Results 11 to 20 of about 16,461 (203)

Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms along with their expression with clinical and subclinical hypothyroidism

Scientific Reports, 2023
The genetic and epigenetic architecture of clinical and subclinical hypothyroidism remains unclear. We investigated the impact of long noncoding RNA (LncRNA)-PAX8-AS1 and LAIR-2 genetic variants on the susceptibility to clinical and subclinical ...
Omar M. Elsayed, Samy A. Abdelazim, Hebatallah A. Darwish, Olfat G. Shaker, Mahmoud A. Senousy   +4 more
doaj   +2 more sources

PAX8 Distinguishes Diffuse Large B-Cell Lymphoma Mimicking Sarcoma [PDF]

Case Reports in Pathology, 2017
PAX8 is important for embryogenesis of the thyroid, Müllerian system, and upper urinary/renal tract, and expression of PAX8 has been described in carcinomas from each of these sites.
Michelle S. Hirsch, Alessandra F. Nascimento   +1 more
doaj   +2 more sources

Genome-wide analysis of Pax8 binding provides new insights into thyroid functions [PDF]

BMC Genomics, 2012
Background The transcription factor Pax8 is essential for the differentiation of thyroid cells. However, there are few data on genes transcriptionally regulated by Pax8 other than thyroid-related genes.
Ruiz-Llorente Sergio, de Pau Enrique Carrillo, Sastre-Perona Ana, Montero-Conde Cristina, Gómez-López Gonzalo, Fagin James A, Valencia Alfonso, Pisano David G, Santisteban Pilar   +8 more
doaj   +2 more sources

Clinicopathological Relevance of PAX8 Expression Patterns in Acute Kidney Injury and Chronic Kidney Diseases

Diagnostics, 2022
Transcription factor PAX8, expressed during embryonic kidney development, has been previously detected in various kidney tumors. In order to investigate expression of PAX8 transcription factor in acute kidney injury (AKI) and chronic kidney diseases (CKD)
Maja Zivotic, Dusko Dundjerovic, Radomir Naumovic, Sanjin Kovacevic, Milan Ivanov, Danijela Karanovic, Gorana Nikolic, Jasmina Markovic-Lipkovski, Sanja Radojevic Skodric, Jelena Nesovic Ostojic   +9 more
doaj   +2 more sources

Overexpression of PAX8-AS1 Inhibits Malignant Phenotypes of Papillary Thyroid Carcinoma Cells via miR-96-5p/PKN2 Axis

International Journal of Endocrinology, 2021
Background. Thyroid carcinoma (THCA) is the most frequent endocrine malignancy. Papillary thyroid carcinoma (PTC) is the major subtype of THCA, accounting for over 80% of all THCA cases.
Ping Zhou, Tongdao Xu, Hao Hu, Fei Hua
doaj   +2 more sources

Expression of PAX8 Target Genes in Papillary Thyroid Carcinoma. [PDF]

PLoS ONE, 2016
PAX8 is a thyroid-specific transcription factor whose expression is dysregulated in thyroid cancer. A recent study using a conditional knock-out mouse model identified 58 putative PAX8 target genes. In the present study, we evaluated the expression of 11
Francesca Rosignolo, Marialuisa Sponziello, Cosimo Durante, Cinzia Puppin, Catia Mio, Federica Baldan, Carla Di Loreto, Diego Russo, Sebastiano Filetti, Giuseppe Damante   +9 more
doaj   +3 more sources

High expression of PAX8-AS1 correlates with poor prognosis and response to fluorouracil-based chemotherapy in stage II colon cancer

Translational Oncology
Decisions regarding adjuvant therapy in patients with stage II colon cancer remains controversial and challenging. We aimed to determine novel biomarkers that help to predict relapse free survival (RFS) and identify a subset of patients with stage II ...
Hongsheng Fang, Lingyu Han, Yun Xu, Ruiqi Gu, Guoxiang Cai, Zuguang Xia, Weixing Dai, Renjie Wang   +7 more
doaj   +2 more sources

Metastasis of Invasive Ductal Carcinoma of the Breast to the Uterine Cervix 30 Years Post-Mastectomy: A Case Report. [PDF]

J Obstet Gynaecol Res
ABSTRACT Metastasis of invasive ductal carcinoma of the breast to the uterine cervix is rare, with only one report of a case occurring more than 20 years after the primary surgery. A 69‐year‐old woman presented with abnormal uterine cervical cytology (atypical glandular cells without tumor diathesis) 30 years after undergoing breast cancer surgery ...
Miyake T, Sasa H, Ito T, Watanabe T, Sato T, Ogata S, Takano M.   +6 more
europepmc   +2 more sources

The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer

Nature, 2022
Large-scale human genetic data1–3 have shown that cancer mutations display strong tissue-selectivity, but how this selectivity arises remains unclear. Here, using experimental models, functional genomics and analyses of patient samples, we demonstrate ...
Saroor A. Patel, Shoko Hirosue, Paulo Rodrigues, E. Vojtasova, E. Richardson, Jian-Feng Ge, S. E. Syafruddin, Alyson Speed, E. Papachristou, Dave J. Baker, David Clarke, Stephenie Purvis, L. Wesolowski, Anna Dyas, Leticia Castillon, Veronica Caraffini, D. Bihary, C. Yong, D. Harrison, Grant D. Stewart, M. Machiela, M. Purdue, S. Chanock, A. Warren, S. Samarajiwa, J. Carroll, S. Vanharanta   +26 more
semanticscholar   +1 more source

The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17

Science Signaling, 2022
PAX8 is a master transcription factor that is essential during embryogenesis and promotes neoplastic growth. It is expressed by the secretory cells lining the female reproductive tract, and its deletion during development results in atresia of ...
Daniele Chaves-Moreira, M. Mitchell, Cristina Arruza, Priyanka Rawat, Simone Sidoli, Robbin Nameki, J. Reddy, R. Corona, Lena K. Afeyan, Isaac A. Klein, Sisi Ma, B. Winterhoff, G. Konecny, Benjamin A. Garcia, Donita C. Brady, K. Lawrenson, P. Morin, R. Drapkin   +17 more
semanticscholar   +1 more source