Results 31 to 40 of about 8,404 (128)

Diet–Microbiome–Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications

Allergy, EarlyView.
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque, Liam O'Mahony, Inge Kortekaas Krohn, Charlotte G. Mortz, Markus Ollert, Mahesh S. Desai   +5 more
wiley   +1 more source

Development of a mini pig model of peanut allergy

Frontiers in Allergy
IntroductionThe prevalence of peanut allergies is increasing, emphasizing the need for an animal model to enhance our understanding of peanut allergy pathogenesis and to advance diagnostic tools and therapeutic interventions.
Akhilesh Kumar Shakya, Brittany Backus, Lazar D. Nesovic, Malini Mallick, Olivia Banister, Carla M. Davis, Sara Anvari, Harvinder Singh Gill   +7 more
doaj   +1 more source

Recent advances in understanding and preventing peanut and tree nut hypersensitivity [version 1; referees: 2 approved]

F1000Research, 2018
Peanut allergy, the most persistent and deadly of the food allergies, has become more prevalent worldwide in recent decades. Numerous explanations have been offered for the rise in peanut allergy, which has been more pronounced in Western, industrialized
Ayan Kusari, Allison Han, Lawrence Eichenfield   +2 more
doaj   +1 more source

Microbiota Signatures in Early Life and Their Association With Food Allergy: A Systematic Review

Allergy, EarlyView.
ABSTRACT Food allergy (FA) is increasing worldwide, and early life may be a critical window for immune training. We systematically reviewed observational human studies linking early‐life microbiota (infant, maternal, environmental, or extraintestinal) profiled using culture‐based and/or culture‐independent methods (including sequencing‐based approaches)
Eduard Flores Ventura, Jeremy Corriger, Hélène Omer, Marie Bodinier, Dirk Haller, Tomer Hertz, Martin Larsen, Maria Carmen Collado   +7 more
wiley   +1 more source

Production of Recombinant Peanut Allergen Ara h 2 using Lactococcus lactis

Microbial Cell Factories, 2007
Background Natural allergen sources can supply large quantities of authentic allergen mixtures for use as immunotherapeutics. However, such extracts are complex, difficult to define, vary from batch to batch, which may lead to unpredictable efficacy and ...
Frøkiær Hanne, Madsen Søren M, Kato Kentaro, Poulsen Lars K, Glenting Jacob, Wendt Camilla, Sørensen Helle W   +6 more
doaj   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

The safety and efficacy of oral immunotherapy compared to epicutaneous immunotherapy in peanut allergen desensitisation amongst the paediatric cohort—a narrative review

Frontiers in Allergy
Peanut allergies result from a type 1 hypersensitivity reaction, with a prevalence of approximately 1% in children under 5 years of age. The allergens that instigate this reaction are the peanut proteins (Ara h 1–Ara h 8) for which IgE antibodies are ...
Ehtesam A. Chowdhury, Olivia C. Jadeja
doaj   +1 more source

Diverging in Vivo Immune Response Patterns After Oral Food Challenge in Peanut Allergic Adults

Clinical &Experimental Allergy, EarlyView.
After the oral food challenge, peanut (PN)‐allergic adults were monitored over 4 weeks, which revealed diverging immune response patterns, with strong responders (SR) exhibiting heightened Ara h 2+ B cell expansion, PN sIgE induction and increasing PN‐specific Tconv. Weak responders (WR) had more activated PN‐specific Tregs.
Florent Fauchère, Aikaterina Alexiou, Veronika Höfer, Kirsten Beyer, Sabine Dölle‐Bierke, Andreas Thiel, Margitta Worm, Julian Braun   +7 more
wiley   +1 more source

HLA variation associated with peanut allergy and anaphylaxis among non-Hispanic Black individuals

Journal of Allergy and Clinical Immunology: Global
Background: Peanut is a major cause of food allergy. HLA genes have been consistently associated with peanut allergy in association studies. To date, however, there have been very few genetic studies of peanut allergy in non-Hispanic Black (Black ...
Baojun Wu, PhD, Mao Yang, MS, Donglei Hu, PhD, Ray Zhang, Bin Liu, PhD, MPH, Samantha Hochstadt, MS, David E. Lanfear, MD, MS, Jonathan Witonsky, MD, MAS, Rajesh Kumar, MD, MS, Jill A. Hollenbach, PhD, MPH, Esteban G. Burchard, MD, MPH, Elad Ziv, MD, L. Keoki Williams, MD, MPH, MBA   +12 more
doaj   +1 more source

Cross-reactive Carbohydrate Determinant Contributes to the False Positive IgE Antibody to Peanut

Allergology International, 2005
Background: The importance of peanut allergy has not been well recognized in Japanese society. IgE antibody to peanut can be, however, detected in patients without clinical peanut allergy. Methods: Clinical characteristics of 14 patients (aged 1–8 years)
Komei Ito, Masashi Morishita, Mihoko Ohshima, Tatsuo Sakamoto, Akira Tanaka   +4 more
doaj   +1 more source