Results 101 to 110 of about 12,266 (204)

Identifying Phosphodiesterase‐5 Inhibitors with Drug Repurposing Approach: Implications in Vasodysfunctional Disorders

ChemistryOpen
Phosphodiesterase type 5 (PDE5) is a multidomain protein that plays a crucial role in regulating cellular cyclic guanosine monophosphate (cGMP), a key signaling molecule involved in various physiological processes.
Mohd Shahnawaz Khan, Hamza Ahmad Mohammad, Moyad Shahwan, Dharmendra Kumar Yadav, Saleha Anwar, Dr. Anas Shamsi   +5 more
doaj   +1 more source

Phosphodiesterase Type 5 Inhibitors in Male Reproduction: Molecular Mechanisms and Clinical Implications for Fertility Management

Cells
Phosphodiesterases, particularly the type 5 isoform (PDE5), have gained recognition as pivotal regulators of male reproductive physiology, exerting significant influence on testicular function, sperm maturation, and overall fertility potential.
Aris Kaltsas, Fotios Dimitriadis, Athanasios Zachariou, Nikolaos Sofikitis, Michael Chrisofos   +4 more
doaj   +1 more source

Sildenafil dosed concomitantly with bosentan for adult pulmonary arterial hypertension in a randomized controlled trial [PDF]

, 2017
BACKGROUND: Few controlled clinical trials exist to support oral combination therapy in pulmonary arterial hypertension (PAH). METHODS: Patients with PAH (idiopathic [IPAH] or associated with connective tissue disease [APAH-CTD]) taking bosentan (62.5 ...
Dombi, Theresa, Jansa, Pavel, Teal, Simon, VIZZA, Carmine Dario, Zhou, Duo   +4 more
core   +1 more source

Natural phosphodiesterase 5 (PDE5) inhibitors: a computational approach

Natural Product Research, 2019
In 1998, sildenafil was marketed as the first FDA-approved oral drug for the treatment of erectile dysfunction (ED). During the last two decades, the commercialization of other synthetic phosphodiesterase 5 (PDE5) inhibitors has been paralleled by the rise of remedies based on natural molecules from different chemical classes (flavonoids, polyphenols ...
Ongaro, Alberto, Zagotto G., Memo M., Gianoncelli A., Ribaudo G.   +4 more
openaire   +2 more sources

Patient preference and satisfaction in erectile dysfunction therapy: a comparison of the three phosphodiesterase-5 inhibitors sildenafil, vardenafil and tadalafil

Patient Preference and Adherence, 2009
Amr Abdel Raheem1, Philip Kell21St. Peter’s Andrology Department, The Institute of Urology, London, and Cairo University, Egypt; 2St. Peter’s Andrology Department, The Institute of Urology, London, UKAbstract: Erectile dysfunction (ED)
Amr Abdel Raheem, Philip Kell
doaj  

Mechanism investigation of highly selective inhibitors toward phosphodiesterase 5 and 6 via the in vitro calculation and simulation

Frontiers in Chemistry
Introduction: In clinical practice, phosphodiesterase 5 (PDE5) inhibitors are commonly used to treat erectile dysfunction and pulmonary arterial hypertension.
Lihang Qu, Kaijian Sun, Zhouyu Jiang, Ting Wang, Linlin Chen, Chunjian Shen, Ruidong Gu   +6 more
doaj   +1 more source

Sildenafil helps the beat go on

Experimental Physiology, EarlyView.
Jules C. Hancox
wiley   +1 more source

Sildenafil Can Affect Innate and Adaptive Immune System in Both Experimental Animals and Patients

Journal of Immunology Research, 2017
Sildenafil, a type 5 phosphodiesterase inhibitor (PDE5-I), is primarily used for treating erectile dysfunction. Sildenafil inhibits the degradation of cyclic guanosine monophosphate (cGMP) by competing with cGMP for binding site of PDE5.
Monika Kniotek, Agnieszka Boguska
doaj   +1 more source

Research progress of phosphodiesterase 5 in heart failure [PDF]

Jichu yixue yu linchuang
Phosphodiesterase 5 (PDE5), a cyclic guanosine monophosphate (cGMP)-specific hydrolase, is targets cGMP produced by soluble guanosine cyclase (sGC) that is activated by nitric oxide (NO). It catalyzes the hydrolysis of the phosphodiester bond in cGMP and
YANG Yang, ZHANG Yarong, YANG Hongqin, WANG Jing, ZHAO Hongmei
doaj   +1 more source