Results 91 to 100 of about 16,461 (203)

Bisphenol A Induces DNA Damage and Differential Cytotoxicity in Thyroid Cells: High‐Dose Effects Challenge Regulatory Thresholds

Journal of Applied Toxicology, Volume 46, Issue 11, Page 3882-3892, November 2026.
ABSTRACT Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor, has been implicated in carcinogenesis; however, its effects on thyroid cells remain unclear. This study investigated BPA‐induced cytotoxicity and genotoxicity in thyroid cell lines, including normal follicular (Nthy‐ori 3‐1), papillary carcinoma (TPC‐1 and BCPAP) and anaplastic
Izabela Fernanda Dal' Bó, Natássia Elena Bufalo, Valdemar Máximo, Laura Sterian Ward   +3 more
wiley   +1 more source

Thyroid transcription factor 1 rescues PAX8/p300 synergism impaired by a natural PAX8 paired domain mutation with dominant negative activity.

, 2005
Mutations in the paired domain transcription factor PAX8 are a rare cause of congenital hypothyroidism due to thyroid dysgenesis. We identified a novel and unique PAX8 mutation segregating in seven affected members of a three-generations family.
Grasberger, Helmut, Lefrancois, Paule, Abramowicz, Marc, Ringkananont, Usanee, Vassart, Gilbert, Refetoff, Samuel   +5 more
core   +1 more source

Age related neoplasm in experimental animals [PDF]

Iraqi Journal of Veterinary Sciences
The albino rats are commonly recognized as tumor-resistant and appreciable research interest because of the scarcity of reports and article papers on neoplasm tumors.
Hadil B. Al-Sabaawy
doaj   +1 more source

Case Report: Pancreatic Paraganglioma Mimicking a Well‐Differentiated Neuroendocrine Tumor: The Importance of Cytokeratin Immunohistochemistry

Diagnostic Cytopathology, Volume 54, Issue 10, Page E240-E243, October 2026.
ABSTRACT Paragangliomas (PGLs) are uncommon neuroendocrine tumors most commonly found in the head and neck that originate from neural crest cells. Primary pancreatic paraganglioma is exceedingly rare and has largely been described in case reports and small case series. We present the case of a 79‐year‐old woman with an incidental pancreatic head lesion
Tanner Storozuk, Marc Vecchio
wiley   +1 more source

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, Volume 41, Issue 10, Page 975-997, October 2026.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source

Cells expressing PAX8 are the main source of homeostatic regeneration of adult mouse endometrial epithelium and give rise to serous endometrial carcinoma

Disease Models & Mechanisms, 2020
Humans and mice have cyclical regeneration of the endometrial epithelium. It is expected that such regeneration is ensured by tissue stem cells, but their location and hierarchy remain debatable.
Dah-Jiun Fu, A. D. De Micheli, M. Bidarimath, L. H. Ellenson, B. D. Cosgrove, A. Flesken-Nikitin, A. Nikitin   +6 more
semanticscholar   +1 more source

Tissue Factor‐High Ovarian Clear Cell Carcinoma Shows Immune‐Cold Features and Preclinical Activity of Tisotumab Vedotin

Cancer Science, Volume 117, Issue 10, Page 2838-2851, October 2026.
F3/TF‐high ovarian clear cell carcinoma exhibits an immune‐cold phenotype characterized by reduced immune‐cell fractions and attenuated cancer‐cell interferon programs, with frequent B7‐H4 co‐expression. Patient‐derived models show preclinical sensitivity to the TF‐directed antibody–drug conjugate tisotumab vedotin.
Yutaro Mori, Ryo Tamura, Kotaro Takahashi, Kaoru Yamawaki, Tatsuya Ishiguro, Teiichi Motoyama, Koji Okamoto, Kosuke Yoshihara   +7 more
wiley   +1 more source

Unraveling the mysteries of PAX8 in reproductive tract cancers

Cancer Research, 2020
Paired Box 8 (PAX8) is a lineage-specific transcription factor that has essential roles during embryogenesis and tumorigenesis. The importance of PAX8 in the development of the reproductive system is highlighted by abnormalities observed upon the loss or
Daniele Chaves-Moreira, P. Morin, R. Drapkin   +2 more
semanticscholar   +1 more source

PAX8 and MECOM are interaction partners driving Ovarian Carcinogenesis

, 2021
The transcription factor PAX8 is critical for the development of the thyroid and urogenital system. Comprehensive genomic screens furthermore indicate an additional oncogenic role for PAX8 in renal and ovarian carcinogenesis.
Carte, Nathalie, Mermet-Meillon, Fanny Anne-Marie, Vissieres, Alexandra, Kaufmann, Markus, Chau, Suzanne, Roma, Guglielmo, Marques Lopes, Rui, Nieto-Oberhuber, Cristina, Ahrne, Erik, Voshol, Johannes, Fernandez, Cesar, Ferretti, Stephane Raymond, Freuler, Felix, Fischer, Matteo, Cobos-Correa, Amanda, Hinniger, Alexandra, Haenni, Simon, Wahle, Maria, Bleu, Melusine, Barbosa, Ines, Poetsch, Tania, Delmas, Cecile, Gutmann, Sascha, Naumann, Ulrike, Grass, Verena, Stachyra, Therese-Marie, Barys, Louise, Berneiser, Karolin Fiona, Moravec, Ivana, Schuebeler, Dirk, Holzer, Laura, Galli, Giorgio   +31 more
core  

A role for PAX8 in the tumorigenic phenotype of ovarian cancer cells [PDF]

, 2014
Background: PAX8 is a member of the paired box (Pax) multigene family of transcription factors, which are involved in the developmental and tissue-specific control of the expression of several genes in both vertebrates and invertebrates.
Di Palma, Tina, Tina Di Palma, de Cristofaro, Tiziana, Maria Grazia Filippone, Filippone, Maria Grazia, Lucci, Valeria, Valeria Lucci, Mariastella Zannini, Zannini, Mariastella, Tiziana de Cristofaro   +9 more
core   +2 more sources