Results 1 to 10 of about 935,022 (285)
Solubility-Aware Protein Binding Peptide Design Using AlphaFold [PDF]
Biomedicines, 2022 New protein–protein interactions (PPIs) are identified, but PPIs have different physicochemical properties compared with conventional targets, making it difficult to use small molecules.
Takatsugu Kosugi, Masahito Ohue
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Deep Learning for Novel Antimicrobial Peptide Design [PDF]
Biomolecules, 2021 Antimicrobial resistance is an increasing issue in healthcare as the overuse of antibacterial agents rises during the COVID-19 pandemic. The need for new antibiotics is high, while the arsenal of available agents is decreasing, especially for the ...
Christina Wang, Sam Garlick, Mire Zloh
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Inhibition of Viral Membrane Fusion by Peptides and Approaches to Peptide Design [PDF]
Pathogens, 2021 Fusion of lipid-enveloped viruses with the cellular plasma membrane or the endosome membrane is mediated by viral envelope proteins that undergo large conformational changes following binding to receptors.
Nejat Düzgüneş +2 more
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Dynamic Visualization of Computer-Aided Peptide Design for Cancer Therapeutics [PDF]
Drug Design, Development and TherapyDan Hou,1– 3,* Haobin Zhou,1,2,* Yuting Tang,1,2 Ziyuan Liu,1,2 Lin Su,1,2 Junkai Guo,1,2 Janak Lal Pathak,1,2 Lihong Wu1,2 1Department of Basic Oral Medicine, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral ...
Hou D +7 more
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Bioinformatic Analysis of 1000 Amphibian Antimicrobial Peptides Uncovers Multiple Length-Dependent Correlations for Peptide Design and Prediction [PDF]
Antibiotics, 2020 Amphibians are widely distributed on different continents, except for the polar regions. They are important sources for the isolation, purification and characterization of natural compounds, including peptides with various functions.
Guangshun Wang
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mAbs, 2023 Prolactin (PRL) has recently been demonstrated to elicit female-selective nociceptor sensitization and increase pain-like behaviors in female animals.
Stephanie Maciuba +13 more
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Recent Progress on Nanocarriers for Topical-Mediated RNAi Strategies for Crop Protection—A Review
Molecules, 2023 To fulfil the growing needs of the global population, sustainability in food production must be ensured. Insect pests and pathogens are primarily responsible for one-third of food losses and harmful synthetic pesticides have been applied to protect crops
Nurzatil Sharleeza Mat Jalaluddin +3 more
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Molecules, 2022 Data from the World Health Organisation show that the global incidence of dengue infection has risen drastically, with an estimated 400 million cases of dengue infection occurring annually.
Norburhanuddin Johari Zaidi +5 more
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Veterinary Research, 2022 Pseudorabies virus (PRV) variant infections have caused a substantial economic impact on swine production in the absence of new powerful candidate vaccines.
Ling Li +12 more
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Computational Ways to Enhance Protein Inhibitor Design
Frontiers in Molecular Biosciences, 2021 Two new computational approaches are described to aid in the design of new peptide-based drugs by evaluating ensembles of protein structures from their dynamics and through the assessing of structures using empirical contact potential.
Robert L. Jernigan +6 more
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