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Dual character of surface engineering on SN38 prodrug nano-assemblies: divergent effects on in vitro and in vivo behavior [PDF]
Military Medical ResearchBackground Surface engineering has emerged as a promising strategy to enhance the performance of nanomedicines. In particular, the PEGylation levels for chemotherapy drug 7-Ethyl-10-hydroxycamptothecin (SN38) prodrug nanoparticles (NPs) play a crucial ...
Ya-Qiao Li +11 more
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PEGylation technology: addressing concerns, moving forward [PDF]
Drug DeliveryPEGylation technology, that is grafting of poly(ethylene glycol)(PEG) to biologics, vaccines and nanopharmaceuticals, has become a cornerstone of modern medicines with over thirty products used in the clinic.
Dmitri Simberg +5 more
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Blood clearance and tissue distribution of PEGylated and non-PEGylated gold nanorods after intravenous administration in rats\ud [PDF]
, 2011 Aims: To develop and determine the safety of gold nanorods, whose aspect ratios can be tuned to obtain plasmon peaks between 650 and 850 nm, as contrast enhancing agents for diagnostic and therapeutic applications.
Jong, Wim H. de +7 more
core +16 more sources
DEVELOPMENT OF DELIVERY SYSTEM FOR TRANSFERRIN USING CHEMICAL MODIFICATION APPROACH [PDF]
Basrah Journal of Veterinary Research, 2012 Proteins are very important molecules as therapeutics. They have several advantages over small molecule drugs but their use is limited by their circulation short half life, immunogenicity and physicochemical instability.
Athmar D. Habeeb
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Optimization of Ultra-Small Nanoparticles for Enhanced Drug Delivery
BIO Integration, 2023 Nanoparticle delivery of drugs to the brain is hindered by the blood-brain barrier (BBB). In malignant glioma (MG), small disruptions in the BBB may allow nanoparticles smaller than 20 nm to penetrate the dysfunctional barrier.
Shishi He +7 more
doaj +1 more source
Investigation of the Effect of PEG Detoxification on Diphtheria Vaccine [PDF]
Archives of Razi Institute, 2022 Immunization has been considered a successful global health program that saves many persons’ lives each year. The vaccines reduce the risk of getting the disease by building immunity in the body. Therefore, the constant availability of essential vaccines
T Hesari +6 more
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Безопасность и риск фармакотерапии, 2021 Currently, there are no efficacious, all-purpose antiviral medicines for the treatment of ocular surface infections caused by viruses. At the same time, type III interferons demonstrate high potency for histological barriers, such as the conjunctiva ...
N. A. Kikhtenko +6 more
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Polyethylene Glycol Camouflaged Earthworm Hemoglobin. [PDF]
, 2017 Nearly 21 million components of blood and whole blood and transfused annually in the United States, while on average only 13.6 million units of blood are donated. As the demand for Red Blood Cells (RBCs) continues to increase due to the aging population,
Cabrales, Pedro +8 more
core +8 more sources
Noncovalent PEGylation of l-Asparaginase Using PEGylated Polyelectrolyte [PDF]
Journal of Pharmaceutical Sciences, 2015 Noncovalent PEGylation has great potential for stabilization of therapeutic proteins. Here, we demonstrated that the noncovalent PEGylation with a PEGylated polyelectrolyte stabilized a therapeutic protein, l-asparaginase (ASNase). Anionic ASNase and cationic poly(ethylene glycol)-block-poly(N,N-dimethylaminoethyl methacrylate) (PEG-b-PAMA) formed a ...
Takaaki, Kurinomaru, Kentaro, Shiraki
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To PEGylate or Not To PEGylate Therapeutics? [PDF]
Cell Chemical Biology, 2019 PEGylation is a common modulator of pharmacokinetics for therapeutic agents in vivo. In this issue of Cell Chemical Biology, Moreno et al. (2019) show anti-PEG antibodies may directly inhibit the activity of a PEGylated aptamer, RB006, both in vitro and in vivo, and the issues surrounding anti-PEG antibodies are discussed.
Keith E, Maier +2 more
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