Results 61 to 70 of about 16,461 (203)

METTL3 regulates thyroid cancer differentiation and chemosensitivity by modulating PAX8

International Journal on Biological Sciences
Background: Thyroid cancer (TC) is a common endocrine cancer with a favourable prognosis. However, poor patient prognosis due to TC dedifferentiation is becoming an urgent challenge. Recently, methyltransferase-like 3 (METTL3)-mediated N6-methyladenosine
Ning Kang, Ze-Wei Zhao, Zhongyu Wang, Junya Ning, Huijuan Wang, Wei Zhang, Xian-Hui Ruan, Ming Gao, Xiangqian Zheng   +8 more
semanticscholar   +1 more source

Association of genomic variants at PAX8 and PBX2 with cervical cancer risk

International Journal of Cancer, 2021
Cervical malignancy is triggered by human papillomavirus infection but the risk for cervical cancer has a hereditary component. From a recent Genome Wide Association Study meta‐analysis, 2q14.1 (PAX8) and 6p21.32 (PBX2) have been proposed as novel ...
D. Ramachandran, Yingying Wang, P. Schürmann, Fabienne Hülse, Q. Mao, M. Jentschke, G. Böhmer, H. Strauß, Christine Hirchenhain, M. Schmidmayr, Florian Müller, I. Runnebaum, A. Hein, M. Koch, M. Ruebner, M. Beckmann, P. Fasching, A. Luyten, Matthias Dürst, P. Hillemanns, T. Dörk   +20 more
semanticscholar   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

IMMUNOHISTOCHEMICAL EXPRESSIONS OF PAX8 IN OVARIAN SURFACE EPITHELIAL TUMORS

The Iraqi Journal of Medical Sciences, 2018
Background: PAX8 is a nuclear transcription factor with limited expression in normal and neoplastic tissues, it has the potential to induce tumorigenesis and is expressed in a tissue during neoplastic transformation.
Samar Al-Shami, Ban Qasim, Ahmed Hassan
doaj   +1 more source

A case of hyalinizing trabecular tumor of the thyroid: diagnostic significance of PAX8-GLIS3 fusion

Thyroid Research
Hyalinizing trabecular tumor (HTT) is an uncommon follicular cell-derived thyroid tumor classified as a low-risk neoplasm by the World Health Organization Classification of Tumors of Endocrine Organs, 5th edition. The PAX8-GLIS3 gene fusion is reportedly
Shuto Hayashi, N. Bandoh, Shogo Baba, Misaki Hayashi, Takashi Goto, M. Takahara, Yasutaka Kato, E. Aimono, Hiroshi Nishihara   +8 more
semanticscholar   +1 more source

PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors

eLife, 2019
PAX8 is a prototype lineage-survival oncogene in epithelial ovarian cancer. However, neither its underlying pro-tumorigenic mechanisms nor potential therapeutic implications have been adequately elucidated. Here, we identified an ovarian lineage-specific
Kaixuan Shi, Xia Yin, Mei-Chun Cai, Ying Yan, Chenqiang Jia, Pengfei Ma, Shengzhe Zhang, Zhenfeng Zhang, Zhenyu Gu, Meiying Zhang, Wen Di, Guanglei Zhuang   +11 more
doaj   +1 more source

ViTAMIn‐O: Democratizing Computer Vision‐Based Machine Learning for Stem Cell Research

Advanced Intelligent Systems, EarlyView.
This study introduces a fully open generalist computer vision model for predicting the differentiation outcomes of stem cell‐based model systems, together with its code‐free deployment platform, ColabViTAMIn‐O. It is benchmarked against various architectures, datasets, and training protocols.
Ferhat Hamurcu, Markus Breunig, Arpad Varga, Bianka Bosch, Jessica Lindenmayer, Anjan T. Kanakappady, Kevin Achberger, Natalia Pashkovskaia, Alexander Kleger, Stefan Liebau, Stefanie Klingenstein, Moritz Klingenstein   +11 more
wiley   +1 more source

hsa_circ_0139402 Promotes Bladder Cancer Progression by Regulating hsa-miR-326/PAX8 Signaling

Disease Markers, 2022
Background Bladder cancer (BC) is a malignant and common malignant tumors. However, the prognosis of most patients with bladder cancer is still poor, and it is particularly important to identify early tumor diagnostic and treatment targets. Materials and
Bo Wei, Zunxian Wang, Qixin Lian, Bao-Jin Chi, Shu-Xia Ma   +4 more
semanticscholar   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

MiR-326 inhibits trophoblast growth, migration, and invasion by targeting PAX8 via Hippo pathway

Reproductive Biology and Endocrinology, 2022
Preeclampsia (PE), a pregnancy disorder that affects 5–7% of pregnant women, is among the primary causes for maternal and perinatal mortality. PE is believed to be associated with insufficient invasion of villous and extravillous trophoblasts (EVTs ...
J. Zang, Min Yan, Yan Zhang, Wei Peng, Jian-Xin Zuo, Huan-Sheng Zhou, Guoqiang Gao, Min Li, Yijing Chu, Yuanhua Ye   +9 more
semanticscholar   +1 more source