Results 21 to 30 of about 16,461 (203)

Fibromyxoid Nephrogenic Adenoma Mimicking Renal Cell Carcinoma: A Diagnostic Pitfall in Fine-Needle Aspiration Cytology. [PDF]

Diagn Cytopathol
ABSTRACT Nephrogenic adenoma (NA) is a benign lesion of the genitourinary tract that may mimic malignancy both clinically and histologically. The fibromyxoid variant (FMNA), characterized by spindled cells in myxoid stroma, presents additional diagnostic challenges due to its rarity and overlapping features with renal cell carcinoma (RCC).
Gedallovich J, Adeniyi A, Sangoi AR, Qian X, Ernst K.   +4 more
europepmc   +2 more sources

Novel Missense Variants in PAX8 and NKX2-1 Cause Congenital Hypothyroidism

International Journal of Molecular Sciences, 2023
Primary congenital hypothyroidism (CH) is a common neonatal endocrine disorder characterized by elevated concentrations of thyroid stimulating hormone (TSH) and low concentrations of free thyroxine (FT4).
Menglin Li, Zhuo Li, Miaomiao Chen, Zhi-Qing Hu, Miao-Jin Zhou, Lingqian Wu, Chunhua Zhang, D. Liang   +7 more
semanticscholar   +1 more source

PAX8 and MECOM are interaction partners driving ovarian cancer

Nature Communications, 2021
The transcription factor PAX8 is critical for the development of the thyroid and urogenital system. Comprehensive genomic screens furthermore indicate an additional oncogenic role for PAX8 in renal and ovarian cancers.
Melusine Bleu, F. Mermet-Meillon, Verena Apfel, Louise Barys, Laura Holzer, Marianne Bachmann Salvy, R. Lopes, Inês Amorim Monteiro Barbosa, C. Delmas, A. Hinniger, Suzanne Chau, M. Kaufmann, Simon Haenni, Karolin Berneiser, M. Wahle, Ivana Moravec, Alexandra Vissières, Tania Poetsch, Erik Ahrné, N. Carte, J. Voshol, Elisabeth Bechter, Jacques Hamon, M. Meyerhofer, D. Erdmann, Matteo Fischer, T. Stachyra, F. Freuler, S. Gutmann, C. Fernández, T. Schmelzle, U. Naumann, G. Roma, K. Lawrenson, C. Nieto-Oberhuber, Amanda Cobos-Correa, S. Ferretti, D. Schübeler, G. Galli   +38 more
semanticscholar   +1 more source

Paired box 8 facilitates the c-MYC related cell cycle progress in TP53-mutation uterine corpus endometrial carcinoma through interaction with DDX5

Cell Death Discovery, 2022
As a molecular marker of the female reproductive system, Paired Box 8 is widely used in pathological diagnosis of gynecological tumors, but it is not clear whether its expression level is related to the development of uterine corpus endometrial carcinoma
Ping Qiu, Youkun Jie, Cheng Ma, Huifeng Chen, Yunna Qin, Kaijia Tu, Liqun Wang, Ziyu Zhang   +7 more
doaj   +1 more source

The PAX8 cistrome in epithelial ovarian cancer [PDF]

, 2017
PAX8 is a lineage-restricted transcription factor that is expressed in epithelial ovarian cancer (EOC) precursor tissues, and in the major EOC histotypes.
Gayther, Simon A., Sowter, H, Sowter, Heidi M., Dennis J. Hazelett, Lee, J, Hazelett, Dennis J., Lawrenson, K, Rodriguez-Malave, N, Mhawech-Fauceglia, P, Rosario I. Corona, Corona, R, Adler, Emily K., Janet M. Lee, Kate Lawrenson, Simon A. Gayther, Paulette Mhawech-Fauceglia, Hazelett, D, Mhawech-Fauceglia, Paulette, Emily K. Adler, Lee, Janet M., Norma Rodriguez-Malave, Heidi Sowter, Adler, E, Gayther, S, Lawrenson, Kate, Rodriguez-Malave, Norma, Corona, Rosario I.   +26 more
core   +1 more source

PAX8 in the Junction between Development and Tumorigenesis

International Journal of Molecular Sciences, 2022
Normal processes of embryonic development and abnormal transformation to cancer have many parallels, and in fact many aberrant cancer cell capabilities are embryonic traits restored in a distorted, unorganized way.
R. Kakun, Zohar Melamed, Ruth Perets
semanticscholar   +1 more source

Curcumol Targeting PAX8 Inhibits Ovarian Cancer Cell Migration and Invasion and Increases Chemotherapy Sensitivity of Niraparib

Journal of Oncology, 2022
Objective To investigate the effects of Curcumol on invasion, migration and epithelial-mesenchymal transformation of IGROV-1 and OVCAR-3 cells in ovarian cancer and its potential mechanism.
Caihong Liu
semanticscholar   +1 more source

Evaluation of PAX8 expression promotes the proliferation of stomach Cancer cells

BMC Molecular and Cell Biology, 2019
Background PAX8 was not only a mitotic factor, but identified as a transcription factor involved in the prognosis of human tumor patients. Elucidating the function of PAX8 on the pathology of stomach cancer was meaningful.
Liang-Yu Bie, Ning Li, Wen-Ying Deng, Xiao-Yu Lu, Ping Guo, Su-Xia Luo   +5 more
doaj   +1 more source

Adipose‐derived mesenchymal stem cells induced PAX8 promotes ovarian cancer cell growth by stabilizing TAZ protein

Journal of Cellular and Molecular Medicine, 2021
Our previous studies have shown that the Adipose‐derived mesenchymal stem cells (ADSCs) can regulate metastasis and development of ovarian cancer. However, its specific mechanism has yet to be fully revealed.
Yijing Chu, Cheng-Zhan Zhu, Qian-Qian Wang, Meixin Liu, W. Wan, Jun Zhou, Rendong Han, Jing Yang, Wenqiang Luo, Chong Liu, Huan-Sheng Zhou, Min Li, Feng-Sheng Yu, Yuanhua Ye   +13 more
semanticscholar   +1 more source

Significance analysis of PAX8 expression in endometrial carcinoma

Medicine, 2022
To analyze the expression and prognostic value of paired-box 8 (PAX8) expression in uterine corpus endometrial carcinoma (UCEC) by bioinformatics. The expression of PAX8 gene in UCEC was analyzed by R language and immunohistochemistry.
Sha Hu, Huan-Huan Gan, Feng-Mei Yang
semanticscholar   +1 more source