Results 251 to 260 of about 319,110 (303)

Biosynthesis of peptide–nucleobase hybrids in ribosomal peptides

Nature Chemical Biology
The main biopolymers in nature are oligonucleotides and polypeptides. However, naturally occurring peptide-nucleobase hybrids are rare. Here we report the characterization of the founding member of a class of peptide-nucleobase hybrid natural products with a pyrimidone motif from a widely distributed ribosomally synthesized and post-translationally ...
Zeng-Fei Pei, Natalia M. Vior, Lingyang Zhu, Andrew W. Truman, Satish K. Nair   +4 more
openaire   +2 more sources

Combinatorial Biosynthesis of Non-Ribosomal Peptides

Combinatorial Chemistry & High Throughput Screening, 2003
Non-ribosomal peptide synthetases (NRPS) are modular assembly lines catalysing the synthesis of many small peptides in microbes. Genetic replacements of domains or modules in NRPS encoded by gene clusters in Bacillus sp. with corresponding domains or modules from foreign NRPS have led in several cases to the in vivo synthesis of peptides with predicted
Ullrich, Keller, Florian, Schauwecker
openaire   +2 more sources

Nonribosomal biosynthesis of backbone-modified peptides

Nature Chemistry, 2017
Biosynthetic modification of nonribosomal peptide backbones represents a potentially powerful strategy to modulate the structure and properties of an important class of therapeutics. Using a high-throughput assay for catalytic activity, we show here that an L-Phe-specific module of an archetypal nonribosomal peptide synthetase can be reprogrammed to ...
David L. Niquille, Douglas A. Hansen, Takahiro Mori, David Fercher, Hajo Kries, Donald Hilvert   +5 more
openaire   +2 more sources

Biosynthesis and distribution of opioid peptides

Journal of Endocrinological Investigation, 1983
Group III opioid peptides are derived from proenkephalin B. The processing of this precursor peptide is still only partly understood and we still do not know how many final products come from proenkephalin B and whether Leu-enkephalin is produced from Group III peptides.
H, Imura, Y, Nakai, K, Nakao, S, Oki, I, Tanaka, H, Jingami, T, Yoshimasa, T, Tsukada, Y, Ikeda, M, Suda, M, Sakamoto   +10 more
openaire   +2 more sources

Peptide Hormone Biosynthesis — Recent Developments

1985
The biosynthesis of peptide hormones is now recognized to be a highly ordered series of events. These biosynthetic events can frequently be localized to a particular subcellular organelle (Fig.1). Each organelle will be discussed in turn, to emphasize the sequential nature of the maturation process.
openaire   +2 more sources

Biosynthesis of Cardiac Natriuretic Peptides

2009
Cardiac-derived peptide hormones were identified more than 25 years ago. An astonishing amount of clinical studies have established cardiac natriuretic peptides and their molecular precursors as useful markers of heart disease. In contrast to the clinical applications, the biogenesis of cardiac peptides has only been elucidated during the last decade ...
openaire   +3 more sources

Biosynthesis of Neuronal Peptides

1977
The general acceptance of the idea that peptides represent a new class of intercellular messengers in the nervous system (i.e., neurotransmitters and neuromodulators) naturally raises the question whether the biosynthetic mechanisms for peptides in “peptidergic” neurons (i.e., neurons that synthesize peptides for release as intercellular messengers ...
Harold Gainer, Y. Peng Loh, Yosef Sarne
openaire   +1 more source

In Situ Biosynthesis of Peptide Arrays

2009
Polypeptide and protein arrays enable high-throughput screening capabilities for studying molecular interactions and profiling of biomarkers, and provide a powerful functional screening tool for peptidomics. To overcome the limitations of conventional arraying methods, we have exploited cell-free systems for generating arrays of polypeptides by direct ...
Mingyue, He, Oda, Stoevesandt
openaire   +2 more sources

Biosynthesis of antibiotic peptides with isoleucine stereoisomers

Archives of Biochemistry and Biophysics, 1972
Abstract Streptomyces antibioticus normally synthesizes an actinomycin mixture which contains N -methyl- l -valine and d -valine in the antibiotic peptides. Amino acid analyses indicate that trace amounts of isoleucine and, possibly, N -methylalloisoleucine are present also in actinomycin molecules. S.
T, Yajima, M A, Grigg, E, Katz
openaire   +2 more sources

On the biosynthesis of peptide ergot alkaloids

Experientia, 1974
Futterung vonl-Valyl-(1-14C)-l-valyl-l-prolin anClaviceps purpurea und Abbau des erhaltenen Ergocornins und Ergokryptins zeigt, dass dieses Tripeptid, ebenso wie andere fruher untersuchte Peptide, sehr wahrscheinlich kein freies Zwischenprodukt in der Biogenese der Mutterkornalkaloide vom Peptidtyp ist.
H G, Floss, M, Tcheng-Lin, H, Kobel, P, Stadler   +3 more
openaire   +2 more sources