Results 51 to 60 of about 251 (118)

PENTADECAPEPTIDE BPC 157: PANACEA OR OVERHYPED PEPTIDE?

European Journal of Physical Education and Sport Science
<p>Interest in Pentadecapeptide BPC 157, an oligopeptide originally derived from human gastric juice, has grown substantially among members of the fitness community in the past few years due to its wide range of purported and previously reported effects on improving health and enhancing performance.
Joseph A. Giandonato, Victor Tringali
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Multifunctionality and Possible Medical Application of the BPC 157 Peptide—Literature and Patent Review

Pharmaceuticals
BPC 157, known as the “Body Protection Compound”, is a pentadecapeptide isolated from human gastric juice that demonstrated its pleiotropic beneficial effects in various preclinical models mimicking medical conditions, such as tissue injury, inflammatory
Michalina Józwiak, Marta Bauer, Wojciech Kamysz, Patrycja Kleczkowska   +3 more
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Gastric pentadecapeptide BPC 157 effective against serotonin syndrome in rats [PDF]

European Journal of Pharmacology, 2005
Serotonin syndrome commonly follows irreversible monoamine oxidase (MAO)-inhibition and subsequent serotonin (5-HT) substrate (in rats with fore paw treading, hind limbs abduction, wet dog shake, hypothermia followed by hyperthermia). A stable gastric pentadecapeptide BPC 157 with very safe profile (inflammatory bowel disease clinical phase II, PL-10 ...
Boban Blagaić, Alenka, Blagaić, Vladimir, Mirt, Mirela, Jelovac, Nikola, Dodig, Goran, Ručman, Rudolf, Petek, Marijan, Turković, Branko, Anić, Tomislav, Dubovećak, Miroslav, Starešinić, Mario, Seiwerth, Sven, Sikirić, Predrag   +12 more
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Spinal Instability in Rats Counteracted by Pentadecapeptide BPC 157

The FASEB Journal, 2019
To induce spinal instability, we focused on bilateral facetectomy in rats and possible therapeutic benefit with the stable gastric pentadecapeptide BPC 157 given in the drinking water. Recently, using a well‐designed rat model (L2‐L3 compression), we demonstrated that the stable gastric pentadecapeptide BPC 157 improved the spinal cord injury (FASEB J ...
Dokuzovic, Stjepan, Bebek, Igor, Perovic, Darko, Bilic, Vide, Corluka, Stipe, Krezic, Ivan, Durasin, Tajana, Drmic, Domagoj, Seiwerth, Sven, Sikiric, Predrag   +9 more
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Stable Pentadecapeptide BPC 157 and Vesicovaginal Fistulas in Rats

The FASEB Journal, 2018
Aim Frequently, large vesicovaginal fistulas need operation treatment. Stable gastric pentadecapeptide BPC 157, tested in clinical trials for ulcerative colitis therapy and now multiple sclerosis (Curr Pharm Des. 2017;23(27):4012–4028; Curr Pharm Des. 2014;20(7):1126–35; Curr Pharm Des.
Rasic, Domagoj, Sever, Marko, Sever, Anita Zenko, Pavlov, Katarina Horvat, Baric, Marko, Drmic, Domagoj, Blagaic, Alenka Boban, Seiwerth, Sven, Sikiric, Predrag   +8 more
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Pentadecapeptide BPC 157 Therapy in Rats with Cysteamine Induced‐Terminal Ileitis

The FASEB Journal, 2020
Aim We introduce pentadecapeptide BPC 157 therapy in rats with cysteamine induced‐terminal ileitis, 1 h, 1 month, 2 months. We counteracted gross hyperemia, edema, erosion, bleeding, and, microscopically, significant loss of villous architecture, loss and shortening of villae and severe lymphocytic infiltrate ...
Radic, Bozo, Samara, Mariam, Zizek, Helena, Gojkovic, Slaven, Krezic, Ivan, Malekinusic, Dominik, Durasin, Tajana, Drmic, Domagoj, Amic, Fedor, Petrovic, Andrea, Pavlov, Katarina Horvat, Seiwerth, Sven, Sikiric, Predrag   +12 more
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BPC 157 Therapy: Targeting Angiogenesis and Nitric Oxide’s Cytotoxic and Damaging Actions, but Maintaining, Promoting, or Recovering Their Essential Protective Functions. Comment on Józwiak et al. Multifunctionality and Possible Medical Application of the BPC 157 Peptide—Literature and Patent Review. Pharmaceuticals 2025, 18, 185

Pharmaceuticals
The healing issue is a central, not completely understood, problem in pharmacology, approached by many concepts. One of the most well-known is Robert’s and Szabo’s concept of cytoprotection, which holds innate cell (epithelial (Robert), endothelial ...
Predrag Sikiric, Sven Seiwerth, Anita Skrtic, Mario Staresinic, Sanja Strbe, Antonia Vuksic, Suncana Sikiric, Dinko Bekic, Dragan Soldo, Boris Grizelj, Luka Novosel, Lidija Beketic Oreskovic, Ivana Oreskovic, Mirjana Stupnisek, Alenka Boban Blagaic, Ivan Dobric   +15 more
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An Experimental Model of Prolonged Esophagitis With Sphincter Failure in the Rat and the Therapeutic Potential of Gastric Pentadecapeptide BPC 157

Journal of Pharmacological Sciences, 2006
We report a simple novel rat model that combines prolonged esophagitis and parallel sphincters failure. The anti-ulcer gastric pentadecapeptide BPC 157, which was found to be stable in gastric juice, and is being evaluated in inflammatory bowel disease ...
Igor Petrovic, Ivan Dobric, Petar Drvis, Drazen Shejbal, Luka Brcic, Alenka Boban Blagaic, Lovorka Batelja, Neven Kokic, Ante Tonkic, Stjepan Mise, Tomislav Baotic, Mario Staresinic, Bozo Radic, Ana Jakir, Tihomir Vuksic, Tomislav Anic, Sven Seiwerth, Predrag Sikiric   +17 more
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Unilateral Adrenalectomy, and the Stable Pentadecapeptide BPC 157 as Therapy in Rats—A Cytoprotection Approach

Pharmaceuticals
Background. This rat study reveals a new point: the considerable impact of unilateral adrenalectomy, severe vascular and multiorgan failure, occlusion/occlusion-like syndrome, and the stable gastric pentadecapeptide BPC 157 therapy.
Ivan Maria Smoday, Vlasta Vukovic, Katarina Oroz, Hrvoje Vranes, Luka Kalogjera, Ozren Gamulin, Josipa Vlainic, Marija Milavic, Suncana Sikiric, Nora Nikolac Gabaj, Domagoj Marijancevic, Antun Koprivanac, Laura Tomic, Sanja Strbe, Ivan Barisic, Lidija Beketic Oreskovic, Mario Kordic, Ante Tvrdeic, Sven Seiwerth, Predrag Sikiric, Alenka Boban Blagaic, Anita Skrtic   +21 more
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BPC-157 as an Investigational Peptide Therapeutic: Biopharmaceutical Challenges, Formulation Strategies, and Translational Development Barriers

Pharmaceutics
Background/Objectives: BPC-157 (body protection compound 157) is a synthetic pentadecapeptide derived from a gastric protein fragment with reported cytoprotective and regenerative properties across multiple organ systems.
Diana-Maria Mateescu, Dragos-Mihai Gavrilescu, Florin Eugen Constantinescu, Cristian Oancea, Adrian-Cosmin Ilie, Roxana Folescu, Mihaela-Diana Popa, Stela Iurciuc, Camelia-Oana Muresan, Alexandra Enache   +9 more
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