Results 31 to 40 of about 16,461 (203)

Paired box 8 suppresses tumor angiogenesis and metastasis in gastric cancer through repression of FOXM1 via induction of microRNA-612

Journal of Experimental & Clinical Cancer Research, 2018
Background Paired box 8 (PAX8) has been documented to be downregulated in gastric cancer. However, its biological function in this malignancy is poorly understood.
Liyan Wang, Xiaotong Bo, Qinghua Zheng, Wenhong Ge, Yanhua Liu, Bin Li   +5 more
doaj   +1 more source

A combination of immunohistochemical markers, MUC1, MUC5AC, PAX8 and growth pattern for characterization of mucinous neoplasm of the ovary

International Journal of Gynecological Cancer, 2022
Objective Because mucinous carcinomas are rare tumors that affect several organ sites and are known to originate from different tissues, leading to frequent misdiagnoses, the objective was to characterize the differences between primary mucinous tumors ...
A. Chelariu-Raicu, E. Holley, D. Mayr, Frederick Klauschen, F. Wehweck, M. Rottmann, M. Kessler, T. Kaltofen, B. Czogalla, F. Trillsch, S. Mahner, E. Schmoeckel   +11 more
semanticscholar   +1 more source

Genetic testing of PAX8 mutations associated with thyroid dysgenesis in Chinese congenital hypothyroidism patients

Endokrynologia Polska, 2020
INTRODUCTION: Thyroid dysgenesis (TD) is the main cause of congenital hypothyroidism (CH), affecting nearly 1 in 2000–3000 newborns worldwide, as the most common neonatal endocrine disorder.
Miaomiao Li, Fang Wang, Xiuli Wang, Yucui Zang, Wenmiao Liu, Fengqi Wang, Lu Zhang, Qian Tang, Shiguo Liu, Dehua Zhao   +9 more
doaj   +1 more source

The Significance of PAX8-PPARγ Expression in Thyroid Cancer and the Application of a PAX8-PPARγ-Targeted Ultrasound Contrast Agent in the Early Diagnosis of Thyroid Cancer

Contrast Media & Molecular Imaging, 2022
Objective To investigate the significance of PAX8-PPARγ expression in thyroid cancer and the application of a PAX8-PPARγ-targeted ultrasound contrast agent in the early diagnosis of thyroid cancer.
Tian-Bing Fan, Wenwen Zhu, M. Kong, Xiaochan Yang, Cheng Wang, Min Wang, Zhaoyin Wang   +6 more
semanticscholar   +1 more source

PAX8 (paired box 8) [PDF]

, 2010
Pax8 is a transcription facto expressed in embryonal human tissues, in particular in the developing thyroid gland, kidney, Müllerian structures, and nervous system (e.g. otic placode), and in the human placenta.
MORANDI, LUCA, TALLINI, GIOVANNI, DE BIASE, DARIO   +2 more
core   +2 more sources

Impact of fixations on anti-genetic determinants of CD4, CD68, and Pax8 immunohistochemistry: A comparative study of NBF, Zink formalin, and Bouin's fluid [PDF]

Iraqi Journal of Veterinary Sciences
Fixation inhibits autolysis and is an essential step in disease. Our work examined how neutral buffer NBF (NBF), zinc formalin (ZF), and Bouin's fluid (BF) affected tissue specific CD4, CD68, and Pax8 anti-genetic determinants.
Amani A. Alayash, Firas M. Abed
doaj   +1 more source

Identification of novel Pax8 targets in FRTL-5 thyroid cells by gene silencing and expression microarray analysis. [PDF]

PLoS ONE, 2011
The differentiation program of thyroid follicular cells (TFCs), by far the most abundant cell population of the thyroid gland, relies on the interplay between sequence-specific transcription factors and transcriptional coregulators with the basal ...
Tina Di Palma, Anna Conti, Tiziana de Cristofaro, Serena Scala, Lucio Nitsch, Mariastella Zannini   +5 more
doaj   +1 more source

Multi-genomic analysis of 260 adrenocortical cancer patient tumors identifies novel network BIRC5-hsa-miR-335-5p-PAX8-AS1 strongly associated with poor survival.

Surgery, 2022
BACKGROUND Adrenocortical carcinoma is a rare endocrine cancer with poor overall survival. Linking survival outcomes to a common target across multiple genomic datasets incorporating microRNA-long non-coding RNA dysregulation have not been well described.
C. Subramanian, Reid McCallister, M.S. Cohen   +2 more
semanticscholar   +1 more source

Exon capture and bulk segregant analysis: rapid discovery of causative mutations using high-throughput sequencing

BMC Genomics, 2012
Background Exome sequencing has transformed human genetic analysis and may do the same for other vertebrate model systems. However, a major challenge is sifting through the large number of sequence variants to identify the causative mutation for a given ...
del Viso Florencia, Bhattacharya Dipankan, Kong Yong, Gilchrist Michael J, Khokha Mustafa K   +4 more
doaj   +1 more source

Carcinosarcoma arising from high-grade serous carcinoma of the ovary without estrogen receptor, WT-1, and PAX8 immunoreactivity.

Taiwanese Journal of Obstetrics & Gynecology, 2022
OBJECTIVE We encountered a case of high-grade serous carcinoma (HGSC) of the ovary which recurred as carcinosarcoma of the sigmoid colon. Tumor cells of both the primary carcinoma and the secondary carcinosarcoma were negative for estrogen receptor (ER),
N. Harada, I. Nobuhara, N. Haruta, Yumi Higashiura, H. Fujii, Kaho Yamao, K. Shimada   +6 more
semanticscholar   +1 more source