Results 261 to 270 of about 900,801 (302)

Biosynthesis of antibiotic peptides with isoleucine stereoisomers

Archives of Biochemistry and Biophysics, 1972
Abstract Streptomyces antibioticus normally synthesizes an actinomycin mixture which contains N -methyl- l -valine and d -valine in the antibiotic peptides. Amino acid analyses indicate that trace amounts of isoleucine and, possibly, N -methylalloisoleucine are present also in actinomycin molecules. S.
T, Yajima, M A, Grigg, E, Katz
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Biosynthesis of Cardiac Natriuretic Peptides

2009
Cardiac-derived peptide hormones were identified more than 25 years ago. An astonishing amount of clinical studies have established cardiac natriuretic peptides and their molecular precursors as useful markers of heart disease. In contrast to the clinical applications, the biogenesis of cardiac peptides has only been elucidated during the last decade ...
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The Biosynthesis of Neuropeptides: Peptide alpha-Amidation

Annual Review of Neuroscience, 1992
The prevalence, diversity, and multiplicity of functions of pep tides in the nervous system are well known. However, we are only now approaching the point at which our knowledge about the biosynthesis of neuropeptides can provide us with insights into nervous system function, just as our knowledge of the enzymes involved in the biosynthesis of ...
B A, Eipper, D A, Stoffers, R E, Mains
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The role of ascorbate in the biosynthesis of neuroendocrine peptides

The American Journal of Clinical Nutrition, 1991
The biosynthesis of all alpha-amidated peptides requires the participation of peptidylglycine alpha-amidating monooxygenase (PAM), a bifunctional enzyme dependent on molecular oxygen, ascorbate, and copper. In the AtT-20 corticotrope cell line, reduced concentrations of PAM and ascorbate can make alpha-amidation the rate-limiting step in the production
B A, Eipper, R E, Mains
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Combinatorial Biosynthesis of Non-Ribosomal Peptides

Combinatorial Chemistry & High Throughput Screening, 2003
Non-ribosomal peptide synthetases (NRPS) are modular assembly lines catalysing the synthesis of many small peptides in microbes. Genetic replacements of domains or modules in NRPS encoded by gene clusters in Bacillus sp. with corresponding domains or modules from foreign NRPS have led in several cases to the in vivo synthesis of peptides with predicted
Ullrich, Keller, Florian, Schauwecker
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Biosynthesis of Peptide Antibiotics

Annual Review of Microbiology, 1987
H, Kleinkauf, H, von Döhren
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Combinatorial biosynthesis of polyketides and nonribosomal peptides

Current Opinion in Chemical Biology, 2001
The engineering of polyketide biosynthesis has begun to provide robust targeted libraries for screening against pharmaceutically relevant targets. New technologies that offer methodology for the rapid generation of more structurally diverse libraries have now been demonstrated.
J, Staunton, B, Wilkinson
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Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis

Natural Product Reports, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Florian, Kopp, Mohamed A, Marahiel
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Biosynthesis of Peptide Antibiotics

1981
Elucidation of the biosynthetic mechanisms of gramicidin S (Kleinkauf and Gevers, 1969; Kleinkauf and Koischwitz, 1980; Kurahashi, 1974; Kurahashi et al., 1969; Laland and Zimmer, 1973; Lipmann, 1971; Lipmann et al., 1971; Saito et al., 1970) and tyrocidines (Froyshov et al., 1978; Kurahashi, 1974; Kurahashi et al., 1969; Lipmann, 1971; Lipmann et al.,
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Peptide antibiotic biosynthesis: A new approach

Experientia, 1968
Eine verallgemeinernde biosynthetische Theorie uber die Entstehung vond-Aminosauren in Peptid-Antibiotika wird dargestellt und zur Bildung von makrozyklischen Strukturen aus kleineren Ring-systemen in Beziehung gesetzt.
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