Results 241 to 250 of about 900,801 (302)

Actinomycin Derivatives: Structural Diversification and Biological Activities. [PDF]

ChemMedChem
Can Ö, Bedir E.
europepmc   +1 more source

Translation as a regulatory hub for secondary metabolism in Streptomyces spp. [PDF]

Essays Biochem
Brave A, Straight PD.
europepmc   +1 more source

Reprogramming the enduracidin NRPS assembly line via thioesterase domain relocation. [PDF]

Synth Syst Biotechnol
Sun Y, Tu G, Sun X, Zhang H, Wang H, Liu F, Lu F, Zhang H.   +7 more
europepmc   +1 more source

Inverse stable isotopic labeling for natural product characterization and discovery.

Nat Prod Rep
Robes JMD, Puri AW.
europepmc   +1 more source

Advances in Biosynthesis of Peptide Drugs: Technology and Industrialization

Biotechnology Journal, 2023
Peptide drugs are developed from endogenous or synthetic peptides with specific biological activities. They have advantages of strong target specificity, high efficacy and low toxicity, thus showing great promise in the treatment of many diseases such as cancer, infections and diabetes. Although an increasing number of peptide drugs have entered market
Jing Wang, Long Chen, Song Qin, Mingyuan Xie, Shi‐Zhong Luo, Wenjun Li   +5 more
openaire   +3 more sources

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Engineered biosynthesis of peptide antibiotics

Biochemical Pharmacology, 1996
In certain bacteria and filamentous fungi, a wide variety of bioactive peptides are produced non-ribosomally on large protein templates, called peptide synthetases. Recently, significant progress has been made towards understanding the modular arrangement of these complex multifunctional enzymes and the mechanisms by which they generate their ...
T, Stachelhaus, A, Schneider, M A, Marahiel   +2 more
openaire   +2 more sources

On the biosynthesis of peptide ergot alkaloids

Experientia, 1974
Futterung vonl-Valyl-(1-14C)-l-valyl-l-prolin anClaviceps purpurea und Abbau des erhaltenen Ergocornins und Ergokryptins zeigt, dass dieses Tripeptid, ebenso wie andere fruher untersuchte Peptide, sehr wahrscheinlich kein freies Zwischenprodukt in der Biogenese der Mutterkornalkaloide vom Peptidtyp ist.
H G, Floss, M, Tcheng-Lin, H, Kobel, P, Stadler   +3 more
openaire   +2 more sources

Engineering the biosynthesis of fungal nonribosomal peptides

Natural Product Reports, 2023
Fungal nonribosomal peptides (NRPs) and the related polyketide–nonribosomal peptide hybrid products (PK–NRPs) are a prolific source of bioactive compounds, some of which have been developed into essential drugs.
Zhang, Liwen, Wang, Chen, Chen, Kang, Zhong, Weimao, Xu, Yuquan, Molnár, István   +6 more
openaire   +3 more sources

Biosynthesis and distribution of opioid peptides

Journal of Endocrinological Investigation, 1983
Group III opioid peptides are derived from proenkephalin B. The processing of this precursor peptide is still only partly understood and we still do not know how many final products come from proenkephalin B and whether Leu-enkephalin is produced from Group III peptides.
H, Imura, Y, Nakai, K, Nakao, S, Oki, I, Tanaka, H, Jingami, T, Yoshimasa, T, Tsukada, Y, Ikeda, M, Suda, M, Sakamoto   +10 more
openaire   +2 more sources