Results 71 to 80 of about 10,442 (179)
The Journal of Physiology, EarlyView.Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson +6 more
wiley +1 more source
Frontiers in Oncology, 2013 Melanoma is a very aggressive neoplasm with a propensity to undergo progression and invasion early in its evolution. The molecular pathways underpinning invasion in melanoma are now just beginning to be elucidated, but a clear understanding of the ...
Michael R Eccles +6 more
doaj +1 more source
Clinical Genetics, Volume 110, Issue 2, Page 210-226, August 2026.The Burden: Hearing loss (HL) is the most prevalent sensory disorder globally, affecting 1.5 million individuals in Brazil. The Gap: While > 150 genes are linked to HL, the genetic architecture in underrepresented populations like Brazil is poorly defined. The Problem: This lack of data limits diagnostic yield and the application of precision medicine.
Stella Diogo‐Cavassana +7 more
wiley +1 more source
BMC Cancer, 2019 Background Transcription factors forkhead box protein O1 (FOXO1) and paired box 3 (PAX3) have been reported to play important roles in various cancers. However, their role in epithelial ovarian cancer (EOC) has not been elucidated yet.
Gwan Hee Han +5 more
doaj +1 more source
PAX3-FOXO1 Induces Up-Regulation of Noxa Sensitizing Alveolar Rhabdomyosarcoma Cells to Apoptosis
Neoplasia: An International Journal for Oncology Research, 2013 Alveolar rhabdomyosarcoma (ARMS) has a much poorer prognosis than the more common embryonal subtype. Most ARMS tumors characteristically possess a specific genomic translocation between the genes of PAX3/7 and FOXO1 (FKHR), which forms fusion proteins ...
Amy D. Marshall +3 more
doaj +1 more source
ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells
Advanced Science, Volume 13, Issue 37, 3 July 2026.With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao +16 more
wiley +1 more source
Emerging Pathogenic and Prognostic Significance of Paired Box 3 (PAX3) Protein in Adult Gliomas
Translational Oncology, 2019 Gliomas present the most common type of brain tumors in adults, characterized by high morbidity and mortality. In search of potential molecular targets, members of paired box (PAX) family have been found expressed in neural crest cells, regulating their ...
Efthalia Angelopoulou +2 more
doaj +1 more source
Molecular Oncology, 2020 Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and young adults. RMS exists as two major disease subtypes, oncofusion‐negative RMS (FN‐RMS) and oncofusion‐positive RMS (FP‐RMS). FP‐RMS is characterized by recurrent PAX3/7‐FOXO1
Lays M. Sobral +8 more
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Biphenotypic Sinonasal Sarcoma With a Novel PAX3::MAML2 Fusion
Genes, Chromosomes and Cancer, Volume 65, Issue 7, July 2026.ABSTRACT Biphenotypic sinonasal sarcoma (BSNS) is a rare, low‐grade spindle cell sarcoma of the sinonasal tract. It is characterized by dual neural and myogenic differentiation and classically shows fusions involving PAX3. MAML3, a co‐activator in the Notch signaling pathway, is the most common fusion partner of PAX3.
Mayu Uemura +4 more
wiley +1 more source
Muscle type from which satellite cells are derived plays a role in their damage response
Chinese Journal of Physiology, 2020 The aim of this study was to evaluate the response of satellite cells to muscular atrophies which possess different pathological characteristics and which were induced by distinct damages.
Chuang-Yu Lin +3 more
doaj +1 more source