Results 51 to 60 of about 800,458 (211)
Open Forum Infectious Diseases, 2018 Antibiotic allergies are reported by up to 1 in 4 cancer patients, almost 50% of which are considered low risk and precede the cancer diagnosis. We demonstrate the successful and safe implementation of a pilot oral penicillin challenge program for cancer
J. Trubiano +8 more
semanticscholar +1 more source
Antibiotics, 2020 Conjugation of penicillin G (PenH) with silver(I) ions forms a new CoMeD (conjugate of metal with a drug) with formula [Ag(pen)(CH3OH)]2 (PenAg). PenAg was characterized by a plethora of physical and spectroscopic techniques, which include in the solid ...
Ioannis Ketikidis +6 more
doaj +1 more source
PropertyDAG: Multi-objective Bayesian optimization of partially ordered, mixed-variable properties for biological sequence design [PDF]
arXiv, 2022 Bayesian optimization offers a sample-efficient framework for navigating the exploration-exploitation trade-off in the vast design space of biological sequences. Whereas it is possible to optimize the various properties of interest jointly using a multi-objective acquisition function, such as the expected hypervolume improvement (EHVI), this approach ...
arxiv
The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis.
FEMS Microbiology Reviews, 2008 Penicillin-binding proteins (PBPs) have been scrutinized for over 40 years. Recent structural information on PBPs together with the ongoing long-term biochemical experimental investigations, and results from more recent techniques such as protein ...
E. Sauvage +4 more
semanticscholar +1 more source
Three innovations of next-generation antibiotics: evolvability, specificity, and non-immunogenicity [PDF]
arXiv, 2022 Antimicrobial resistance is a silent pandemic that is being exacerbated by the uncontrolled use of antibiotics. Since the discovery of penicillin, we have been largely dependent on microbe-derived small molecules to treat bacterial infections. However, the golden era of antibiotics is coming to an end as the emergence and spread of antimicrobial ...
arxiv
arXiv, 2023 Serendipity plays an important role in scientific discovery. Indeed, many of the most important breakthroughs, ranging from penicillin to the electric battery, have been made by scientists who were stimulated by a chance exposure to unsought but useful information.
arxiv
Frontiers in Microbiology, 2023 IntroductionFor Streptococcus pneumoniae, β-lactam susceptibility can be predicted from the amino acid sequence of the penicillin-binding proteins PBP1a, PBP2b, and PBP2x.
Helle Brander Eriksen +13 more
doaj +1 more source
Convection shapes the trade-off between antibiotic efficacy and the selection for resistance in spatial gradients [PDF]
, 2017 Since penicillin was discovered about 90 years ago, we have become used to using drugs to eradicate unwanted pathogenic cells. However, using drugs to kill bacteria, viruses or cancer cells has the serious side effect of selecting for mutant types that survive the drug attack.
arxiv +1 more source
Complete Resolution of Nonimmune Hydrops Fetalis Secondary to Maternal Syphilis Infection
American Journal of Perinatology Reports, 2023 Maternal syphilis infection is a common infectious cause of nonimmune hydrops fetalis. Generally, hydrops fetalis is equated with poor prognoses in affected pregnancies.
Andreea Dinicu +3 more
doaj +1 more source
Infection and Drug Resistance, 2022 Asmamaw Nitsuh Woreta,1,2 Habtamu Biazin Kebede,1 Yonas Tilahun,3 Solomon Gebreselassie Teklegiorgis,1 Woldaregay Erku Abegaz1 1Department of Microbiology, Immunology and Parasitology, College of Health Sciences, Addis Ababa University, Addis Ababa ...
Woreta AN +4 more
doaj