Results 31 to 40 of about 161,137 (307)

Proof of concept for the clinical effects of oral rilzabrutinib, the first Bruton tyrosine kinase inhibitor for pemphigus vulgaris: the phase II BELIEVE study

British Journal of Dermatology, 2021
Bruton tyrosine kinase (BTK) inhibition targets B‐cell and other non‐T‐cell immune cells implicated in the pathophysiology of pemphigus, an autoimmune disease driven by anti‐desmoglein autoantibodies.
D. Murrell, A. Patsatsi, P. Stavropoulos, S. Baum, T. Zeeli, J. Kern, A. Roussaki-Schulze, R. Sinclair, I. Bassukas, D. Thomas, A. Neale, P. Arora, F. Caux, V. Werth, S. Gourlay, P. Joly   +15 more
semanticscholar   +1 more source

Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion. [PDF]

, 2013
Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of ...
Hartlieb, Eva, Kempf, Bettina, Partilla, Miriam, Spindler, Volker, Vigh, Balázs, Waschke, Jens   +5 more
core   +6 more sources

S2k guidelines for the treatment of pemphigus vulgaris/foliaceus and bullous pemphigoid: 2019 update

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2020
(1) Department of Dermatology, University of Lübeck, Lübeck, Germany (2) Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany (3) Department of Dermatology, University Hospital Erlangen, Erlangen, Germany (4) Department of ...
Enno Schmidt, M. Sticherling, Miklós Sárdy, Rüdiger Eming, Matthias Goebeler, M. Hertl, Silke C. Hofmann, N. Hunzelmann, Johannes S. Kern, Harald Kramer, A. Nast, Hans‐Dieter Orzechowski, Christiane Pfeiffer, Volker Schuster, C. Sitaru, Miriam Zidane, D. Zillikens, M. Worm   +17 more
semanticscholar   +1 more source

Post-Pemphigus Acanthomata Presenting as an Isolated, Hyperkeratotic Plaque

Dermatopathology, 2023
Post-pemphigus acanthomas have been rarely discussed in the literature. A prior case series identified 47 cases of pemphigus vulgaris and 5 cases of pemphigus foliaceus, out of which 13 developed acanthomata as a part of the healing process. Additionally,
Rachita Pandya, Yanjia Zhou, Mansee Desai, Nancy Anderson, Ashley Elsensohn   +4 more
doaj   +1 more source

Mucosal-dominant pemphigus vulgaris in a captopril-taking woman with angioedema [PDF]

Anais Brasileiros de Dermatologia, 2015
We describe a 39-year-old woman with an apparent captopril-induced, contact mucosal-dominant pemphigus vulgaris and angioedema, who took captopril during a bout of arterial hypertension.
Justyna Gornowicz-Porowska, Marian Dmochowski, Pawel Pietkiewicz, Monika Bowszyc-Dmochowska   +3 more
doaj   +2 more sources

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Pemphigus vulgaris and focal segmental glomerulosclerosis (FSGS): First reported case and a review of the literature

Clinical Case Reports, 2023
Key Clinical Message There may be a connection between pemphigus vulgaris and nephrotic syndrome, as evidenced by the occurrence of focal segmental glomerulosclerosis in our pemphigus vulgaris patient and reviewing relevant literature.
Afsaneh Sadeghzadeh‐Bazargan, Atefeh Amouzegar, Maryam Abolhasani, Abbas Dehghani, Azadeh Goodarzi, Seyyedeh Tahereh Rahimi   +5 more
doaj   +1 more source

Relationship Between Pemphigus Vulgaris Severity and PCR-positive Herpes Simplex Virus

Acta Dermato-Venereologica, 2022
Pemphigus vulgaris is a rare autoimmune skin disease. Although herpes simplex virus has been associated with autoimmune diseases, evidence regarding its association with pemphigus vulgaris exacerbations is scarce. This retrospective cohort study aimed to
Sharon Baum, Itai Atar, Dan Coster, Sara Dovrat, Michal Solomon, Eli Sprecher, Tal Zeeli, Aviv Barzilai   +7 more
doaj   +1 more source

Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]

, 2003
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R., Braungart, E., Degitz, K., Douwes, K., Flaig, M. J., Magdolen, V., Probst, C., Sander, C. A., Schuh, T., Wosikowski, K.   +9 more
core   +1 more source

Bullous pemphigoid and pemphigus vulgaris--incidence and mortality in the UK: population based cohort study. [PDF]

, 2008
OBJECTIVE: To determine the incidence of and mortality from bullous pemphigoid and pemphigus vulgaris in the United Kingdom. DESIGN: Retrospective historical cohort study. SETTING: Computerised medical records from the health improvement network, a large
Fleming, KM, Hubbard, R, Langan, SM, Smeeth, L, Smith, CJ, West, J   +5 more
core   +2 more sources