Expanding the substrate spectrum in engineered Pseudomonas taiwanensis for efficient production of 4-coumarate from lignocellulosic sugars. [PDF]
Wynands B +4 more
europepmc +1 more source
The Gut Microbiome and Diet Interact to Dictate Personalized Response to Broccoli Sprout Consumption
The study investigated how diet, the gut microbiome, and their interactions influence the production of different types of sulforaphane metabolites, specifically bioactive (have health benefits) and inert (do not have health benefits). Mediation analysis explored these tripartite relationships.
Alexandra Alexiev +6 more
wiley +1 more source
Chemical Attributes of UK-Grown Tea and Identifying Catechin and Metabolite Dynamics in Green and Black Tea Using Metabolomics and Machine Learning. [PDF]
Lloyd AJ +7 more
europepmc +1 more source
Single‐nucleus multiomic profiling of postmortem brain reveals coordinated immune, metabolic, and epigenomic reprogramming in glia of people with HIV consistent with maladaptive trained immunity sustaining neuroinflammation in HAND. ABSTRACT HIV‐associated neurocognitive disorders (HAND) remain prevalent in people with HIV (PWH) despite effective ...
Siera Martinez +8 more
wiley +1 more source
Plasma and Brain Metabolomics Uncover Modulation of Bile Acid and Pentose Phosphate Pathways by <i>Melissa officinalis</i> in Obese Rat Model. [PDF]
Aberkane FZ +8 more
europepmc +1 more source
HT‐2 toxin triggers chondrocyte damage and matrix metabolism disorders in KBD via suppressing ZIP6. ZIP6 knockdown alleviates these dysfunctions through FoxO, cAMP and TNF pathways, clarifying the molecular mechanism of cartilage injury. ABSTRACT Kashin‐Beck disease (KBD) is a chronic, endemic osteoarticular disorder associated with T‐2 toxin exposure,
Yang Liu +10 more
wiley +1 more source
Higher order synthetic lethals are keys to minimize cancer treatment effects on non-tumor cells. [PDF]
Dehghan Manshadi M +4 more
europepmc +1 more source
ABSTRACT Coronavirus disease 2019 (COVID‐19) survivors frequently experience a wide range of symptoms known as post‐acute sequelae of SARS‐CoV‐2 (PASC) or long COVID. Importantly, complications arising from microvascular dysfunction, blood‐brain barrier (BBB) disruption, and chronic neuroinflammation have been implicated in driving PASC within the ...
Arpan Acharya +7 more
wiley +1 more source
Metabolomic characterization and temporal dynamics of Burkholderia cepacia for polyhydroxyalkanoates production from oleic acid. [PDF]
Alarcón AE +4 more
europepmc +1 more source
Correction: Ruan et al. Comparison of Extraction, Isolation, Purification, Structural Characterization and Immunomodulatory Activity of Polysaccharides from Two Species of <i>Cistanche</i>. <i>Molecules</i> 2025, <i>30</i>, 4754. [PDF]
Ruan J +7 more
europepmc +1 more source

