Restricted Sequence Variation in
mSphere, 2020 A recent clinical report has linked Streptococcus pyogenes β-lactam antibiotic resistance to mutation in the penicillin binding protein (PBP) PBP2x. To determine whether this is an isolated case or reflects a broader prevalence of mutations that might ...
Andrew Hayes +4 more
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Penicillin Binding Proteins and β-Lactamases of Mycobacterium tuberculosis: Reexamination of the Historical Paradigm [PDF]
mSphere, 2022 Penicillin binding proteins (PBPs) have been extensively studied due to their importance to the physiology of bacterial cell wall peptidoglycan and as targets of the most widely used class of antibiotics, the β-lactams. The existing paradigm asserts that
Gaurav Kumar +4 more
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Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials [PDF]
Antibiotics, 2016 Peptidoglycan (PG) is an essential macromolecular sacculus surrounding most bacteria. It is assembled by the glycosyltransferase (GT) and transpeptidase (TP) activities of multimodular penicillin-binding proteins (PBPs) within multiprotein complex ...
Eric Sauvage, Mohammed Terrak
doaj +3 more sources
β-Lactam Resistance in ESKAPE Pathogens Mediated Through Modifications in Penicillin-Binding Proteins: An Overview. [PDF]
Infect Dis Ther, 2023 Bacteria acquire β-lactam resistance through a multitude of mechanisms among which production of β-lactamases (enzymes that hydrolyze β-lactams) is the most common, especially in Gram-negatives.
Sethuvel DPM +6 more
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Class-A penicillin binding proteins do not contribute to cell shape but repair cell-wall defects. [PDF]
Elife, 2020 Cell shape and cell-envelope integrity of bacteria are determined by the peptidoglycan cell wall. In rod-shaped Escherichia coli, two conserved sets of machinery are essential for cell-wall insertion in the cylindrical part of the cell: the Rod complex ...
Vigouroux A +10 more
europepmc +2 more sources
Relationship between Penicillin-Binding Proteins Alterations and β-Lactams Non-Susceptibility of Diseased Pig-Isolated Streptococcus suis [PDF]
Antibiotics, 2023 Streptococcus suis is a zoonotic pathogen causing disease in both animals and humans, and the emergence of increasingly resistant bacteria to antimicrobial agents has become a significant challenge globally. The objective of this study was to investigate
Kamonwan Lunha +5 more
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Distinctive Binding of Avibactam to Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria [PDF]
Antimicrobial Agents and Chemotherapy, 2015 Avibactam is a novel non-β-lactam β-lactamase inhibitor that covalently acylates a variety of β-lactamases, causing inhibition. Although avibactam presents limited antibacterial activity, its acylation ability toward bacterial penicillin-binding proteins
Abdelhamid Asli +4 more
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Classification of Beta-lactamases and penicillin binding proteins using ligand-centric network models. [PDF]
PLoS ONE, 2015 β-lactamase mediated antibiotic resistance is an important health issue and the discovery of new β-lactam type antibiotics or β-lactamase inhibitors is an area of intense research.
Hakime Öztürk +2 more
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New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria. [PDF]
PLoS ONE, 2011 BACKGROUND: Penicillin-binding proteins (PBPs) are well known and validated targets for antibacterial therapy. The most important clinically used inhibitors of PBPs β-lactams inhibit transpeptidase activity of PBPs by forming a covalent penicilloyl ...
Samo Turk +10 more
doaj +2 more sources
Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins [PDF]
eLife, 2021 Peptidoglycan is an essential component of the bacterial cell envelope that surrounds the cytoplasmic membrane to protect the cell from osmotic lysis. Important antibiotics such as β-lactams and glycopeptides target peptidoglycan biosynthesis.
Víctor M Hernández-Rocamora +5 more
doaj +2 more sources