Results 81 to 90 of about 10,442 (179)

Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures

Skeletal Muscle, 2017
Background Facioscapulohumeral muscular dystrophy (FSHD) is most commonly inherited in an autosomal dominant pattern and caused by the abnormal expression of DUX4 in skeletal muscle.
Premi Haynes, Kelly Kernan, Suk-Lin Zhou, Daniel G. Miller   +3 more
doaj   +1 more source

Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mesoderm.

PLoS Biology, 2019
The transcriptional mechanisms driving lineage specification during development are still largely unknown, as the interplay of multiple transcription factors makes it difficult to dissect these molecular events.
Alessandro Magli, June Baik, Lauren J Mills, Il-Youp Kwak, Bridget S Dillon, Ricardo Mondragon Gonzalez, David A Stafford, Scott A Swanson, Ron Stewart, James A Thomson, Daniel J Garry, Brian D Dynlacht, Rita C R Perlingeiro   +12 more
doaj   +1 more source

Phosphorylation of Ser205 by Casein kinase II persists on Pax3‐FOXO1a, but not Pax3, throughout myogenic differentiation

The FASEB Journal, 2009
The myogenic transcription factor Pax3 plays an essential role in early skeletal muscle development and is a key factor in Alveolar rhabdomyosarcoma (ARMS), a childhood solid muscle tumor. ARMS is associated with an unfavorable prognosis due to the propensity for wide dissemination and a poor response to ...
Kevin N. Dietz, Patrick J. Miller, Andrew D. Hollenbach   +2 more
openaire   +1 more source

Dual inhibition of KDM4B and KDM5A disassembles the PAX3-FOXO1 transcriptional program in fusion-positive rhabdomyosarcoma

Biology Direct
Background Fusion-positive rhabdomyosarcoma (FP-RMS) is driven by the oncogenic transcription factor PAX3-FOXO1 and is associated with poor clinical outcome.
Junhong Yuan, Qilei Han, Pengxuan Ren, Fang Bai, Xianglei Zhang, Kai Li   +5 more
doaj   +1 more source

Regulatory landscape fusion in rhabdomyosarcoma through interactions between the PAX3 promoter and FOXO1 regulatory elements

Genome Biology, 2017
Background The organisation of vertebrate genomes into topologically associating domains (TADs) is believed to facilitate the regulation of the genes located within them.
Cristina Vicente-García, Barbara Villarejo-Balcells, Ibai Irastorza-Azcárate, Silvia Naranjo, Rafael D. Acemel, Juan J. Tena, Peter W. J. Rigby, Damien P. Devos, Jose L. Gómez-Skarmeta, Jaime J. Carvajal   +9 more
doaj   +1 more source

How TGF‐β and PAX3 regulate suntanning [PDF]

Pigment Cell & Melanoma Research, 2009
The processes by which ultraviolet(UV) radiation induces melanin synthe-sis to induce a suntan is complex,involving signaling between keratino-cytes and melanocytes. Although muchis known about the enzymes involved inmelanin production, there have beengaps in understanding how key tran-scriptional regulators of melanogenesisare regulated.
openaire   +2 more sources

Temporally Regulated Neural Crest Transcription Factors Distinguish Neuroectodermal Tumors of Varying Malignancy and Differentiation

Neoplasia: An International Journal for Oncology Research, 2005
Neuroectodermal tumor cells, like neural crest (NC) cells, are pluripotent, proliferative, and migratory. We tested the hypothesis that genetic programs essential to NC development are activated in neuroectodermal tumors.
Timothy R. Gershon, Orit Oppenheimer, Steven S. Chin, William L. Gerald   +3 more
doaj   +1 more source

Biphenotypic sinonasal sarcoma with PAX3/FOXO1 fusion

Polish Journal of Pathology
Biphenotypic sinonasal sarcoma (BSNS), previously known as low-grade sinonasal sarcoma, is a rare tumour of the sinonasal tract, first described in 2012. It involves both myogenic and neural differentiation and is characterized by PAX3 rearrangement.
Ilkay Tosun, Murat H. Karabulut, Ismail Yilmaz, Ahmet A. Cırık, Onur Sahin   +4 more
openaire   +3 more sources

PAX3 wt Allele [PDF]

, 2020
openaire   +1 more source

A Genomic and Epigenetic Comparative Study of Low-grade Biphenotypic Sinonasal Sarcoma with Metachronous and Synchronous High-grade Rhabdomyosarcomatous Transformation. [PDF]

Head Neck Pathol
Sibira RM, Chen C, Costa FA, Verma A, Singh P, Peterson JE, Hattery T, Racila E, Zhong M, Murugan P, Dermawan JK.   +10 more
europepmc   +1 more source