Results 21 to 30 of about 251 (118)

The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity [PDF]

Pharmaceuticals
We highlight the particular aspects of the stable gastric pentadecapeptide BPC 157 pleiotropic beneficial activity (not destroyed in human gastric juice, native and stable in human gastric juice, as a cytoprotection mediator holds a response specifically
Predrag Sikiric, Alenka Boban Blagaic, Sanja Strbe, Lidija Beketic Oreskovic, Ivana Oreskovic, Suncana Sikiric, Mario Staresinic, Marko Sever, Antonio Kokot, Ivana Jurjevic, Danijel Matek, Luka Coric, Ivan Krezic, Ante Tvrdeic, Kresimir Luetic, Lovorka Batelja Vuletic, Predrag Pavic, Tomislav Mestrovic, Ivica Sjekavica, Anita Skrtic, Sven Seiwerth   +20 more
doaj   +2 more sources

Stable Gastric Pentadecapeptide BPC 157 as a Therapy and Safety Key: A Special Beneficial Pleiotropic Effect Controlling and Modulating Angiogenesis and the NO-System [PDF]

Pharmaceuticals
Although approached through many concepts, the pleiotropic healing issue, specifically, maintaining/reestablishing tissue integrity, remains a central challenge in pharmacology, particularly when the process is misdirected or not properly controlled ...
Predrag Sikiric, Sven Seiwerth, Anita Skrtic, Mario Staresinic, Sanja Strbe, Antonia Vuksic, Suncana Sikiric, Dinko Bekic, Dragan Soldo, Boris Grizelj, Luka Novosel, Lidija Beketic Oreskovic, Ivana Oreskovic, Mirjana Stupnisek, Alenka Boban Blagaic, Ivan Dobric   +15 more
doaj   +2 more sources

Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157 [PDF]

Biomedicines, 2021
We redefined Robert’s prototypical cytoprotection model, namely the intragastric administration of 96% alcohol in order to generate a general peripheral and central syndrome similar to that which occurs when major central or peripheral veins are occluded
Slaven Gojkovic, Ivan Krezic, Hrvoje Vranes, Helena Zizek, Domagoj Drmic, Lovorka Batelja Vuletic, Marija Milavic, Suncana Sikiric, Irma Stilinovic, Paris Simeon, Mario Knezevic, Toni Kolak, Marijan Tepes, Karol Simonji, Sanja Strbe, Nora Nikolac Gabaj, Ivan Barisic, Emma Grace Oreskovic, Eva Lovric, Antonio Kokot, Anita Skrtic, Alenka Boban Blagaic, Sven Seiwerth, Predrag Sikiric   +23 more
doaj   +2 more sources

Stable Gastric Pentadecapeptide BPC 157, Robert’s Stomach Cytoprotection/Adaptive Cytoprotection/Organoprotection, and Selye’s Stress Coping Response: Progress, Achievements, and the Future [PDF]

Gut and Liver, 2020
We reviewed again the significance of the stable gastric pentadecapeptide BPC 157 as a likely mediator of Robert’s stomach cytoprotection/adaptive cytoprotection and organoprotection and as novel mediator of Selye’s stress coping response to reestablish ...
Predrag Sikiric, Ki-Baik Hahm, Alenka Boban Blagaic, Ante Tvrdeic, Katarina Horvat Pavlov, Andrea Petrovic, Antonio Kokot, Slaven Gojkovic, Ivan Krezic, Domagoj Drmic, Rudolf Rucman, Sven Seiwerth   +11 more
doaj   +2 more sources

Stable Gastric Pentadecapeptide BPC 157 May Counteract Myocardial Infarction Induced by Isoprenaline in Rats [PDF]

Biomedicines, 2022
We revealed that the stable gastric pentadecapeptide BPC 157, a useful peptide therapy against isoprenaline myocardial infarction, as well as against isoprenaline myocardial reinfarction, may follow the counteraction of the recently described occlusion ...
Ivan Barisic, Diana Balenovic, Mario Udovicic, Darija Bardak, Dean Strinic, Josipa Vlainić, Hrvoje Vranes, Ivan Maria Smoday, Ivan Krezic, Marija Milavic, Suncana Sikiric, Sandra Uzun, Gordana Zivanovic Posilovic, Sanja Strbe, Ivan Vukoja, Eva Lovric, Marin Lozic, Marko Sever, Martina Lovric Bencic, Alenka Boban Blagaic, Anita Skrtic, Sven Seiwerth, Predrag Sikiric   +22 more
doaj   +2 more sources

