Results 31 to 40 of about 31,898 (250)

Structure-based antigenic epitope and PEGylation improve the efficacy of staphylokinase

Microbial Cell Factories, 2017
Staphylokinase (Sak) holds promise for use in thrombolytic therapy for acute myocardial infarction. However, its immunogenicity is a major disadvantage under clinical conditions.
Yanying Xu, Yueyuan Shi, Jianzhong Zhou, Wei Yang, Lei Bai, Shilei Wang, Xin Jin, Qiangsi Niu, Ailong Huang, Deqiang Wang   +9 more
doaj   +1 more source

Nanoparticles in the treatment of chronic lung diseases [PDF]

, 2019
Nanoparticles, although considered a topic of modern medicine, actually have an interesting history. Currently, advances in nanomedicine hold great promise as drug carrier systems for sustained release and targeted delivery of diverse therapeutic agents.
Alexescu, Teodora G, Cosnarovici, Maria, Negrean, Vasile, Orasan, Olga H, Para, Ioana, Perne, Mirela G, Popovici, Ionela, Ruta, Victoria M, Tarmure, Simina, Todea, Doina A   +9 more
core   +2 more sources

Dual pH- and GSH-Responsive Degradable PEGylated Graphene Quantum Dot-Based Nanoparticles for Enhanced HER2-Positive Breast Cancer Therapy

Nanomaterials, 2020
Dual stimuli-responsive degradable carbon-based nanoparticles (DS-CNPs) conjugated with Herceptin (HER) and polyethylene glycol (PEG) have been designed for the treatment of HER2-positive breast cancer.
Na Re Ko, Se Young Van, Sung Hwa Hong, Seog-Young Kim, Miran Kim, Jae Seo Lee, Sang Ju Lee, Yong-kyu Lee, Il Keun Kwon, Seung Jun Oh   +9 more
doaj   +1 more source

Escherichia coli TatA and TatB Proteins Have N-out, C-in Topology in Intact Cells [PDF]

, 2012
The twin arginine protein transport (Tat) system translocates folded proteins across the cytoplasmic membrane of prokaryotes and the thylakoid membrane of chloroplasts.
Alami, Bartolomé, Bauer, Berks, Bernhardt, Berthelmann, Bogsch, Bolhuis, Bryson, Buchanan, Casadaban, Chan, Cline, Cline, Dabney-Smith, Dabney-Smith, de Leeuw, De Leeuw, Gohlke, Gouffi, Greene, Hashimoto-Gotoh, Heijne, Hu, Ize, Jack, Jack, Laemmli, Leake, Lee, Leive, Lu, Maegawa, Maldonado, Mori, Mori, Palmer, Palmer, Porcelli, Punginelli, Richter, Sambrook, Sargent, Sargent, Sargent, Sauvé, Silvestro, Simons, Stanley, Stevenson, Tarry, Tarry, Towbin, Walther, Wang, Weiner, Wessel, Wexler, Yen   +58 more
core   +3 more sources

Determination of the degree of PEGylation of protein bioconjugates using data from proton nuclear magnetic resonance spectroscopy

Data in Brief, 2019
The average number of methoxy poly(ethylene glycol) (mPEG) chains grafted to a protein – also known as the degree of PEGylation – is a fundamental parameter for characterizing a bioconjugate.
Ahlem Zaghmi, Andrea A. Greschner, Eduardo Mendez-Villuendas, Jun Yang Liu, Hendrick W. de Haan, Marc A. Gauthier   +5 more
doaj   +1 more source

Synthesis of PEGylated Human Serum Albumin by Maleimide-Thiol Chemistry and Histopathological Evaluation in a Mice Model of Carrageenan-Induced Inflammation [PDF]

Trends in Pharmaceutical Sciences, 2019
Occasional incompetence of human serum albumin (HSA) as a plasma expander is linked to severity of the underlying endothelial cell injury so that HSA can readily extravasate if structural integrity of the endothelial is compromised.
Mehdi Hoorang, Alimohammad Tamaddon, Gholamhosein Yousefi   +2 more
doaj   +1 more source

Preparation of poly-l-lysine-based nanoparticles with pH-sensitive release of curcumin for targeted imaging and therapy of liver cancer in vitro and in vivo

Drug Delivery, 2018
Poly-l-lysine (PLL) nanoparticle (NP) system was prepared for the controlled release of curcumin (CUR) by pH stimuli, and its theranostic efficacy on cancer was compared to that of CUR solution in vitro and in vivo.
Dae Hyeok Yang, Hyun Joo Kim, Kyeongsoon Park, Jae Kwang Kim, Heung Jae Chun   +4 more
doaj   +1 more source

Er:Y₂O₃ and Nd:Y₂O₃ Nanoparticles: Synthesis, Pegylation, Characterization and Study of Their Luminescence Properties

Chemosensors, 2022
Lanthanide-doped yttrium oxide nanoparticles can display selective upconversion properties, rendering them invaluable in the field of nanomedicine for both sensing and diagnostics.
Regina Maria Chiechio, Rosalia Battaglia, Angela Caponnetto, Ester Butera, Giorgia Franzò, Riccardo Reitano, Michele Purrello, Marco Ragusa, Davide Barbagallo, Cristina Barbagallo, Cinzia Di Pietro, Valérie Marchi, Maria José Lo Faro, Annalinda Contino, Giuseppe Maccarrone, Paolo Musumeci   +15 more
doaj   +1 more source

Long acting growth hormone (LAGH), an update

Frontiers in Pediatrics, 2023
In 1957, Maurice Raben at Yale was able to isolate and purify growth hormone from cadaveric pituitary glands. Pituitary growth hormone was the only way to treat children with growth hormone (GH) deficiency, until 1985 when recombinant GH became available
Margaret Steiner Grillo, Jacklyn Frank, Paul Saenger   +2 more
doaj   +1 more source

Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]

, 2011
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core   +1 more source