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Calcitonin receptor downregulation and exercise-conditioned blood enable systemic muscle stem cell proliferation. [PDF]
Zhang L +13 more
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Resistance-based exercise restores muscle health in dialysis patients. [PDF]
Srivastava P +13 more
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PAX3 and PAX7 as upstream regulators of myogenesis
Seminars in Cell and Developmental Biology, 2015Like other subclasses within the PAX transcription factor family, PAX3 and PAX7 play important roles in the emergence of a number of different tissues during development. PAX3 regulates neural crest and, together with its orthologue PAX7, is also expressed in parts of the central nervous system.
Margaret Buckingham, Frédéric Relaix
exaly +3 more sources
SUMOylation of Pax7 is essential for neural crest and muscle development [PDF]
Regulatory transcription factors of the Pax family play fundamental roles in the function of multipotent cells during vertebrate development, post-natal regeneration, and cancer. Pax7 and its homologue Pax3 are important players in neural crest and muscle development. Both genes are coexpressed in various tissues and are thought to provide similar, but
Jonathan Marquez +1 more
exaly +3 more sources
Pax7 Is Required for the Specification of Myogenic Satellite Cells [PDF]
The paired box transcription factor Pax7 was isolated by representational difference analysis as a gene specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization revealed that Pax7 was also expressed in satellite cells residing in adult muscle.
Patrick Seale +2 more
exaly +4 more sources
A multiphasic role for Pax7 in tectal development
Experimental Brain Research, 2006The optic tectum differentiates from the mesencephalic alar plate and matures into a characteristically laminated structure. Evidence presented here suggests a role for Pax7 in all stages of development of tectal architecture, from regionalisation to specification of neurons and tectal topography.
Meghan, Thomas +2 more
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Cloning and Characterization of the Human PAX7 Promoter
Biological Chemistry, 2000PAX7, a member of the PAX transcription factor gene family, is normally expressed at high levels during development in the neural tube and in skeletal muscle precursor cells. Interestingly, PAX7 expression was also identified in tumor cells developing from these cell types.
Murmann OV, Niggli F, Schäfer BW
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Structural Analysis of PAX7 Rearrangements in Alveolar Rhabdomyosarcoma
Cancer Genetics and Cytogenetics, 2000In the pediatric cancer alveolar rhabdomyosarcoma, the common 2;13 and less frequent 1;13 translocations fuse PAX3 and PAX7, respectively, with FKHR to produce chimeric genes. To compare structural features of these rearrangements, we cloned and mapped a 64-kb genomic region containing PAX7 exons 5 through 8.
J C, Fitzgerald, A M, Scherr, F G, Barr
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