Results 1 to 10 of about 4,063 (166)

The PA2803-encoded PcrP exhibits a novel non-catalytic function and contributes to polymyxin B resistance in P. aeruginosa [PDF]

Journal of Bacteriology
The opportunistic human pathogen Pseudomonas aeruginosa (Pa), a leading cause of severe infections, becomes increasingly resistant to antibiotics, including the last resort antibiotic, polymyxin B (PMB). Previous studies have shown that calcium (Ca2+) at
T. Salpadoru, S. Khanam, V. A. Borin, Ma. A. Achour, Denise Oh, M. Kanik, P. C. Gallage, A. Khanov, M. Hull, S. P. Pitre, P. K. Agarwal, M. J. Franklin, M. A. Patrauchan   +12 more
doaj   +4 more sources

pCRP-mCRP Dissociation Mechanisms as Potential Targets for the Development of Small-Molecule Anti-Inflammatory Chemotherapeutics [PDF]

Frontiers in Immunology, 2018
Circulating C-reactive protein (CRP) is a key acute-phase protein and one of the main clinical biomarkers for inflammation and infection. CRP is an important upstream mediator of inflammation and is associated with the onset of a number of important ...
Vittorio Caprio, Lina Badimon, Mario Di Napoli, Wen-Hui Fang, Glenn R. Ferris, Baoqiang Guo, Baoqiang Guo, Rocco S. Iemma, Donghui Liu, Donghui Liu, Yasmin Zeinolabediny, Yasmin Zeinolabediny, Mark Slevin, Mark Slevin, Mark Slevin, Mark Slevin   +15 more
doaj   +8 more sources

C-reactive protein: the nexus between inflammation and protein misfolding diseases [PDF]

Frontiers in Immunology
C-reactive protein (CRP), an acute-phase protein primarily produced by hepatocytes in response to pro-inflammatory cytokines, is a widely used clinical marker for inflammation and tissue damage. In its native state, CRP exists in a stable pentameric form
Abhishek Roy, Abhishek Roy, Johannes Zeller, Johannes Zeller, Tracy L. Nero, Tracy L. Nero, Tracy L. Nero, Johanna Klepetko, Steffen U. Eisenhardt, Michael W. Parker, Michael W. Parker, Michael W. Parker, James D. McFadyen, James D. McFadyen, James D. McFadyen, James D. McFadyen, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter   +19 more
doaj   +3 more sources

Human Fcγ-receptors selectively respond to C-reactive protein isoforms [PDF]

Frontiers in Immunology
IntroductionThe pentameric C-reactive protein (pCRP), an acute-phase protein, binds to lysophosphatidylcholine (LPC) displayed on the surface of dying cells and microorganisms to activate the complement system and to opsonize immune cells via Fcγ ...
Anna Henning, Johanna Seer, Johannes Zeller, Karlheinz Peter, Karlheinz Peter, Haizhang Chen, Julia Thomé, Philipp Kolb, Steffen U. Eisenhardt, Katja Hoffmann, Hartmut Hengel   +10 more
doaj   +3 more sources

C-reactive protein dissociation drives choroidal neovascularization in age-related macular degeneration [PDF]

Scientific Reports
Choroidal neovascularization (CNV) and inflammation play an important role in retinal disease development and the acute phase reactant C-reactive protein (CRP) has been shown to contribute to Age-related macular degeneration (AMD) in vitro.
Maria Hernandez, Sara Romero-Vázquez, Sergio Recalde, Jaione Bezunartea, Maite Moreno Orduña, Idoia Belza-Zuazu, Alfredo García-Layana, Alfredo Adán, Patricia Fernández-Robredo, Blanca Molins   +9 more
doaj   +3 more sources

C-reactive protein conformations and their association with the IL-1β/IL-6 pathway in ocular inflammatory conditions [PDF]

Frontiers in Immunology
IntroductionC-reactive protein (CRP) plays a critical role in the innate immune system and serves as a biomarker for various inflammatory conditions. CRP is a dynamic protein undergoing conformational changes between pentameric (pCRP) and monomeric (mCRP)
Mercedes S. Nabaes Jodar, Víctor Llorenç, Víctor Llorenç, Marc Figueras-Roca, Marc Figueras-Roca, Maite Sainz de-la-Maza, Maite Sainz de-la-Maza, Alfredo Adán, Alfredo Adán, Blanca Molins   +9 more
doaj   +3 more sources

A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation [PDF]

BMC Biology
Background C-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune ...
Ebru Karasu, Rebecca Halbgebauer, Lena Schütte, Johannes Greven, Felix M. Bläsius, Johannes Zeller, Oscar Winninger, David Braig, David Alexander Christian Messerer, Bettina Berger, Hendrik Feuerstein, Anke Schultze, Karlheinz Peter, Uwe Knippschild, Klemens Horst, Frank Hildebrand, Steffen U. Eisenhardt, Markus Huber-Lang   +17 more
doaj   +3 more sources

Redefining CRP in tissue injury and repair: more than an acute pro-inflammatory mediator [PDF]

Frontiers in Immunology
Most early studies investigating the role of C-reactive protein (CRP) in tissue damage determined it supported pro-hemostatic and pro-inflammatory activities.
Marc Potempa, Peter C. Hart, Ibraheem M. Rajab, Lawrence A. Potempa, Lawrence A. Potempa   +4 more
doaj   +3 more sources

Monomeric C-reactive protein as a biomarker for major depressive disorder [PDF]

Frontiers in Psychiatry, 2023
Neuroinflammation has been postulated to be a key factor in the pathogenesis of major depressive disorder (MDD). With this is mind, there has been a wave of research looking into pro-inflammatory mediators as potential biomarkers for MDD.
Mary G. Hornick, Lawrence A. Potempa
doaj   +3 more sources

The Effects of a Mindfulness-Based Intervention on Depression and Anxiety in the Long-COVID Population [PDF]

Journal of Patient-Centered Research and Reviews
Long-COVID is a complicated, post-viral syndrome involving multiple body systems and can present with neuropsychiatric symptoms. Little has been reported about the neuropsychiatric symptoms of long-COVID, and validated treatments do not yet exist.
Rachel Welbel, Elizabeth Rutha, Jeffrey Ording, Douglas Wang, Jana Hirschtick   +4 more
doaj   +3 more sources