PEGylation technology: addressing concerns, moving forward [PDF]
Drug DeliveryPEGylation technology, that is grafting of poly(ethylene glycol)(PEG) to biologics, vaccines and nanopharmaceuticals, has become a cornerstone of modern medicines with over thirty products used in the clinic.
Dmitri Simberg +5 more
doaj +3 more sources
The cellular interactions of PEGylated gold nanoparticles : effect of PEGylation on cellular uptake and cytotoxicity [PDF]
, 2014 Poly(ethylene glycol) (PEG) is frequently used to coat various medical nanoparticles (NPs). As PEG is known to minimize NP interactions with biological specimens, the question remains whether PEGylated NPs are intrinsically less toxic or whether this is ...
Abdelmonem, Abuelmagd M +10 more
core +3 more sources
Dual character of surface engineering on SN38 prodrug nano-assemblies: divergent effects on in vitro and in vivo behavior [PDF]
Military Medical ResearchBackground Surface engineering has emerged as a promising strategy to enhance the performance of nanomedicines. In particular, the PEGylation levels for chemotherapy drug 7-Ethyl-10-hydroxycamptothecin (SN38) prodrug nanoparticles (NPs) play a crucial ...
Ya-Qiao Li +11 more
doaj +2 more sources
Multimerization through Pegylation Improves Pharmacokinetic Properties of scFv Fragments of GD2-Specific Antibodies [PDF]
Molecules, 2019 Antigen-binding fragments of antibodies specific to the tumor-associated ganglioside GD2 are well poised to play a substantial role in modern GD2-targeted cancer therapies, however, rapid elimination from the body and reduced affinity compared to full ...
Irina V. Kholodenko +9 more
doaj +2 more sources
Supramolecular PEGylation of biopharmaceuticals [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Pharmaceutical practice has transitioned away from small-molecule drugs to the use of biomolecules (peptides, proteins, and antibodies). Where formulation of small molecules focused primarily on solubility, biopharmaceuticals introduced an array of complications due to their more complex secondary and tertiary structures ...
Matthew J. Webber +8 more
openalex +4 more sources
PEGylation of polymerized albumin retains colloid osmotic pressure: Towards an enhanced potential plasma substitute. [PDF]
Biotechnol ProgAbdalbaqi A +7 more
europepmc +3 more sources
DEVELOPMENT OF DELIVERY SYSTEM FOR TRANSFERRIN USING CHEMICAL MODIFICATION APPROACH [PDF]
Basrah Journal of Veterinary Research, 2012 Proteins are very important molecules as therapeutics. They have several advantages over small molecule drugs but their use is limited by their circulation short half life, immunogenicity and physicochemical instability.
Athmar D. Habeeb
doaj +1 more source
Optimization of Ultra-Small Nanoparticles for Enhanced Drug Delivery
BIO Integration, 2023 Nanoparticle delivery of drugs to the brain is hindered by the blood-brain barrier (BBB). In malignant glioma (MG), small disruptions in the BBB may allow nanoparticles smaller than 20 nm to penetrate the dysfunctional barrier.
Shishi He +7 more
doaj +1 more source
Investigation of the Effect of PEG Detoxification on Diphtheria Vaccine [PDF]
Archives of Razi Institute, 2022 Immunization has been considered a successful global health program that saves many persons’ lives each year. The vaccines reduce the risk of getting the disease by building immunity in the body. Therefore, the constant availability of essential vaccines
T Hesari +6 more
doaj +1 more source
Безопасность и риск фармакотерапии, 2021 Currently, there are no efficacious, all-purpose antiviral medicines for the treatment of ocular surface infections caused by viruses. At the same time, type III interferons demonstrate high potency for histological barriers, such as the conjunctiva ...
N. A. Kikhtenko +6 more
doaj +1 more source