Results 111 to 120 of about 16,461 (203)

Comparative genomics reveals a functional thyroid-specific element in the far upstream region of the PAX8 gene

BMC Genomics, 2010
Background The molecular mechanisms leading to a fully differentiated thyrocite are still object of intense study even if it is well known that thyroglobulin, thyroperoxidase, NIS and TSHr are the marker genes of thyroid differentiation.
De Felice Mario, Abbondante Serena, de Cristofaro Tiziana, di Gennaro Alessandra, Di Dato Valeria, Nitsch Roberto, Zannini Mariastella, Di Lauro Roberto   +7 more
doaj   +1 more source

Clinical significance of lncRNA PAX8-AS1 and miR-96-5p in non-small cell lung cancer

Journal of Cardiothoracic Surgery
Background This study aims to examine the potential value of lncRNA PAX8-AS1 and miR-96-5p as diagnostic markers in non-small cell lung cancer (NSCLC).
Qiaoling Ying, Hui Xu, Xiaojiao Wu, Hang Fang, Jingjing Shi, Hangcheng Pan   +5 more
doaj   +1 more source

SOX17/PAX8 dual immunohistochemical expression in the diagnosis of Müllerian carcinomas

Diagnostic Pathology
Background Metastatic Müllerian carcinomas, including endometrial and ovarian adenocarcinomas, are challenging to diagnose due to factors like similar malignancies, insufficient clinical history, multiorgan dissemination, and small tumor specimens ...
Manar Moustafa, Marwa Ahmed Mohamed Abdalrahman, Heba Mahmoud Abdelgeleel   +2 more
doaj   +1 more source

Bisphenol A interferes with TTF-1 and PAX8 modulation of dual oxidase 2 human thyroid promoter activity

Academia Molecular Biology and Genomics
Bisphenol A (BPA) is an endocrine disruptor related to the increasing prevalence of goiter and thyroid malignancy. PAX8 and TTF-1 control the expression of the main thyroid differentiation markers, including dual oxidase (Duox) 2, that are ...
Luciana Domênico Queiroz, Paloma Costa Silva, Ricardo Cortez Cardoso Penha, Leandro Miranda-Alves, Andrea Claudia Freitas Ferreira, Carla Eponina de Carvalho Pinto, Luciene de Carvalho Cardoso-Weide   +6 more
doaj   +1 more source

Pax8 protein stability is controlled by sumoylation.

, 2009
The transcription factor Pax8 is involved in the morphogenesis of the thyroid gland and in the maintenance of the differentiated thyroid phenotype. Despite the critical role played by Pax8 during thyroid development and differentiation, very little is ...
PAPPALARDO, ANDREA, D'Andrea B., de Cristofaro T., Mascia A., Zannini M., NITSCH, LUCIO   +5 more
core  

PAX8 expression in normal and tumor thyroid tissues of PTC patients.

, 2016
(A) Mean (SD) PAX8 mRNA levels found in normal thyroid tissuesamples (n = 18) and PTCs (n = 36), assessed by qPCR. (B-D) Representative images of immunohistochemical staining for PAX8 protein levels in (B) normal thyroid tissues; (C) PAX8-positive PTCs ...
Marialuisa Sponziello (2818222), Diego Russo (4706), Sebastiano Filetti (4704), Cosimo Durante (2818228), Carla Di Loreto (20344), Cinzia Puppin (20337), Francesca Rosignolo (2818216), Catia Mio (2818225), Federica Baldan (2818219), Giuseppe Damante (20345)   +9 more
core   +1 more source

Ascitic Fluid in Ovarian Mass with Special Reference to Paired-box Gene 8 Immunoexpression: A Cross-sectional Analysis

International Journal of Advanced Medical and Health Research
Introduction: Mortality in the case of ovarian malignancy is high due to late diagnosis. Early and accurate diagnosis can improve case-specific management.
Prabhat Mahato, Chhanda Das, Rama Saha, Ankita Pranab Mandal, Gourisankar Kamilya   +4 more
doaj   +1 more source

Genetic und epigenetic changes of PAX8 gene in follicular thyroid carcinomas

, 2009
Hintergrund und Fragestellung: PAX8 spielt als Transkriptionsfaktor eine bedeutende Rolle in der Entwicklung der Schilddrüse und der Differenzierung der Schilddrüsenzellen.
Holz, Carmen-Andrea
core   +1 more source

Athyroid Pax8-/- mice cannot be rescued by the inactivation of thyroid hormone receptor α1

, 2005
The Pax8-/- mouse provides an ideal animal model to study the consequences of congenital hypothyroidism, because its only known defect is the absence of thyroid follicular cells.
Visser, T.J., Bauer, K, Visser, Theo, Polsfuss, S. (Silke), Friedrichsen, S., Heuer, H. (Heike), Mittag, J, Polsfuss, S, Visser, T., Friedrichsen, S. (Sönke), Mittag, J., Visser, T. J., Friedrichsen, S, Bauer, K. (Karl), Visser, T.J. (Theo), Polsfuss, S., Mittag, J. (Jens), Heuer, H, Heuer, H., Bauer, K.   +19 more
core   +1 more source

Role of PAX8 and thyroid hormones in metabolic homeostasis [PDF]

, 2018
Trabajo presentado para lograr el título de Doctor por la Universidad Pablo de Olavide, Programa de Doctorado en Biotecnología, Ingeniería y Tecnología Química.--2018-07-09.--Calificación: Sobresaliente Cum LaudeTwo independent studies indicated that ...
López Noriega, Livia del Rocío
core   +1 more source