Results 31 to 40 of about 359,289 (223)
Frontiers in Cell and Developmental Biology, 2020 Pin1 is a peptidyl-prolyl cis-trans isomerase that specifically binds to a phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) motif and catalyzes the cis-trans isomerization of proline imidic peptide bond, resulting in ...
Xiangming Hu +2 more
doaj +1 more source
An in vivo control map for the eukaryotic mRNA translation machinery [PDF]
, 2013 Rate control analysis defines the in vivo control map governing yeast protein synthesis and generates an extensively parameterized digital model of the translation pathway.
Amy Claydon +12 more
core +3 more sources
Symbiotic outcome modified by the diversification from 7 to over 700 nodule specific cysteine rich peptides [PDF]
, 2020 Legume-rhizobium symbiosis represents one of the most successfully co-evolved mutualisms. Within nodules, the bacterial cells undergo distinct metabolic and morphological changes and differentiate into nitrogen-fixing bacteroids.
Achom, Mingkee +4 more
core +1 more source
Improved functionality and potency of next generation BinMLV viral vectors toward safer gene therapy
Molecular Therapy: Methods & Clinical Development, 2021 To develop safer retroviral murine leukemia virus (MLV)-based vectors, we previously mutated and re-engineered the MLV integrase: the W390A mutation abolished the interaction with its cellular tethering factors, BET proteins, and a retargeting peptide ...
Dominique Van Looveren +4 more
doaj +1 more source
Aminoacyl-tRNA-charged eukaryotic elongation factor 1A is the bona fide substrate for Legionella pneumophila effector glucosyltransferases. [PDF]
PLoS ONE, 2011 Legionella pneumophila, which is the causative organism of Legionnaireś disease, translocates numerous effector proteins into the host cell cytosol by a type IV secretion system during infection.
Tina Tzivelekidis +8 more
doaj +1 more source
Spatial Distribution and Ribosome-Binding Dynamics of EF-P in Live
mBio, 2017 In vitro assays find that ribosomes form peptide bonds to proline (Pro) residues more slowly than to other residues. Ribosome profiling shows that stalling at Pro-Pro-X triplets is especially severe but is largely alleviated in Escherichia coli by the ...
Sonisilpa Mohapatra +4 more
doaj +1 more source
Cancer Cell International, 2020 The eukaryotic translation initiation factor 5A1 (eIF5A1) and its homolog eIF5A2 are the only two human proteins containing the unique post-translational modification–hypusination, which is essential for the function of these two proteins.
Gao-Qi Wu, Yan-Ming Xu, Andy T. Y. Lau
doaj +1 more source
Microbial Proteins in Stomach Biopsies Associated with Gastritis, Ulcer, and Gastric Cancer
Molecules, 2022 (1) Background: Gastric cancer (GC) is the fourth leading cause of cancer-related deaths worldwide. Helicobacter pylori infection is a major risk factor, but other microbial species may also be involved.
Shahid Aziz +4 more
doaj +1 more source
HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation. [PDF]
, 2013 The internal ribosome entry site (IRES) of the hepatitis C virus (HCV) drives noncanonical initiation of protein synthesis necessary for viral replication.
A Ben-Shem +68 more
core +1 more source
Frontiers in Endocrinology, 2022 The pituitary is a remarkably dynamic organ with roles in hormone (FSH and LH) synthesis and secretion. In animals with the FecB (fecundity Booroola) mutation, the pituitary experiences hormone fluctuations during the follicular–luteal transition, which ...
Si Chen +8 more
doaj +1 more source