Results 41 to 50 of about 258,688 (126)

Stable Gastric Pentadecapeptide BPC 157 and Intestinal Anastomoses Therapy in Rats—A Review [PDF]

Pharmaceuticals
Fran Rasic, Predrag Sikiric, Anita Skrtic   +2 more
exaly   +2 more sources

Antinociceptive Effect of BPC-157 in the Formalin-induced Pain Model [PDF]

Kosin Medical Journal, 2021
Objectives Body protective compound-157 (BPC-157) is a stable gastric pentadecapeptide that has been effective in trials aiming to increase wound healing capabilities and decrease inflammatory cell influx, including studies on the healing of muscles and ...
Sang Yoong Park, So Ron Choi, Jeong Ho Kim, Seung Cheol Lee, Seong Yeop Jeong, Joon Ho Jeong, Tae Young Lee   +6 more
doaj   +1 more source

Stable gastric pentadecapeptide BPC 157

Journal of physiology and pharmacology, 2009
Considering peptidergic drugs, many cytokines, enzymes, clotting factors registered for the use as therapeutic agents in specific conditions, they are mainly given by injection, only occasionally by other routes. Also, to ascertain delivery and activity, they use different carriers, peptide+carrier complex may provide significant methodology/activity ...
Sikirić, Predrag, Seiwerth, Sven, Ručman, Rudolf, Turković, Branko   +3 more
  +7 more sources

Pentadecapeptide BPC 157, in Clinical Trials as a Therapy for Inflammatory Bowel Disease (PL14736), Is Effective in the Healing of Colocutaneous Fistulas in Rats: Role of the Nitric Oxide-System

Journal of Pharmacological Sciences, 2008
We focused on the therapeutic effect of the stable gastric pentadecapeptide BPC 157 and how its action is related to nitric oxide (NO) in persistent colocutaneous fistula in rats (at 5 cm from anus, colon defect of 5 mm, skin defect of 5 mm); this ...
Robert Klicek, Marko Sever, Bozo Radic, Domagoj Drmic, Ivan Kocman, Ivan Zoricic, Tihomir Vuksic, Mihovil Ivica, Ivan Barisic, Spomenko Ilic, Lidija Berkopic, Hrvoje Vrcic, Luka Brcic, Alenka Boban Blagaic, Marijana Coric, Iva Brcic, Dinko Stancic Rokotov, Tomislav Anic, Sven Seiwerth, Predrag Sikiric   +19 more
doaj   +1 more source

Pentadecapeptide BPC 157 Reduces Bleeding and Thrombocytopenia after Amputation in Rats Treated with Heparin, Warfarin, L-NAME and L-Arginine. [PDF]

PLoS ONE, 2015
BPC 157 is a stable gastric pentadecapeptide recently implicated with a role in hemostasis. While NO is largely implicated in hemostatic mechanisms, in tail-amputation-models under heparin- and warfarin-administration, both the NO-synthase (NOS)-blocker,
Mirjana Stupnisek, Antonio Kokot, Domagoj Drmic, Masa Hrelec Patrlj, Anita Zenko Sever, Danijela Kolenc, Bozo Radic, Jelena Suran, Davor Bojic, Aleksandar Vcev, Sven Seiwerth, Predrag Sikiric   +11 more
doaj   +1 more source

Perforating corneal injury in rat and pentadecapeptide BPC 157

Experimental Eye Research, 2015
Based on its healing effects in various tissues, we hypothesized that the stable gastric pentadecapeptide BPC 157 heals corneal ulcerations in rats and effects corneal transparency. We made a penetrant linear 2-mm incision in the paralimbal region of the left cornea at the 5 o'clock position with a 20-gauge MVR incision knife at 45° under an operating ...
Sanja, Masnec, Antonio, Kokot, Mirna, Zlatar, Miro, Kalauz, Kristian, Kunjko, Bozo, Radic, Robert, Klicek, Domagoj, Drmic, Ratimir, Lazic, Luka, Brcic, Radivoje, Radic, Renata, Ivekovic, Sven, Seiwerth, Predrag, Sikiric   +13 more
openaire   +3 more sources

Pentadecapeptide BPC 157 and rat osteoarthritis

The FASEB Journal, 2013
Rat osteoarthritis (transected anterior cruciate and medial collateral ligament, medial meniscectomy) exhibited large cartilage destruction, still preserved bone (4 weeks), proximal tibia (cartilage and bone) totally destructed (8 and 12 weeks), and severely impaired knee function.
Predrag Sikiric, Zoran Krstonijevic, Marko Sever, Nermin Lojo, Domagoj Drmic, Anita Zenko, Luka Brcic, Ivan Zoricic, Zarko Rasic, Rudolf Rucman, Sven Seiwerth   +10 more
openaire   +1 more source

Potential role of peripheral and central vascular failure in neuroleptic, amphetamine and domperidone pharmacodynamics and toxicolog

Liječnički vjesnik, 2023
Vascular failure is a pathological entity that seems to be antecedent to various pathological processes. This investigation theorized that vascular failure-related phenomena would be apparent in early phases after the application of neuroleptics ...
Ivan Maria Smoday, Katarina Oroz, Luka Ćorić   +2 more
doaj   +1 more source

Intragastric Application of Aspirin, Clopidogrel, Cilostazol, and BPC 157 in Rats: Platelet Aggregation and Blood Clot

Oxidative Medicine and Cellular Longevity, Volume 2019, Issue 1, 2019., 2019
We suggest that the stable gastric pentadecapeptide BPC 157 may rescue thrombocyte function. We focused on the antithrombotic agent aspirin, clopidogrel, and cilostazol application in rats; arachidonic acid, ADP, collagen, and arachidonic acid/PGE1 platelet aggregation (aggregometry) and blood clot viscoelastic properties (thromboelastometry); and the ...
Sanja Konosic, Mate Petricevic, Visnja Ivancan, Lucija Konosic, Eleonora Goluza, Branimir Krtalic, Domagoj Drmic, Mirjana Stupnisek, Sven Seiwerth, Predrag Sikiric, Aleksandar Kibel   +10 more
wiley   +1 more source

BPC 157, L-NAME, L-Arginine, NO-Relation, in the Suited Rat Ketamine Models Resembling “Negative-Like” Symptoms of Schizophrenia

Biomedicines, 2022
We attempted throughout the NO-system to achieve the particular counteraction of the ketamine-induced resembling “negative-like” schizophrenia symptoms in rats using pentadecapeptide BPC 157, and NO-agents, NG-nitro-L-arginine methylester (L-NAME), and ...
Andrea Zemba Cilic, Mladen Zemba, Matija Cilic, Sanja Strbe, Spomenko Ilic, Jaksa Vukojevic, Zoran Zoricic, Igor Filipcic, Antonio Kokot, Ivan Maria Smoday, Iva Rukavina, Alenka Boban Blagaic, Ante Tvrdeic, Bozidar Duplancic, Vasilije Stambolija, Darko Marcinko, Anita Skrtic, Sven Seiwerth, Predrag Sikiric   +18 more
doaj   +1 more source