Abstract Metabolic alterations and immune dysfunction within the gastric tumor microenvironment critically drive gastric cancer (GC) progression and therapeutic resistance. Although single‐cell RNA sequencing (scRNA‐seq) has unveiled cellular heterogeneity in GC, the metabolic landscapes of tumor cells and their interplay with immune components remain ...
Junjun Liu +7 more
wiley +1 more source
Biosynthesis of Ribose-5-Phosphate-Metabolic Regulator of <i>Escherichia coli</i> Viability. [PDF]
Seregina TA +4 more
europepmc +1 more source
Abstract The genus Citrus is characterized by a reticulate evolutionary history with frequent hybridization, making it an intriguing subject for genome evolution investigation. Citrus changshan‐huyou Y. B. Chang (Huyou) is a unique landrace first discovered in Zhejiang Province, China, with premium fruit quality.
Zhanghui Zeng +14 more
wiley +1 more source
Chemical Attributes of UK-Grown Tea and Identifying Catechin and Metabolite Dynamics in Green and Black Tea Using Metabolomics and Machine Learning. [PDF]
Lloyd AJ +7 more
europepmc +1 more source
Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans +8 more
wiley +1 more source
Life cycle assessment for the production of second generation bioethanol from Eucalyptus wood in Chile [PDF]
Aroca, German E +3 more
core
Engineering a Synthetic Formatotrophic Yeast With Enhanced Growth Capacity on Formate
Engineering Yeast for Growth on Formate and Methanol via Serine‐Centered C1 Coupling. By engineering serine metabolism and remodeling the rGly pathway, we rendered yeast growth strictly dependent on formate. This synthetic formatotrophy enables growth on dual‐C1 substrates by channeling formate into the central metabolism via serine deaminases and ...
Shuyuan Guo +11 more
wiley +1 more source
Spatiotemporal metabolic mapping reveals diet-independent remodeling of the postnatal mouse brain. [PDF]
York EM +4 more
europepmc +1 more source
GLP‐1 agonists and the gut microbiome: A bidirectional relationship
Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research.
Srinivas Kamath +2 more
wiley +1 more source
Integrating blood biochemistry and plasma metabolomics to define age-related metabolic biomarkers in Alope village chickens. [PDF]
Mujnisa A +8 more
europepmc +1 more source

