Results 41 to 50 of about 11,551 (206)
Overexpression of platelet-derived growth factor receptor α in breast cancer is associated with tumour progression [PDF]
, 2005 Introduction Receptor tyrosine kinases have been extensively studied owing to their frequently abnormal activation in the development and progression of human cancers.
Inês Carvalho +32 more
core +2 more sources
Origins of T‐cell‐mediated autoimmunity in acquired aplastic anaemia
British Journal of Haematology, Volume 206, Issue 4, Page 1035-1053, April 2025.Acquired aplastic anaemia (AA) is an autoimmune bone marrow failure disease caused by a cytotoxic T‐cell–mediated attack on haematopoietic stem and progenitor cells (HSPCs). Despite significant progress in understanding T‐cell repertoire alterations in AA, the identification of specific pathogenic T cells remains elusive.
Aura Enache +2 more
wiley +1 more source
Brazilian Journal of Medical and Biological Research, 2003 Point mutations and small insertions or deletions in the human alpha-globin genes may produce alpha-chain structural variants and alpha-thalassemia.
S.B. Jorge +3 more
doaj +1 more source
Use of streptavidin magnetic beads in single strand conformation polymorphism profiles to detect mutations in rpoB gene of M.tuberculosis [PDF]
, 1998 Single strand conformation polymorphism (SSCP) is one of the promising techniques to identify mutations in short pieces of DNA (Orita et al. 1989). In this technique, DNA of interest is often amplified by the polymerase chain reaction (PCR) and then ...
Ding, B C +4 more
core
Cancer Reports, Volume 8, Issue 1, January 2025.ABSTRACT Background Changes in functional genetic polymorphisms may increase or decrease the risk of cancer in patients. Nowadays, the association between polymorphisms in the interleukin‐8 (IL‐8) gene and the susceptibility of cancer risk have been investigated in many studies, however, above relationships remain unclear. Aim The current study aims to
Bin Xu, Yidan Yan
wiley +1 more source
Haplotype association of ovine leptin gene on breeding value of body measurements in Makooei sheep breed [PDF]
Biotechnology in Animal Husbandry, 2014 The research was undertaken to find association of genetic variation in the exon 3 of the leptin gene and breeding value of body weight traits in Makooei sheep breed using single strand conformation polymorphism (SSCP).
Sadeghi S. +2 more
doaj
Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma [PDF]
, 2009 Signaling through the Notch1 receptor has a pivotal role in early thymocyte development. Gain of Notch1 function results in the development of T-cell acute lymphoblastic leukemia in a number of mouse experimental models, and activating Notch1 mutations ...
Chiba Shigeru +20 more
core +1 more source
[PGM1 genotyping by PCR-SSCP].
Fa yi xue za zhi, 2004 PGM1 genotyping by PCR-SSCP analysis.Amplified genome DNA from 156 unrelated Han individuals living in Wuhan, PCR products for exon 4 and exon 8 of PGM1 were then analyzed by SSCP to detect the genotypes.2 alleles and 3 genotypes were detected in exon 4 and 8 respectively. The discrimination power was 0.7318.
Hai-yan, Song +2 more
openaire +1 more source
An efficient CRISPR‐Cas12a‐mediated MicroRNA knockout strategy in plants
Plant Biotechnology Journal, Volume 23, Issue 1, Page 128-140, January 2025.Summary In recent years, the CRISPR‐Cas9 nuclease has been used to knock out MicroRNA (miRNA) genes in plants, greatly promoting the study of miRNA function. However, due to its propensity for generating small insertions and deletions, Cas9 is not well‐suited for achieving a complete knockout of miRNA genes.
Xuelian Zheng +14 more
wiley +1 more source
DFNB59 Gene Mutations and its Association with Deafness in Schoolchildren in Kohgilooyeh & Boyerahmad Province [PDF]
, 2010 Introduction & Objective: Hearing loss is a common disease affecting millions of people worldwide. Hearing loss can be caused due to genetic or environmental factors or even both.
Abolhasani, Marzieh. +8 more
core