Results 41 to 50 of about 16,461 (203)

50 Therapeutic opportunities in the master transcription factor circuitries of clear cell carcinomas

Gynecologic Oncology Reports, 2023
Objectives: Transcription factors are emerging as targets for novel therapeutics for the treatment of malignancies. We sought to evaluate functions of PAX8 and HNF1B in both clear cell ovarian cancer (CCOC) and clear cell renal cell carcinoma (ccRCC) to ...
Nolan J. Kinne, Soledad Ochoa, Marla Scott, Forough Abbasi, Pak Hin Yu, Marcela Haro, BJ Rimel, Kate Lawrenson   +7 more
doaj   +1 more source

Two Cases of Pelvic Biphasic Synovial Sarcoma With Expression of PAX8 and ER: A Diagnostic Pitfall.

International Journal of Gynecological Pathology, 2022
Synovial sarcoma (SS) is a high-grade malignant neoplasm frequently arising in the deep soft tissue of the lower and upper extremities of young adult. Primary SS in pelvis is extremely rare with scattered case reports.
Lan Zheng, X. Wang, Shao-Xiong Chen, A. Moosvi, David Q Wan, Songling Zhang   +5 more
semanticscholar   +1 more source

Role of Pax8 transcriptional factor in the differentiated thyroid [PDF]

, 2010
In Pax8-/- mice the thyroid anlage disappears around E11.5. At birth the gland appears as a rudimentary structure composed only of C cells while thyroid follicular cells are undetectable. Thus, this model does not allow the study of Pax8 function in the
Marotta, Pina
core   +1 more source

PAX8 expression in high-grade serous ovarian cancer positively regulates attachment to ECM via Integrin β3

Cancer Cell International, 2019
Background Ovarian cancer is the third most common cause of death among gynecologic malignancies worldwide. Understanding the biology and molecular pathogenesis of ovarian epithelial tumors is key to developing improved prognostic indicators and ...
Amata Amy Soriano, Tiziana de Cristofaro, Tina Di Palma, Serena Dotolo, Priyanka Gokulnath, Antonella Izzo, Gaetano Calì, Angelo Facchiano, Mariastella Zannini   +8 more
doaj   +1 more source

Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer

Nature Communications, 2020
The functional consequences of somatic non-coding mutations in ovarian cancer (OC) are unknown. To identify regulatory elements (RE) and genes perturbed by acquired non-coding variants, here we establish epigenomic and transcriptomic landscapes of ...
R. Corona, Ji-Heui Seo, Xianzhi Lin, Dennis J. Hazelett, J. Reddy, Marcos A. S. Fonseca, Forough Abassi, Yvonne G. Lin, P. Mhawech-fauceglia, Sohrab P. Shah, D. Huntsman, Alexander Gusev, B. Karlan, B. Berman, M. Freedman, S. Gayther, K. Lawrenson   +16 more
semanticscholar   +1 more source

A patient with congenital hypothyroidism due to a PAX8 frameshift variant accompanying a urogenital malformation

Clinical Pediatric Endocrinology, 2022
. PAX8 is a transcription factor that is expressed in the thyroid gland and kidneys. Monoallelic loss-of-function PAX8 variants cause congenital hypothyroidism (CH), and urogenital malformations are infrequent complications seen in less than 10% of PAX8 ...
Kanako Tanase-Nakao, K. Muroya, M. Adachi, K. Abe, T. Hasegawa, S. Narumi   +5 more
semanticscholar   +1 more source

Pax8 as a useful adjunct marker to differentiate pancreatic serous cystadenoma from clear cell renal cell carcinoma in both cytologic and surgical specimens

Diagnostic Pathology, 2023
Background Histomorphological differentiation between pancreatic serous cystadenoma (SCA) and clear cell renal cell carcinoma (RCC) can be challenging. We aimed to study Paired box 8 protein (Pax8) expression profile in cytologic and surgical specimens ...
Zhikai Chi, Jing Xu, Dipti M. Karamchandani, Lan Peng   +3 more
doaj   +1 more source

Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8‐AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma

Advancement of science
The standard regimen of gemcitabine combined with cisplatin offers limited clinical benefits in the treatment of advanced intrahepatic cholangiocarcinoma (ICC) due to intrinsic or acquired resistance.
Zhi-Wen Chen, Jijun Shan, Mo Chen, Zong Wu, Yi-Ming Zhao, Hong Zhu, Xin Jin, Yi-xiu Wang, Yibin Wu, Zhen Xiang, Zhiwe Ding, Zhenhai Lin, Long Wang, Lu Wang   +13 more
semanticscholar   +1 more source

LncRNA-PAX8-AS1 Silencing Decreases Cell Viability, Enhances Apoptosis, and Suppresses Doxorubicin Resistance in Myeloid Leukemia via the miR-378g/ERBB2 Axis

Evidence-Based Complementary and Alternative Medicine, 2022
Objective Considering the role of lncRNAs reported as regulators in acute myeloid leukemia (AML) progression, the current research aims to investigate the role of PAX8-AS1 in chemo-resistant AML.
Xiaolu Song, Yi-Rui Chen, Ye Peng, Xiaogang Wang, Su-Jie Zheng, Fangfang Shi, Jian-Ping Lan   +6 more
semanticscholar   +1 more source

Paired-Box Gene 8 (PAX8) and Its Association With Epithelial Carcinomas

Cureus, 2021
Cancer is the second most common culprit of mortality in the United States and epithelial carcinomas are considered as one of the most predominant types of cancer.
Khalid Khizer, Jaskamal Padda, Anwar Khedr, Fahriba Tasnim, Ola A. Al-Ewaidat, Vinay Patel, Dina Ismail, Victor Yosef Melt Campos, Gutteridge Jean-Charles   +8 more
semanticscholar   +1 more source