Tracheocutaneous Fistula Resolved by Pentadecapeptide BPC 157 Therapy Through the NO-System—Triple NO-Agent Approach in Rats [PDF]

Pharmaceuticals
Background/Objectives: This 7-day rat tracheocutaneous fistula study considered the not-studied issues of tracheocutaneous fistula course, wound healing, and fistula in the NO-system relations.
Goran Madzarac, Tomislav Becejac, Toni Penovic, Dominik Drazenovic, Lucija Kralj, Marta Popović Dolic, Suncana Sikiric, Lidija Beketic Oreskovic, Ivana Oreskovic, Sanja Strbe, Ana Maria Tubikanec, Mihovil Penavic, Hrvoje Vranes, Ivan Krezic, Mario Kordic, Antun Koprivanac, Tinka Vidovic, Josipa Vlainic, Dinko Stancic Rokotov, Alenka Boban Blagaic, Sven Seiwerth, Anita Skrtic, Predrag Sikiric   +22 more
doaj   +2 more sources

Tendon, Ligament, and Muscle Injury, Osteotendinous, Myotendinous, and Muscle-to-Bone Junction Therapy Perspectives with Growth Factors and Stable Gastric Pentadecapeptide BPC 157—A Review [PDF]

Pharmaceuticals
As a novel theoretical and practical advantage, preclinical to clinical evidence, this systematic review of PRP, growth factors, and stable gastric pentadecapeptide BPC 157 efficacy in complex musculoskeletal and junctional injuries emphasizes the ...
Danijel Matek, Irena Matek, Mladen Japjec, Mirta Matek, Jakov Prenc, Borna Staresinic, Eva Staresinic, Andreja Prtoric, Suncana Sikiric, Lidija Beketic Oreskovic, Ivana Oreskovic, Sanja Strbe, Mario Kordic, Ante Tvrdeic, Sven Seiwerth, Predrag Sikiric, Alenka Boban Blagaic, Anita Skrtic, Ivan Bojanic, Ivan Dobric, Mario Staresinic   +20 more
doaj   +2 more sources

Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats [PDF]

Journal of Orthopaedic Surgery and Research, 2019
Background We focused on the therapeutic effects of the stable gastric pentadecapeptide BPC 157 in spinal cord injury using a rat model. BPC 157, of which the LD1 has not been achieved, has been implemented as an anti-ulcer peptide in inflammatory bowel ...
Darko Perovic, Danijela Kolenc, Vide Bilic, Nenad Somun, Domagoj Drmic, Esmat Elabjer, Gojko Buljat, Sven Seiwerth, Predrag Sikiric   +8 more
doaj   +2 more sources

Pentadecapeptide BPC 157 Shortens Duration of Tetracaine- and Oxybuprocaine-Induced Corneal Anesthesia in Rats [PDF]

Acta Clinica Croatica, 2020
We focused on the relationship of 0.5% tetracaine- and 0.4% oxybuprocaine-induced corneal anesthesia in rats, and pentadecapeptide BPC 157 (0.4 μg/eye), along with nitric oxide synthase (NOS) inhibitor N(gamma)-nitro-L-arginine methyl ester (L-NAME) (0.1
Ivan Mirković, Tamara Kralj, Marin Lozić, Vasilije Stambolija, Josip Kovačević, Luka Vrdoljak, Mirna Zlatar, Kristina Milanović, Domagoj Drmić, Jurica Predović, Sanja Masnec, Matija Jurjević, Mladen Bušić, Sven Seiwerth, Antonio Kokot, Predrag Sikirić   +15 more
doaj   +2 more sources

Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC 157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortal Hypotension [PDF]

Biomedicines, 2021
Gastric pentadecapeptide BPC 157 therapy counteracts multiple organ dysfunction syndrome in rats, which have permanent occlusion of the superior mesenteric artery close to the abdominal aorta.
Mario Knezevic, Slaven Gojkovic, Ivan Krezic, Helena Zizek, Dominik Malekinusic, Borna Vrdoljak, Hrvoje Vranes, Tamara Knezevic, Ivan Barisic, Katarina Horvat Pavlov, Domagoj Drmic, Miro Staroveski, Antonija Djuzel, Zoran Rajkovic, Toni Kolak, Ivica Kocman, Eva Lovric, Marija Milavic, Suncana Sikiric, Ante Tvrdeic, Leonardo Patrlj, Sanja Strbe, Antonio Kokot, Alenka Boban Blagaic, Anita Skrtic, Sven Seiwerth, Predrag Sikiric   +26 more
doaj   +2 more sources