ABSTRACT Rett syndrome is a neurodevelopmental disorder caused by an X‐linked mutation of the MeCP2 gene. Individuals with Rett syndrome, as well as rodent models of this disorder, demonstrate abnormal cortical responses to sound, which impair auditory discrimination ability.
Isabella K. Myers +6 more
wiley +1 more source
Comparative transcriptome analyses and CRISPR/Cas9-mediated functional study of Tfsdh1 reveal insights into the interaction between Tremella fuciformis and Annulohypoxylon stygium. [PDF]
Wang Y, Xu D, Hao M, Ma A.
europepmc +1 more source
Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang +7 more
wiley +1 more source
Liposomal formulation of <i>Fagonia arabica</i> L. enhances antithrombotic efficacy: phytochemical, pharmacological, and computational investigations. [PDF]
Badawy SA +5 more
europepmc +1 more source
Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang +14 more
wiley +1 more source
Dietary Supplementation of L-Carnosine Attenuates High Starch-Induced Disorders of Carbohydrate and Lipid Metabolisms in Zebrafish. [PDF]
Luo Y, Long Y, Lu X, Cui Z.
europepmc +1 more source
On why cancer cells require a great amount of glucose
Abstract The traditional thinking has been that cancer cells require a great amount of glucose to support their rapid growth, but the reality may be different. We have previously demonstrated that all cancer cells in The Cancer Genome Atlas harbor persistent Fenton reactions in their cytosol, which generate OH− ${\text{OH}}^{-}$ and ultimately kill the
Xuechen Mu +6 more
wiley +1 more source
ADA2-deficient cells exhibit increased levels of cell death and metabolic disturbances. [PDF]
Ehlers L +18 more
europepmc +1 more source
PENTOSE METABOLISM IN WHEAT SEEDLINGS
V, GINSBURG, W Z, HASSID
openaire +2 more sources

