Results 21 to 30 of about 10,828 (178)
Journal of Experimental & Clinical Cancer Research, 2018 Background Paired box 8 (PAX8) has been documented to be downregulated in gastric cancer. However, its biological function in this malignancy is poorly understood.
Liyan Wang +5 more
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Identification of novel Pax8 targets in FRTL-5 thyroid cells by gene silencing and expression microarray analysis. [PDF]
PLoS ONE, 2011 The differentiation program of thyroid follicular cells (TFCs), by far the most abundant cell population of the thyroid gland, relies on the interplay between sequence-specific transcription factors and transcriptional coregulators with the basal ...
Tina Di Palma +5 more
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Significance analysis of PAX8 expression in endometrial carcinoma
Medicine, 2022 To analyze the expression and prognostic value of paired-box 8 (PAX8) expression in uterine corpus endometrial carcinoma (UCEC) by bioinformatics. The expression of PAX8 gene in UCEC was analyzed by R language and immunohistochemistry. The correlation between PAX8 expression and clinicopathological features was analyzed by R language.
Shan Hu, Hua Gan, Fengmei Yang
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Cancer Cell International, 2019 Background Ovarian cancer is the third most common cause of death among gynecologic malignancies worldwide. Understanding the biology and molecular pathogenesis of ovarian epithelial tumors is key to developing improved prognostic indicators and ...
Amata Amy Soriano +8 more
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Impact of fixations on anti-genetic determinants of CD4, CD68, and Pax8 immunohistochemistry: A comparative study of NBF, Zink formalin, and Bouin's fluid [PDF]
Iraqi Journal of Veterinary SciencesFixation inhibits autolysis and is an essential step in disease. Our work examined how neutral buffer NBF (NBF), zinc formalin (ZF), and Bouin's fluid (BF) affected tissue specific CD4, CD68, and Pax8 anti-genetic determinants.
Amani A. Alayash, Firas M. Abed
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50 Therapeutic opportunities in the master transcription factor circuitries of clear cell carcinomas
Gynecologic Oncology Reports, 2023 Objectives: Transcription factors are emerging as targets for novel therapeutics for the treatment of malignancies. We sought to evaluate functions of PAX8 and HNF1B in both clear cell ovarian cancer (CCOC) and clear cell renal cell carcinoma (ccRCC) to ...
Nolan J. Kinne +7 more
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PAX8 expression in human bladder cancer
Oncology Reports, 2006 PAX8 is a transcription factor with a role in ontogenesis of the urinary tract. The aim of the present investigation was to investigate PAX8 expression in normal bladder and in non-invasive urothelial tumours. Nine cases of normal urothelial mucosa, 2 cases of papillary urothelial neoplasia of low malignant potential, 12 cases of low grade non-invasive
PELLIZZARI, Lucia +7 more
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BMC Genomics, 2012 Background Exome sequencing has transformed human genetic analysis and may do the same for other vertebrate model systems. However, a major challenge is sifting through the large number of sequence variants to identify the causative mutation for a given ...
del Viso Florencia +4 more
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Diagnostic Pathology, 2023 Background Histomorphological differentiation between pancreatic serous cystadenoma (SCA) and clear cell renal cell carcinoma (RCC) can be challenging. We aimed to study Paired box 8 protein (Pax8) expression profile in cytologic and surgical specimens ...
Zhikai Chi +3 more
doaj +1 more source
PAX8 expression in ovarian surface epithelial cells [PDF]
Human Pathology, 2015 High-grade serous ovarian carcinoma (HGSOC) is usually diagnosed at a late stage and is associated with poor prognosis. Understanding early stage disease biology is essential in developing clinical biomarkers to detect HGSOC earlier. While recent studies indicate that HGSOCs arise from fallopian tube secretory epithelial cells, a considerable body of ...
Emily, Adler +3 more
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