Results 101 to 110 of about 33,392 (283)

Conformation and aggregation of selectively PEGylated and lipidated gastric peptide hormone human PYY3–36 [PDF]

, 2018
The gastric peptide hormone human PYY3–36 is a target for the development of therapeutics, especially for treatment of obesity. The conformation and aggregation behavior of PEGylated and lipidated derivatives of this peptide are examined using a ...
Beck-Sickinger, Annette G., Bellmann-Sickert, Kathrin, Castelletto, Valeria, Hamley, Ian W., Harris, Gemma, Ruokolainen, Janne, Seitsonen, Jani   +6 more
core   +2 more sources

CRISPR‐Cas9‐Loaded Theranostic Liposomes for Enhancing Radiosensitization of Prostate Cancer through POLD4 Gene Editing under Real‐Time MRI Monitoring

Advanced Science, EarlyView.
This study identifies POLD4 as a potential prostate cancer radiosensitization target through transcriptome sequencing. By encapsulating POLD4‐targeted CRISPR/Cas9 plasmids and USPIONs in cationic liposomes, an MRI‐monitored gene‐editing platform is established.
Xuhui Fan, Ruru Zhang, Linjun Yang, Shixiong Chen, Meijuan He, Yongqiang Wang, Linjie Huang, Jianfeng Zeng, Shuwang Wu, Mingyuan Gao, Han Wang   +10 more
wiley   +1 more source

Design, Synthesis and Characterization of Nano niosomal Delivery system Containing paclitaxel drug for Drug Delivery to Osteosarcoma Cell Line (Saos-2)

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2022
Introduction: Osteosarcoma is the most common type of bone cancer which current chemotherapy treatment strategies have not been very successful due to multiple drug resistance and diverse side effects.
Mohammad Javad Pourmahmoudian, Seyed Mahdi Kalantar, Bibi Fatemeh Haghiralsadat   +2 more
doaj  

Preclinical study of the toxicity of the oral form of pegylated interferon α-2b under its long-term use

Сибирский научный медицинский журнал, 2019
The aim of the study is to investigate the chronic toxicity of the oral finished dosage form of pegylated interferon α-2b, obtained with the help of electron-beam synthesis technology. Materials and methods.
A. A. Churin, E. Y. Sherstoboev, D. N. Kinsht, T. S. Tartynova, P. G. Madonov   +4 more
doaj   +1 more source

Physicochemical and Biological Evaluation of siRNA Polyplexes Based on PEGylated Poly(amido amine)s [PDF]

, 2011
Purpose: Use of RNA interference as novel therapeutic strategy is hampered by inefficient delivery of its mediator, siRNA, to target cells. Cationic polymers have been thoroughly investigated for this purpose but often display unfavorable characteristics
Gert Storm, Johan F. J. Engbersen, Leonardus J. van der Aa, Pieter Vader, Raymond M. Schiffelers   +4 more
core   +4 more sources

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Stealth monoolein-based nanocarriers for delivery of siRNA to cancer cells [PDF]

, 2015
While the delivery of small interfering RNAs (siRNAs) is an attractive strategy to treat several clinical con- ditions, siRNA-nanocarriers stability after intravenous administration is still a major obstacle for the development of RNA-interference based ...
Allen, Ana C.N. Oliveira, Anbazhagan, Andreia C. Gomes, Bedi, Braeckmans, Braet, Bruno, Buyens, Buyens, Caracciolo, Carneiro, Chen, Cláudia Botelho, Copeland, Dominska, Fire, Grimm, Hafez, Hyvönen, Ivo Lopes, Kevin Braeckmans, Khatri, Koen Raemdonck, Koen Rombouts, Koynova, Kundu, Lam, Lassiseraye, Lau, Leal, Li, Li, Luzzati, M. Elisabete C.D. Real Oliveira, Marlene Lúcio, Mendonça, Mendonça, Naeye, Naeye, Oberle, Oliveira, Oliveira, Peeters, Pfaffl, Rejman, Remaut, Remaut, Resnier, Romberg, Rosana Simón-Vázquez, Shi, Silva, Silva, Silva, Silva, Silvius, Silvius, Simón-Vázquez, Song, Thomas Martens, Tseng, Vellón, Wang, Weisman, Wheeler, Whitehead, Yuan, Yuan, Zuhorn, África González-Fernández   +70 more
core   +1 more source

Overcoming PEG Antigenicity: Statistical PEG Isomers Reduce Antibody Binding

Advanced Science, EarlyView.
Conventional poly(ethylene glycol) (PEG) is commonly applied in biomedicine, but is now known to induce antibody formation. Here, it is shown that the development of “randomized PEG” (rPEG) featuring glycidyl methyl ether (GME) comonomers decreased antibody binding.
Mareike Deuker, Dominik Schulz, Kaloian Koynov, Svenja Morsbach, Holger Frey, Katharina Landfester   +5 more
wiley   +1 more source

Targeting Pancreatic Cancer Cells and Stellate Cells Using Designer Nanotherapeutics in vitro

International Journal of Nanomedicine, 2020
Chandra Kumar Elechalawar,1 Md Nazir Hossen,1 Priya Shankarappa,2 Cody J Peer,2 William D Figg,2 J David Robertson,3 Resham Bhattacharya,4 Priyabrata Mukherjee1,5 1Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City,
Elechalawar CK, Hossen MN, Shankarappa P, Peer CJ, Figg WD, Robertson JD, Bhattacharya R, Mukherjee P   +7 more
doaj  

Targeting kidney mesangium by nanoparticles of defined size [PDF]

, 2011
Nanoparticles are being investigated for numerous medical applications and are showing potential as an emerging class of carriers for drug delivery. Investigations on how the physicochemical properties (e.g., size, surface charge, shape, and density of ...
C. H. J. Choi, Chen, Choi, Davis, Davis, J. E. Zuckerman, Kanwar, Lahdenkari, Luft, M. E. Davis, Nurkiewicz, Ogawa, P. Webster, Peer, Ruckerl, Schipper, Schreiner, Soo Choi, Tan, Zimmermann   +19 more
core   +2 more sources