Results 121 to 130 of about 16,461 (203)

The role of Pax8 in Pancreatic Islet Physiology

, 2015
Motivation: Currently, there are 347 million patients suffering Diabetes Mellitus (DM), raising the obvious need for more effective DM treatments. In this sense, the study of mechanisms that would allow the regeneration and protection of pancreatic ...
Martín Bermudo, Francisco, López Noriega, Livia, Gauthier, Benoit, Martín-Montalvo, Alejandro   +3 more
core   +1 more source

PAX8 directly modulates NRP2 gene expression.

, 2015
(A) FRTL-5 cells were transfected with a siRNA that specifically targets rat PAX8. PAX8 and Neuropilin-2 (NRP2) expression levels were measured on total RNA by qRT-PCR 24h, 48h and 72h after siRNA transfection.
Mariastella Zannini (79171), Tina Di Palma (203998), Valeria Lucci (747688)   +2 more
core   +1 more source

PAX2 and PAX8 Expression in Primary and Metastatic Müllerian Epithelial Tumors

, 2011
PAX2 and PAX8 are transcription factors that are essential in embryonic development of mullerian organs. They may also play a role in tumor development in these organs.
Truong, Luan D., Shen, Steven S., Liles, Nathan, Ayhan Ozcan, Donna Coffey, Steven S. Shen, Coffey, Donna, Nathan Liles, Luan D. Truong, Ozcan, Ayhan   +9 more
core   +1 more source

Modification of the transcription factor Pax8 by SUMO

, 2006
The transcription factor Pax8 is involved in the expression of the thyroid-specific genes that are considered markers of the differentiated phenotype. The regulation of Pax8 activity is likely to play a key role in thyroid differentiation as well as in ...
Pappalardo A, Mascia A, Zannini S, de Cristofaro T   +3 more
core  

Functional Characterization of the <i>PAX8</i> p.Leu264Pro Variant Identified in a Patient with a Müllerian Duct Anomaly. [PDF]

Genes (Basel)
He L, Li L, Li Y, Sun Y, Zheng Z, Chu C, Li L.   +6 more
europepmc   +1 more source

Adipose-Derived Mesenchymal Stem Cells Reduce miR-214-5p to Promote Ovarian Cancer Progression via the β-Catenin Pathway by Targeting PAX8. [PDF]

Stem Cells Int
Sun N, Wang J, Yang H, Liu X, Chu Y.
europepmc   +1 more source

Stage-specific signaling modulation generates low-tumorigenicity thyroid progenitors from human pluripotent stem cells. [PDF]

Front Endocrinol (Lausanne)
Dong L, Peng M, Yao C, Cheng X, Liu H.
europepmc   +1 more source

PAX8 controls proximal tubule epithelial identity and stress response through epigenetic modification of distal regulatory elements. [PDF]

J Biol Chem
Telang AC, Wan M, Orban SK, Stahlecker J, Ference-Salo JT, Delker DA, Shillingford JM, McElliott MC, Laszczyk AM, Vashi RN, Parolia A, Nguyen AL, Snyder RJ, Dressler GR, Watts JA, Beamish JA.   +15 more
europepmc   +1 more source

Poly(ADP-ribose) polymerase-1 binds to Pax8 and inhibits its transcriptional activity.

, 2008
Pax8 is a transcription factor that plays an important role in the regulation of genes that are exclusively expressed in differentiated thyroid cells. In the thyroid cell environment, evidence exists that Pax8 is part of a multiprotein complex in which ...
Zannini M, D'Ambrosio C, Scaloni A, Del Prete D, Di Palma T, de Cristofaro T   +5 more
core  

Genetically Predicted Gene Expression and Circulating Metabolites Associated with Cervical High-Grade Squamous Intraepithelial Lesion: A Mendelian Randomization Study. [PDF]

Int J Womens Health
Cui B, Ding Y, Li F, Hu T, Zhu J, Chang X, Wang Y, Yang J, Cui J.   +8 more
europepmc   +1 more source