Andrej, Declerck, Paul J., Stefan Zahler, Schmalix, Wolfgang, Fritz Krombach, Liebl, Johanna, Christoph A. Reichel, Krombach, Fritz, Max Lerchenberger, Andrej Khandoga, Stefan Lorenzl, Deindl, Elisabeth, Wolfgang Schmalix, Puhr-Westerheide, Daniel, Sandip Kanse   +27 more
core   +1 more source

Comparative genome analysis reveals an absence of leucine-rich repeat pattern-recognition receptor proteins in the kingdom Fungi.

PLoS ONE, 2010
BackgroundIn plants and animals innate immunity is the first line of defence against attack by microbial pathogens. Specific molecular features of bacteria and fungi are recognised by pattern recognition receptors that have extracellular domains ...
Darren M Soanes, Nicholas J Talbot
doaj   +1 more source

Ligand-induced endocytosis of the pattern recognition receptor FLS2 in Arabidopsis.

Genes & Development, 2006
Pattern-recognition receptors (PRRs) trigger innate immune responses in animals and plants. One such PRR is the flagellin receptor FLS2 in Arabidopsis. Here, we demonstrate that a functional fusion of FLS2 to the green fluorescent protein (GFP) resides ...
S. Robatzek, D. Chinchilla, T. Boller
semanticscholar   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Pattern-recognition receptors and recognition of pathogens

Journal of Medicine and Life Science, 2009
The mammalian host has evolved innate immune strategies to detect and respond to rapidly to diverse group of microorganisms. Microbial recognition is achieved by pattern-recognition receptors (PRRs) such as toll-like receptors (TLRs) and Nod-like receptor (NLRs).
openaire   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Transgenic expression of the rice Xa21 pattern recognition receptor in banana (Musa sp.) confers resistance to Xanthomonas campestris pv. musacearum

Plant Biotechnology Journal, 2014
Summary Banana Xanthomonas wilt (BXW), caused by the bacterium Xanthomonas campestris pv. musacearum (Xcm), is the most devastating disease of banana in east and central Africa.
Jaindra Nath Tripathi, J. Lorenzen, Ofir Bahar, P. Ronald, L. Tripathi   +4 more
semanticscholar   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

MOESM1 of Clearance of Cell Remnants and Regeneration of Injured Muscle Depend on Soluble Pattern Recognition Receptor PTX3

, 2018
Clearance of Cell Remnants and Regeneration of Injured Muscle Depend on Soluble Pattern Recognition Receptor ...
Alberto Mantovani (287283), Michela Vezzoli (388380), Antonella Monno (388379), Clara Sciorati (49426), Angelo Manfredi (3438701), Annalisa Capobianco (262875), Gianfranca Corna (748890), Elena Rigamonti (748891), Alessandra Castiglioni (748889), Patrizia Rovere-Querini (155882), Lara Campana (155957), Maria Doglio (5816444), Thierry Touvier (142439), Cecilia Garlanda (291677)   +13 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source