Results 241 to 250 of about 200,892 (306)

Trojan Horses: Conjugating Siderophores and Antibiotics-A New Approach to Treating <i>Pseudomonas aeruginosa</i> Infection. [PDF]

Microorganisms
Xiao W, Ma X, Liu D, Li S, Cheng J, Lin J.   +5 more
europepmc   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

Establishment of Three Different Glycation-Damage Cell Models and Analysis of Their Action Mechanism. [PDF]

Metabolites
Qian X, Cao C, Liu L.
europepmc   +1 more source

Distinct contributions of O-acetylserine sulfhydrylases to cysteine biosynthesis in Pseudomonas aeruginosa. [PDF]

Protein Sci
Massa N, Catalano F, Fruncillo S, Troilo F, Mellini M, Favretto F, Leoni L, Rampioni G, Giuffrè A, di Matteo A, Astegno A.   +10 more
europepmc   +1 more source

Biosynthesis of 14-Membered Cyclopeptide Alkaloids via Nonheme Iron- and 2-Oxoglutarate-Dependent Oxidative Decarboxylation. [PDF]

J Am Chem Soc
Hungerford J, Mydy LS, Wang X, Mendoza-Perez L, Ousley DA, Shafiq K, McDonough KM, Li W, May G, Chigumba DN, Yao S, Kersten RD.   +11 more
europepmc   +1 more source

Repositioning the Leader Peptide in Graspetide Biosynthesis. [PDF]

J Am Chem Soc
Johnson TG, Miller DM, Carson DV, Choi B, Link AJ.   +4 more
europepmc   +1 more source

Advances in Biosynthesis of Peptide Drugs: Technology and Industrialization [PDF]

Biotechnology Journal, 2023
Peptide drugs are developed from endogenous or synthetic peptides with specific biological activities. They have advantages of strong target specificity, high efficacy and low toxicity, thus showing great promise in the treatment of many diseases such as cancer, infections and diabetes. Although an increasing number of peptide drugs have entered market
Jing Wang, Long Chen, Song Qin, Mingyuan Xie, Shi‐Zhong Luo, Wenjun Li   +5 more
openaire   +3 more sources

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Engineered biosynthesis of peptide antibiotics

Biochemical Pharmacology, 1996
In certain bacteria and filamentous fungi, a wide variety of bioactive peptides are produced non-ribosomally on large protein templates, called peptide synthetases. Recently, significant progress has been made towards understanding the modular arrangement of these complex multifunctional enzymes and the mechanisms by which they generate their ...
T, Stachelhaus, A, Schneider, M A, Marahiel   +2 more
openaire   +2 more sources