Results 21 to 30 of about 935,022 (285)
Assessing cellular response to functionalized α-helical peptide hydrogels [PDF]
, 2014 α-Helical peptide hydrogels are decorated with a cell-binding peptide motif (RGDS), which is shown to promote adhesion, proliferation, and differentiation of PC12 cells. Gel structure and integrity are maintained after functionalization.
Abelardo, Edgardo +7 more
core +4 more sources
Applied Sciences, 2023 Collagen is fundamental to a vast diversity of health functions and potential therapeutics. Short peptides targeting collagen are attractive for designing modular systems for site-specific delivery of bioactive agents. Characterization of peptide–protein
Kyle Boone +4 more
doaj +1 more source
CHIMIA, 2013 Computer algorithms help in the identification and optimization of peptides with desired structure and function. We provide an overview of the current focus of our research group in this field, highlighting innovative methods for peptide representation and de novo peptide generation.
Schneider Gisbert +6 more
openaire +4 more sources
Ugi multicomponent reaction to prepare peptide–peptoid hybrid structures with diverse chemical functionalities [PDF]
, 2018 Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi ...
Azevedo, Helena S. +12 more
core +1 more source
Design of amyloidogenic peptide traps
Nature Chemical Biology, 2023 AbstractSegments of proteins with β-strand propensity can self associate to form amyloid fibrils associated with many diseases. These regions often adopt alternative structures in their folded states, or are intrinsically disordered in solution, making it difficult to generate binders or inhibitors with existing strategies.
Danny D. Sahtoe +16 more
openaire +4 more sources
Frontiers in Pharmacology, 2022 MHC class I antigen E (HLA-E), a ligand for the inhibitory NKG2A/CD94 receptor of the immune system, is responsible for evading the immune surveillance in several settings, including senescent cell accumulation and tumor persistence.
Eva Prašnikar +4 more
doaj +1 more source
Dependence of Self-Assembled Peptide Hydrogel Network Structure on Local Fibril Nanostructure [PDF]
, 2009 Physically cross-linked, fibrillar hydrogel networks are formed by the self-assembly of β-hairpin peptide molecules with varying degrees of strand asymmetry.
Hammouda, Boualem +4 more
core +2 more sources
Tzu Chi Medical Journal, 2020 Objective: Human interleukin-10 (IL-10) is a dimeric and pleiotropic cytokine that plays a crucial role in cellular immunoregulatory responses. As IL-10 binds to its receptors, IL-10Ra and IL-10Rb, it will suppress or induce the downstream cellular ...
Chun-Chun Chang +5 more
doaj +1 more source
Antimicrobial Peptide Modifications against Clinically Isolated Antibiotic-Resistant Salmonella
Molecules, 2021 Antimicrobial peptides are promising molecules to address the global antibiotic resistance problem, however, optimization to achieve favorable potency and safety is required.
Suthee Mangmee +4 more
doaj +1 more source
Structural and biophysical analysis of important biomedical enzymes and nano-architectures [PDF]
, 2008 Dopa decarboxylase (DDC) is an important enzyme in the catecholamine biosynthesis pathways. Catecholamines, e.g., dopamine, serotonin, etc. often are the major neuromodulators or neurotransmitters.
Chattopadhyay, Arundhati
core +1 more source