Results 181 to 190 of about 62,692 (265)

Safety, Tolerability, Pharmacokinetics, Food Effect of Ribitol, and Its Effect on QTcF in Healthy Adults: First‐in‐Human, Randomized, Double‐Blind (Sponsor Unblinded), Placebo‐Controlled Studies

Clinical Pharmacology in Drug Development, Volume 15, Issue 8, August 2026.
Abstract Limb‐girdle muscle dystrophy Type R9 (LGMDR9), also known as LGMD Type 2I, is a rare genetic disease caused by partial loss of function of fukutin‐related protein (FKRP) enzyme which glycosylates alpha‐dystroglycan, thereby stabilizing myocytes during contraction.
Daniel D. Gretler, Athiwat Hutchaleelaha, Uma Sinha, Kristen Rickert, Doug Sproule   +4 more
wiley   +1 more source

Hepatic metabolites indicate differences during late mid-lactation in Holstein cows with different levels of pasture inclusion. [PDF]

Sci Rep
García-Roche M, Astessiano AL, Talmón D, Mendoza A, Cassina A, Quijano C, Carriquiry M.   +6 more
europepmc   +1 more source

Advancing gambogic acid for translational oncology: Redox–proteostasis collapse, multidrug resistance reversal, nanodelivery and biomarker‐guided development

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Gambogic acid exerts anticancer effects through reactive oxygen species‐mediated apoptosis, suppression of nuclear factor kappa B and phosphatidylinositol‐3‐kinase–protein kinase B signalling, multidrug resistance modulation and tumour microenvironment effects.
Uttam Singh Baghel, Kajal Gurow, Geetanjali Mehara, Priyanka Kriplani, Neelam M. Patel, Abhay Sharma, Deeksha Singh, Atamjit Singh, Suchi Dave, Bhawani Singh, Lashyn N. Kiyekbayeva, William N. Setzer, Javad Sharifi‐Rad, Cheryl Grace Pratiwi Rumahorbo, Daniela Calina   +14 more
wiley   +1 more source

Measurement of glycolysis with heavy water labeling. [PDF]

J Biol Chem
Ziari N, Hellerstein MK.
europepmc   +1 more source

TALDO1 promotes lipid metabolic reprogramming and immunosuppressive microenvironment remodelling in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Deep autoencoder algorithm identified TALDO1 as a key metabolic gene associated with HCC progression. TALDO1 promotes lipid synthesis and accumulation in HCC cells and participates in lipid metabolic reprogramming. TALDO1 is associated with immunosuppressive microenvironment remodelling, and targeting TALDO1 reduces the infiltration of ...
Fenglin Lv, Huaxin Zhou, Jingyan Yang, Jianglei Xu, Fanqing Bi, Yi Zhou, Hao Zhang, Qian Ye, Lin Gao, Bin Jin   +9 more
wiley   +1 more source

Biosynthesis of Ribose-5-Phosphate-Metabolic Regulator of <i>Escherichia coli</i> Viability. [PDF]

Cells
Seregina TA, Shakulov RS, Petrushanko IY, Lobanov KV, Mironov AS.   +4 more
europepmc   +1 more source

The evolving landscape of the Warburg effect in gastric cancer: From molecular mechanisms to targeted therapy

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Hypoxia, oncogenic signaling, transcriptional and epigenetic remodeling, and H. pylori–microbiota interactions drive the Warburg effect in gastric cancer. Enhanced glycolysis and lactate export support biosynthesis, remodel the tumor microenvironment, promote stromal activation and immune suppression, and reveal actionable biomarkers and therapeutic ...
Guanmo Liu, Pan Li, Zizhuo Li, Jie Li, Chenggang Zhang, Yihua Wang, Weiming Kang, Xin Ye   +7 more
wiley   +1 more source

ADA2-deficient cells exhibit increased levels of cell death and metabolic disturbances. [PDF]

Cell Death Discov
Ehlers L, Wouters M, Pillay B, Delafontaine S, Bucciol G, Baggio M, Dzhus M, Hombrouck A, Damerau A, De Somer L, Schrijvers R, Vanderschueren S, Jacquemyn M, Kallinich T, Daelemans D, Ghesquière B, Agostinis P, Moens L, Meyts I.   +18 more
europepmc   +1 more source

Neutrophil‐based immunotherapy: A metabolic lens on mechanisms and therapeutic implications

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
TAN metabolic reprogramming critically contributes to tumour immune evasion. A 4‑Tier TAN‑MetaC classification framework is proposed, along with an overview of translational opportunities and bottlenecks for TAN metabolism‑targeted immunotherapies. Abstract Background Tumor‐associated neutrophils (TANs) serve as pivotal immune modulators in the tumor ...
Wenchao Xu, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +4 more
wiley   +1 more source

Microbial Synergism Couples Root Metabolic Remodeling with Exudation Dynamics in <i>Liquidambar formosana</i>. [PDF]

Microorganisms
Song J, Chen FM, Zhang LQ, Gu W, Liu CY, Liu JW, Fan YQ, Ren JX, Wan X, Wang JH.   +9 more
europepmc   +1 more source