Dipeptidyl Peptidase-4 Inhibitors Associated with Lower Psoriatic Disease Risk in Type 2 Diabetes: A 13-Year Nationwide Cohort Study with Mechanistic Validation [PDF]
Acta Dermato-VenereologicaPsoriatic disease, encompassing psoriasis and -psoriatic arthritis, is a chronic inflammatory condition with bidirectional associations with type 2 diabetes mellitus.
Chih-Tsung Hung +5 more
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Contribution of UbrA, a ubiquitin ligase essential for Arg/N-degron pathway, to peptidase gene expression in Aspergillus oryzae [PDF]
Applied and Environmental MicrobiologyThe degradation of intracellular proteins by N-degron pathways depends on their N-terminal amino acids. In budding yeast, the Arg/N-degron pathway controls the expression of dipeptide/tripeptide transporter gene by degrading a transcriptional repressor ...
Waka Muromachi +4 more
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Enteropathy with impaired membrane digestion and the prospects for cytoprotective therapy
Терапевтический архив, 2021 The article describes enteropathy with impaired membrane digestion (EIMD) as a new nosological form. The main clinical manifestation of EIMD is the poor tolerance of food products, in particular carbohydrates and a decrease in the activity of membrane ...
A. I. Parfenov +6 more
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Pathogenicity and virulence of Streptococcus pneumoniae: Cutting to the chase on proteases
Virulence, 2021 Bacterial proteases and peptidases are integral to cell physiology and stability, and their necessity in Streptococcus pneumoniae is no exception. Protein cleavage and processing mechanisms within the bacterial cell serve to ensure that the cell lives ...
Mary E. Marquart
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The secreted FoAPY1 peptidase promotes Fusarium oxysporum invasion
Frontiers in Microbiology, 2022 The secretion of peptidases from several pathogens has been reported, but the biological function of these proteins in plant-pathogen interactions is poorly understood. Fusarium oxysporum, a soil-borne plant pathogenic fungus that causes Fusarium wilt in
Hengwei Qian +4 more
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Dipeptidyl Peptidase IV as a Muscle Myokine
Frontiers in Physiology, 2020 Dipeptidyl peptidase IV (DPP-IV) is a unique serine protease that exists in a membrane bound state and in a soluble state in most tissues in the body.
Heidi A. Kluess
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Kinetics of casein hydrolysis by peptidase from Bacillus thuringiensis var. israelensis [PDF]
The Ukrainian Biochemical Journal, 2019 The kinetics of enzyme reaction is generally studied using the Michaelis-Menten equation and various methods of its linearization. Each method has its advantages and drawbacks, so their comparison for determining the kinetics of new enzymes action is ...
O. V. Sevastyanov +5 more
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Leader peptide removal in lasso peptide biosynthesis based on penultimate isoleucine residue
Frontiers in Microbiology, 2023 Lasso peptides are ribosomally synthesized peptides that undergo post-translational modifications including leader peptide removal by B (or the segregated B1 and B2) proteins and core peptide macrolactamization by C proteins to form a unique lariat ...
Yuwei Duan +11 more
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Japanese Traditional Miso and Koji Making
Journal of Fungi, 2021 Miso is a traditional Japanese seasoning paste produced by fermenting soybeans using the power of koji mold. A recent Japanese cohort study has shown that increased consumption of fermented soybean products is associated with a reduced risk of death in ...
Ken-Ichi Kusumoto +6 more
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Thimet Oligopeptidase Biochemical and Biological Significances: Past, Present, and Future Directions
Biomolecules, 2020 Thimet oligopeptidase (EC 3.4.24.15; EP24.15, THOP1) is a metallopeptidase ubiquitously distributed in mammalian tissues. Beyond its previously well characterized role in major histocompatibility class I (MHC-I) antigen presentation, the recent ...
Emer S. Ferro +2 more
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