Results 91 to 100 of about 19,461 (219)
Prediction of gene–phenotype associations in humans, mice, and plants using phenologs [PDF]
All authors are with the Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA.
Laurent, Jon M. +4 more
core +2 more sources
Clinicopathological Characteristics and Outcomes of Genitourinary Rhabdomyosarcoma in Two Girls
ABSTRACT Rhabdomyosarcoma (RMS) is a soft tissue neoplasm accounting for about 8% of solid tumors in children. There are mainly four histologic subtypes of RMS: embryonal, alveolar, spindle cell/sclerosing, and pleomorphic. The genitourinary tract is the second most affected primary site of RMS. Genitourinary RMS is more common in young boys than girls.
George Evele +3 more
wiley +1 more source
Melanoma is a very aggressive neoplasm with a propensity to undergo progression and invasion early in its evolution. The molecular pathways underpinning invasion in melanoma are now just beginning to be elucidated, but a clear understanding of the ...
Michael R Eccles +6 more
doaj +1 more source
Pax3 expression enhances PDGF-B-induced brainstem gliomagenesis and characterizes a subset of brainstem glioma [PDF]
High-grade Brainstem Glioma (BSG), also known as Diffuse Intrinsic Pontine Glioma (DIPG), is an incurable pediatric brain cancer. Increasing evidence supports the existence of regional differences in gliomagenesis such that BSG is considered a distinct ...
Baker, Suzanne J. +7 more
core +3 more sources
Abstract Background Midline establishment is a fundamental process during early embryogenesis for Bilaterians. Midline morphogenesis in non‐amniotes can occur without mitosis, through Planar Cell Polarity (PCP) signaling. By contrast, amniotes utilize both cellular processes for developing the early midline landmark, the primitive streak (PS).
Zhiling Zhao, Rieko Asai, Takashi Mikawa
wiley +1 more source
Human Umbilical Vein Endothelial Cells Express the DUX4 Protein: A Basis for Further Vascular Research [PDF]
Objective: A growing body of evidence suggests a correlation between endothelial cell dysfunction and cancer, as well as facioscapulohumeral dystrophy, both of which are DUX4-related diseases. However, the endogenous expression of DUX4 within endothelial
Ceren HANGUL +5 more
doaj +1 more source
PAX Genes in Cancer; Friends or Foes? [PDF]
PAX genes have been shown to be critically required for the development of specific tissues and organs during embryogenesis. In addition, PAX genes are expressed in a handful of adult tissues where they are thought to play important roles, usually ...
Caiyun G. Li, Michael R. Eccles
core +1 more source
Genome-wide association study in two cohorts from a multi-generational mouse advanced intercross line highlights the difficulty of replication due to study-specific heterogeneity [PDF]
There has been extensive discussion of the Replication Crisis in many fields, including genome-wide association studies
Cheng, Riyan +7 more
core +2 more sources
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du +17 more
wiley +1 more source

