Results 91 to 100 of about 319,110 (303)

Defining the core proteome of the chloroplast envelope membranes [PDF]

, 2013
High-throughput protein localization studies require multiple strategies. Mass spectrometric analysis of defined cellular fractions is one of the complementary approaches to a diverse array of cell biological methods. In recent years, the protein content
Ibrahim, Mohamed, Karas, Michael, Leisegang, Matthias, Mirus, Oliver, Müller, Bernd, Papasotiriou, Dimitrios, Schleiff, Enrico, Schorge, Tobias, Simm, Stefan, Sommer, Maik Sascha   +9 more
core   +2 more sources

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

Diatom Proteomics Reveals Unique Acclimation Strategies to Mitigate Fe Limitation [PDF]

, 2015
Phytoplankton growth rates are limited by the supply of iron (Fe) in approximately one third of the open ocean, with major implications for carbon dioxide sequestration and carbon (C) biogeochemistry.
Boyd, Philip W., Faux, Jessica F., Goodlett, David R., Harvey, H. Rodger, Hippmann, Anna A., Maldonado, Maria T., Nunn, Brook L., Strzepek, Robert F.   +7 more
core   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Natural product diversity of actinobacteria in the Atacama Desert [PDF]

, 2018
Natural Product diversityPeer reviewedPublisher ...
Ebel, Rainer, Jaspars, Marcel, Rateb, Mostafa E.   +2 more
core   +3 more sources

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Circular and Leaderless Bacteriocins: Biosynthesis, Mode of Action, Applications, and Prospects

Frontiers in Microbiology, 2018
Bacteriocins are a huge family of ribosomally synthesized peptides known to exhibit a range of bioactivities, most predominantly antibacterial activities.
Rodney H. Perez, Rodney H. Perez, Takeshi Zendo, Kenji Sonomoto   +3 more
doaj   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Binase deletion mutant with enhanced cytotoxic properties [PDF]

BIO Web of Conferences
Antitumor peptides are a new class of small molecules characterized by high specificity and therapeutic efficacy. One of the strategies for developing peptide-based therapeutic agents is the modification of the physicochemical properties and structural ...
Dudkina Elena, Kosnyrev Alexander, Ilinskaya Olga, Ulyanova Vera   +3 more
doaj   +1 more source

Channel-forming activity of syringopeptin 25 A in mercury-supported phospholipid monolayers and negatively charged bilayers [PDF]

, 2016
Interactions of the cationic lipodepsipeptide syringopeptin 25 A (SP25A) with mercury-supported dioleoylphosphatidylcholine (DOPC), dioleoylphosphatidylserine (DOPS) and dioeleoylphosphatidic acid (DOPA) self-assembled monolayers (SAMs) were investigated
Becucci, Lucia, Fiore, Alberto, Guidelli, Rolando, Scaloni, Andrea, Toppi, Arianna   +4 more
core   +2 more sources