Results 11 to 20 of about 766,818 (299)
Blocking interaction between SHP2 and PD‐1 denotes a novel opportunity for developing PD‐1 inhibitors [PDF]
EMBO Molecular Medicine, 2020 Small molecular PD‐1 inhibitors are lacking in current immuno‐oncology clinic. PD‐1/PD‐L1 antibody inhibitors currently approved for clinical usage block interaction between PD‐L1 and PD‐1 to enhance cytotoxicity of CD8+ cytotoxic T lymphocyte (CTL ...
Zhenzhen Fan +15 more
doaj +2 more sources
Siah2 control of T-regulatory cells limits anti-tumor immunity. [PDF]
, 2020 Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2-/- mice.
Aifantis, Ioannis +15 more
core +2 more sources
Revisiting the PD-1 pathway [PDF]
Science Advances, 2020 This review provides an overview of recent advances in understanding the interactions and signaling of PD-1 and its ligands.
Nikolaos Patsoukis +3 more
openaire +2 more sources
Frontiers in Immunology, 2022 Primary pulmonary lymphoepithelioma-like carcinoma (PLELC) is an Epstein–Barr virus (EBV)-related, rare subtype of non-small-cell lung cancer (NSCLC). Immune checkpoint inhibitors (ICI) show durable responses in advanced NSCLC. However, their effects and
Yu-Min Zhong +34 more
doaj +1 more source
Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses [PDF]
Cancer Immunology Research, 2021 Abstract PD-1 expression marks activated T cells susceptible to PD-1–mediated inhibition but not whether a PD-1–mediated signal is being delivered. Molecular predictors of response to PD-1 immune checkpoint blockade (ICB) are needed.
Xia Bu +14 more
openaire +2 more sources
USE OF NEAR INFRARED TECHNOLOGY TO PREDICT FATTY ACID GROUPS IN COMMERCIAL GROUND MEAT PRODUCTS [PDF]
Poljoprivreda, 2015 Near infrared transmittance (NIT, 850 to 1048 nm) spectroscopy was used to predict groups of fatty acids (FA), namely saturated FA (SFA), monounsaturated FA (MUFA) and polyunsaturated FA (PUFA), in commercial ground meat samples aiming to develope a fast
Sofia Ton +5 more
doaj +1 more source
Frontiers in Immunology, 2021 Immune checkpoint inhibitors, such as monoclonal antibodies targeting programmed death 1 (PD-1) and programmed death ligand-1 (PD-L1), have achieved enormous success in the treatment of several cancers.
Yuanyuan Wang +19 more
doaj +1 more source
PD-1 and PD-1 ligands: from discovery to clinical application [PDF]
International Immunology, 2007 Programmed cell death-1 (PD-1, Pdcd1), an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2.
Taku, Okazaki, Tasuku, Honjo
openaire +2 more sources
Onkologija, 2017 Protein programirane celične smrti 1:PD-1 (Programmed cell death protein 1) je transmembranski protein, ki je izražen na celicah T, B, NK ter monocitih in dendritičnih celicah.
Janja Ocvirk
doaj +1 more source
Italian Journal of Medicine, 2014 A 59-year old woman was admitted for fatigue and arm paresthesias with Trousseau sign. Her medical history included thyroidectomy and hypercholesterolemia recently treated with simvastatin.
Anna Piva +2 more
doaj +1 more source