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PAX8 Expression in Uterine Adenocarcinomas and Mesonephric Proliferations
International Journal of Gynecological Pathology, 2014PAX8 is a useful immunohistochemical marker for the diagnosis of gynecologic tract malignancies. Several studies have described PAX8 expression in a wide variety of epithelial neoplasms, including ovarian and endometrial carcinomas. The goal of this study was to evaluate PAX8 expression in various types of uterine adenocarcinomas and mesonephric ...
Anna, Yemelyanova +5 more
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Pax8: A marker for carcinoma of Müllerian origin in serous effusions
Diagnostic Cytopathology, 2011AbstractPAX8 is a nuclear transcription factor with limited expression in normal and neoplastic tissues in a cell lineage‐dependent manner. PAX8 has been detected in embryonic Müllerian ducts, human fallopian tubes, and ovarian carcinomas. However, little is known about its expression in other areas of the female genital tract.
Guo-Xia, Tong +7 more
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Expression of PAX8 in Normal and Neoplastic Tissues
Applied Immunohistochemistry & Molecular Morphology, 2011PAX8 is a nephric-lineage transcription factor and is a crucial transcription factor for organogenesis of the thyroid gland, kidney, and Müllerian system. PAX8 is shown to be expressed in a high percentage of kidney and ovarian carcinomas. Limited information is known about the specificity of PAX8 in various neoplastic tumors.
David, Tacha, Ding, Zhou, Liang, Cheng
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Thyroid defects due to Pax8 gene mutations
European Journal of Endocrinology, 1998Congenital hypothyroidism (CH) occurs in 1 in 3000– 4000 newborns. Early diagnosis and therapy are absolutely critical because, when untreated, hypothyroid subjects develop severe and irreversible mental retardation. Thyroid dysgenesis (agenesis, ectopic location or hypoplasia) is the most common cause of CH.
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Congenital Hypothyroidism due to PAX8 Mutations
2015PAX8 is one of the best characterized thyroid-specific transcription factors that play a role in development and physiology of the thyroid gland. PAX8 causes, when mutated, congenital hypothyroidism in both mice and humans, although mode of inheritance is different among the two species (mice, recessive; humans, dominant).
Satoshi Narumi, Tomonobu Hasegawa
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Emerging roles for PAX8 in ovarian cancer and endosalpingeal development
Gynecologic Oncology, 2007Epithelial ovarian carcinomas develop from ovarian surface epithelia that undergo complex differentiation to form distinguishable phenotypes resembling those of the epithelia of the female urogenital regions. While previous studies have implicated regulatory developmental homeobox (HOX) genes in this process, other factors responsible for this ...
Bowen, Nathan J. +6 more
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The role of PAX8 in epithelial ovarian carcinoma
2017Cancer that arises in ovarian tissue is termed ovarian cancer. The majority (>90%) of these are of an epithelial nature, and are thus termed epithelial ovarian carcinomas (EOCs). EOC is the most lethal gynecological malignancy in the United States and the western world, and is the most lethal cancer of the reproductive system.
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PAX8 as a Potential Target for Ovarian Cancer: What We Know so Far
OncoTargets and Therapy, 2022Mariastella Zannini
exaly
PAX8, auseful biomarker for ovarianserous tumors
Human Pathology, 2016Xiang, Lin +4 more
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Modification of the transcription factor Pax8 by SUMO
2006The transcription factor Pax8 is involved in the expression of the thyroid-specific genes that are considered markers of the differentiated phenotype. The regulation of Pax8 activity is likely to play a key role in thyroid differentiation as well as in thyroid malignant transformation.
de Cristofaro T +3 more
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