Results 41 to 50 of about 251 (118)

Pentadecapeptide BPC 157 and rat osteoarthritis

The FASEB Journal, 2013
Rat osteoarthritis (transected anterior cruciate and medial collateral ligament, medial meniscectomy) exhibited large cartilage destruction, still preserved bone (4 weeks), proximal tibia (cartilage and bone) totally destructed (8 and 12 weeks), and severely impaired knee function.
Predrag Sikiric, Zoran Krstonijevic, Marko Sever, Nermin Lojo, Domagoj Drmic, Anita Zenko, Luka Brcic, Ivan Zoricic, Zarko Rasic, Rudolf Rucman, Sven Seiwerth   +10 more
openaire   +1 more source

Perforating corneal injury in rat and pentadecapeptide BPC 157

Experimental Eye Research, 2015
Based on its healing effects in various tissues, we hypothesized that the stable gastric pentadecapeptide BPC 157 heals corneal ulcerations in rats and effects corneal transparency. We made a penetrant linear 2-mm incision in the paralimbal region of the left cornea at the 5 o'clock position with a 20-gauge MVR incision knife at 45° under an operating ...
Sanja, Masnec, Antonio, Kokot, Mirna, Zlatar, Miro, Kalauz, Kristian, Kunjko, Bozo, Radic, Robert, Klicek, Domagoj, Drmic, Ratimir, Lazic, Luka, Brcic, Radivoje, Radic, Renata, Ivekovic, Sven, Seiwerth, Predrag, Sikiric   +13 more
openaire   +3 more sources

Pentadecapeptide BPC 157 Reduces Bleeding and Thrombocytopenia after Amputation in Rats Treated with Heparin, Warfarin, L-NAME and L-Arginine. [PDF]

PLoS ONE, 2015
BPC 157 is a stable gastric pentadecapeptide recently implicated with a role in hemostasis. While NO is largely implicated in hemostatic mechanisms, in tail-amputation-models under heparin- and warfarin-administration, both the NO-synthase (NOS)-blocker,
Mirjana Stupnisek, Antonio Kokot, Domagoj Drmic, Masa Hrelec Patrlj, Anita Zenko Sever, Danijela Kolenc, Bozo Radic, Jelena Suran, Davor Bojic, Aleksandar Vcev, Sven Seiwerth, Predrag Sikiric   +11 more
doaj   +1 more source

Potential role of peripheral and central vascular failure in neuroleptic, amphetamine and domperidone pharmacodynamics and toxicolog

Liječnički vjesnik, 2023
Vascular failure is a pathological entity that seems to be antecedent to various pathological processes. This investigation theorized that vascular failure-related phenomena would be apparent in early phases after the application of neuroleptics ...
Ivan Maria Smoday, Katarina Oroz, Luka Ćorić   +2 more
doaj   +1 more source

BPC 157, L-NAME, L-Arginine, NO-Relation, in the Suited Rat Ketamine Models Resembling “Negative-Like” Symptoms of Schizophrenia

Biomedicines, 2022
We attempted throughout the NO-system to achieve the particular counteraction of the ketamine-induced resembling “negative-like” schizophrenia symptoms in rats using pentadecapeptide BPC 157, and NO-agents, NG-nitro-L-arginine methylester (L-NAME), and ...
Andrea Zemba Cilic, Mladen Zemba, Matija Cilic, Sanja Strbe, Spomenko Ilic, Jaksa Vukojevic, Zoran Zoricic, Igor Filipcic, Antonio Kokot, Ivan Maria Smoday, Iva Rukavina, Alenka Boban Blagaic, Ante Tvrdeic, Bozidar Duplancic, Vasilije Stambolija, Darko Marcinko, Anita Skrtic, Sven Seiwerth, Predrag Sikiric   +18 more
doaj   +1 more source

Intragastric Application of Aspirin, Clopidogrel, Cilostazol, and BPC 157 in Rats: Platelet Aggregation and Blood Clot

Oxidative Medicine and Cellular Longevity, Volume 2019, Issue 1, 2019., 2019
We suggest that the stable gastric pentadecapeptide BPC 157 may rescue thrombocyte function. We focused on the antithrombotic agent aspirin, clopidogrel, and cilostazol application in rats; arachidonic acid, ADP, collagen, and arachidonic acid/PGE1 platelet aggregation (aggregometry) and blood clot viscoelastic properties (thromboelastometry); and the ...
Sanja Konosic, Mate Petricevic, Visnja Ivancan, Lucija Konosic, Eleonora Goluza, Branimir Krtalic, Domagoj Drmic, Mirjana Stupnisek, Sven Seiwerth, Predrag Sikiric, Aleksandar Kibel   +10 more
wiley   +1 more source

Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts

Molecules, 2014
BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies.
Chung-Hsun Chang, Wen-Chung Tsai, Ya-Hui Hsu, Jong-Hwei Su Pang   +3 more
doaj   +1 more source

BPC 157 Therapy and the Permanent Occlusion of the Superior Sagittal Sinus in Rat: Vascular Recruitment

Biomedicines, 2021
We show the complex syndrome of the occluded superior sagittal sinus, brain swelling and lesions and multiple peripheral organs lesions in rat. Recovery goes centrally and peripherally, with the stable gastric pentadecapeptide BPC 157, which alleviated ...
Slaven Gojkovic, Ivan Krezic, Hrvoje Vranes, Helena Zizek, Domagoj Drmic, Katarina Horvat Pavlov, Andrea Petrovic, Lovorka Batelja Vuletic, Marija Milavic, Suncana Sikiric, Irma Stilinovic, Mariam Samara, Mario Knezevic, Ivan Barisic, Ivica Sjekavica, Eva Lovric, Anita Skrtic, Sven Seiwerth, Predrag Sikiric   +18 more
doaj   +1 more source

Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats

World Journal of Gastroenterology, 2004
To investigate the protective effects of gastric pentadecapeptide BPC 157 on acute and chronic gastric ulcers in rats and to compare the results in therapy of human gastric ulcers by different administration methods.Gastric pentadecapeptide BPC 157 was administered (initial single or continuous administration) into rats either intragastrically or ...
Xiao-Chang, Xue, Yong-Jie, Wu, Ming-Tang, Gao, Wen-Guang, Li, Ning, Zhao, Zeng-Lu, Wang, Chun-Jie, Bao, Zhen, Yan, Ying-Qi, Zhang   +8 more
openaire   +2 more sources

Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat [PDF]

Journal of Orthopaedic Research, 2010
AbstractWe improved medial collateral ligament (MCL) healing throughout 90 days after surgical transection. We introduced intraperitoneal, per‐oral (in drinking water) and topical (thin cream layer) peptide therapy always given alone, without a carrier.
Cerovečki, Tomislav, Bojanić, Ivan, Brčić, Luka, Radić, Božo, Vukoja, Ivan, Seiwerth, Sven, Sikirić, Predrag   +6 more
openaire   +2 more sources