Results 51 to 60 of about 16,461 (203)

The Diagnostic Utility of PAX8 for Neuroendocrine Tumors: An Immunohistochemical Reappraisal

open access: yes, 2017
PAX8 is a transcription factor crucial for the development of the kidneys, thyroid glands, and Mullerian system. It is commonly expressed by epithelial tumors from these organs.
Liau, Jau-Yu;Tsai, Jia-Huei;Jeng, Yung-Ming;Kuo, Kuan-Ting;Huang, Hsin-Yi;Liang, Cher-Wei;Yang, Ching-Yao   +1 more
core   +1 more source

The expression of immunohistochemical biomarkers PAX8 and CD117 in platinum resistant ovarian cancer at Saiful Anwar General Hospital, Malang, Indonesia

open access: yesMajalah Obstetri dan Ginekologi
HIGHLIGHTS • Ovarian cancer is a gynecological disease commonly encountered by women, and resistance to platinum therapy is a significant challenge in its management • PAX8 and CD117 have shown potential as predictors of resistance in ovarian cancer ...
Robby Rinaldi Widodo   +4 more
doaj   +1 more source

Excess heme orchestrates progesterone resistance in uterine endometrial cancer through macrophage polarization and the IL-33/PAX8/PGR axis.

open access: yesBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Progesterone is an important drug for hormone therapy in uterine endometrial cancer (UEC). However, the therapeutic efficacy of progestogen is often limited by resistance, and the underlying mechanism remains unknown.
Jia-Jing Lu   +7 more
semanticscholar   +1 more source

A specific Translocation of Chromosome 3 Generating Pax8-PPARg Fusion mRNA is Rare in Japanese Patients with Follicular Carcinoma

open access: yes, 2002
2002-12Thyroid follicular neoplasm is commonly encountered in clinical medicine. However, it is difficult to pathologically differentiate benign from malignant tumors.
KAMBE, Fukushi   +5 more
core   +1 more source

The zebrafish model to identify new genes involved in thyroid development [PDF]

open access: yes, 2010
Thyroid organogenesis is a very complex developmental process that leads to the formation of an organ able to produce specific hormones through specification, migration, structural organization and functional differentiation of thyroid precursor cells ...
Porreca, Immacolata
core   +1 more source

A Cutaneous Ciliated Cyst Mımicking a Pilonidal Cyst [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2018
Cutaneous Ciliated Cyst (CCC) is a benign tumor encountered especially in the upper extremities and the perineal area in young women after puberty. CCC is located in the subcutaneous tissue in deep dermis, and histologically, it is a single, unilocular ...
Seda Gun, Duygu Kuru, Levent Yıldız
doaj   +1 more source

DNA methylation at a nutritionally sensitive region of the PAX8 gene is associated with thyroid volume and function in Gambian children

open access: yesScience Advances, 2021
Child PAX8 methylation is associated with thyroid volume and function and influenced by maternal periconceptional nutrition.
T. Candler   +14 more
semanticscholar   +1 more source

Gene expression profiles during thyroid embryonic development [PDF]

open access: yes, 2009
Congenital Hypothyroidism (CH) is commonly due to structural defects of thyroid gland, collectively known as thyroid dysgenesis. Defects in growth and/or differentiation of the thyroid primordium can result in an absent (athyreosis) or hypoplastic ...
Parrillo, Luca
core   +1 more source

9.IMMUNOHISTOCHEMICAL EXPRESSIONS OF PAX8 IN OVARIAN SURFACE EPITHELIAL TUMORS

open access: yesThe Iraqi Journal of Medical Sciences, 2018
Background: PAX8 is a nuclear transcription factor with limited expression in normal and neoplastic tissues, it has the potential to induce tumorigenesis and is expressed in a tissue during neoplastic transformation.
Samar A. Al-Shami   +2 more
doaj   +6 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

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