Results 41 to 50 of about 31,898 (250)
PEGylated Systems in Pharmaceutics [PDF]
Polymer Science, Series C, 2020 This review addresses the use of poly(ethylene glycol) (PEG) and PEG conjugation for the design of novel dosage forms and the modification of biomolecules. The peculiarities of PEGylated nanoparticles, liposomes, proteins, enzymes, and small drug and polyelectrolyte molecules and their influence on systemic drug delivery, including overcoming of ...
Porfiryeva, N. N. +2 more
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Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy
Pharmaceutics, 2020 Here, a novel protonable copolymer was realized for the production of polyplexes with a siRNA (inhibitor of STAT6 expression in asthma), with the aim of a pulmonary administration.
Emanuela Fabiola Craparo +4 more
doaj +1 more source
Size Control and Fluorescence Labeling of Polydopamine Melanin-Mimetic Nanoparticles for Intracellular Imaging. [PDF]
, 2017 As synthetic analogs of the natural pigment melanin, polydopamine nanoparticles (NPs) are under active investigation as non-toxic anticancer photothermal agents and as free radical scavenging therapeutics.
Amin, Devang +3 more
core +3 more sources
Бюллетень сибирской медицины, 2014 The development of optimal experimental therapeutic schemes of immobilized interferon α-2b (production of JSC «Siberian Center for Pharmacology and Biotechnology», Novosibirsk) administration was conducted in the frame of the common program of pre ...
O. G. Shitikova +9 more
doaj +1 more source
Pharmacokinetic Consequences of Pegylation [PDF]
Drug Delivery, 2006 Pegylation, generally described as the molecular attachment of polyethylene glycols (PEGs) with different molecular weights to active drug molecules or surface treatment of drug-bearing particles with PEGs, is one of the most promising and extensively studied strategies with the goal of improving the pharmacokinetic behavior of the therapeutic drugs. A
Mehrdad, Hamidi +2 more
openaire +2 more sources
Molecules, 2020 In our work, we developed the synthesis of new polyfunctional pegylated trehalose derivatives and evaluated their cryoprotective effect using flow cytometry.
Karel Pomeisl +3 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 The biological activity of antimicrobial peptides and proteins is closely related to their structural aspects and is sensitive to certain post-translational modifications such as glycosylation, lipidation and PEGylation.
Júlio César Moreira Brito +9 more
doaj +1 more source
, 2011 Biomaterials are often soft materials. There is now growing interest in designing, synthesizing and characterising soft materials that mimic the properties of biological materials such as tissue, proteins, DNA or cells. Research on biomimetic soft matter
Hamley, Ian
core +1 more source
Surface functionalization with polyethylene glycol and polyethyleneimine improves the performance of graphene-based materials for safe and efficient intracellular delivery by laser-induced photoporation [PDF]
, 2020 Nanoparticle mediated laser-induced photoporation is a physical cell membrane disruption approach to directly deliver extrinsic molecules into living cells, which is particularly promising in applications for both adherent and suspension cells.
Boukherroub, Rabah +10 more
core +2 more sources
Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery
Scientific Reports, 2017 A new acidly sensitive PEGylated polyethylenimine linked by Schiff base (PEG-s-PEI) was designed to render pH-sensitive PEGylation nanoassemblies through multiple interactions with indomethacin and docetaxel (DTX).
Guanren Zhao +8 more
doaj +1 more source