Results 71 to 80 of about 3,098,750 (348)
ACSS2 involved in acetyl‐CoA synthesis regulates skeletal muscle function
The enzyme acyl‐coenzyme A synthetase short‐chain family member‐2 (ACSS2) catalyzes the conversion of acetate to acetyl‐CoA, but its function in skeletal muscle is unclear. We studied ACSS2 deficiency in mouse and fly models. Skeletal muscle from the mouse model showed atrophic fibers, excess lipid, and depleted NADH.
Mekala Gunasekaran+6 more
wiley +1 more source
Blockchain-enabled KYC integration for CLV optimization with robust M-Estimation and IRLS method
This research introduces an innovative approach in implementing Know Your Customer (KYC) on blockchain technology as a means of using data, hybrid robust m-estimation, and the iteratively reweighted less squares (IRLS) method to optimize CLV data.
Marischa Elveny+3 more
doaj +1 more source
Peer Review and the PJOHNS: Principles, Problems, and Promise
The Philippine Journal of Otolaryngology Head and Neck Surgery (PJOHNS) is the official refereed journal of the Philippine Society of Otolaryngology Head and Neck Surgery (PSOHNS).
José Florencio F. Lapeña
doaj +1 more source
Instructional activity created by UCLA Library in support of International Open Access Week 2019. This actitivy takes users through a game of chance centered around the scholarly peer review process.
Chan, Jennifer
core
Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke+2 more
wiley +1 more source
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican+7 more
wiley +1 more source
Peer review : organisational learning for nurses : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Nursing at Massey University [PDF]
Organisational learning as it relates to the development of a peer review system within a clinical area of nursing practice is the focus of this study.
McRae, Brigid Halmai Te Kahui
core
Context: Peer-assisted learning (PAL) has been shown to benefit students across educational levels. Current research has investigated perceptions of PAL, postgraduate impact, as well as prevalence.
Bates, Dana K.
core +1 more source
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona+4 more
wiley +1 more source
Peer review: types, pitfalls and controversies
Peer review has been adopted by most journals to evaluate the quality of submitted manuscripts, for which peer reviewers aim to provide a critical, independent and unbiased assessment. Peer review is ever evolving, with no single peer review system being
Wilfred C. G. Peh
doaj +1 more source