Results 11 to 20 of about 10,828 (178)
Expression of PAX8 Target Genes in Papillary Thyroid Carcinoma. [PDF]
PLoS ONE, 2016 PAX8 is a thyroid-specific transcription factor whose expression is dysregulated in thyroid cancer. A recent study using a conditional knock-out mouse model identified 58 putative PAX8 target genes. In the present study, we evaluated the expression of 11
Francesca Rosignolo +9 more
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Prognostic value of PAX8 in small cell lung cancer
Heliyon, 2023 Objectives: Small cell lung cancer (SCLC) shows poor prognosis since it metastasizes widely at early stage. Paired box gene (PAX) 8 is a transcriptional factor of PAX family, of which the expression in lung cancer is a controversial issue, and its ...
Fengyun Tao +8 more
doaj +3 more sources
The PAX8 cistrome in epithelial ovarian cancer [PDF]
Oncotarget, 2017 PAX8 is a lineage-restricted transcription factor that is expressed in epithelial ovarian cancer (EOC) precursor tissues, and in the major EOC histotypes. Frequent overexpression of PAX8 in primary EOCs suggests this factor functions as an oncogene during tumorigenesis, however, the biological role of PAX8 in EOC development is poorly understood.
Adler, E +8 more
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Nephric lineage specification by Pax2 and Pax8 [PDF]
Genes & Development, 2002 The mammalian kidney develops in three successive steps from the initial pronephros via the mesonephros to the adult metanephros. Although the nephric lineage is specified during pronephros induction, no single regulator, including the transcription factor Pax2 or Pax8, has yet been identified to control this initial phase of ...
Bouchard, Maxime +4 more
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Pax8 protein stability is controlled by sumoylation [PDF]
Journal of Molecular Endocrinology, 2008 The transcription factor Pax8 is involved in the morphogenesis of the thyroid gland and in the maintenance of the differentiated thyroid phenotype. Despite the critical role played by Pax8 during thyroid development and differentiation, very little is known of its post-translational modifications and how these modifications may regulate its activity ...
de Cristofaro T. +5 more
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Evaluation of PAX8 expression promotes the proliferation of stomach Cancer cells
BMC Molecular and Cell Biology, 2019 Background PAX8 was not only a mitotic factor, but identified as a transcription factor involved in the prognosis of human tumor patients. Elucidating the function of PAX8 on the pathology of stomach cancer was meaningful.
Liang-Yu Bie +5 more
doaj +1 more source
SOX13 dependent PAX8 expression promotes the proliferation of gastric carcinoma cells
Artificial Cells, Nanomedicine, and Biotechnology, 2019 PAX8 is identified as a regulator in the pathogenesis of human tumours and an indicator of the prognosis for patients. However, the role of PAX8 on proliferation in gastric cancer have not been studied.
Liang-Yu Bie +5 more
doaj +1 more source
Unraveling the Mysteries of PAX8 in Reproductive Tract Cancers
Cancer Research, 2021 Abstract Paired Box 8 (PAX8) is a lineage-specific transcription factor that has essential roles during embryogenesis and tumorigenesis. The importance of PAX8 in the development of the reproductive system is highlighted by abnormalities observed upon the loss or mutation of this PAX family member.
Daniele Chaves-Moreira +2 more
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Endokrynologia Polska, 2020 INTRODUCTION: Thyroid dysgenesis (TD) is the main cause of congenital hypothyroidism (CH), affecting nearly 1 in 2000–3000 newborns worldwide, as the most common neonatal endocrine disorder.
Miaomiao Li +9 more
doaj +1 more source
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on PAX8 (paired box 8), with data on DNA, on the protein encoded, and where the gene is implicated.
DE BIASE, DARIO +2 more
openaire +3 more sources