Results 101 to 110 of about 2,203,634 (375)

Computer simulation of the spatial structure of MUC 1 peptides capable of inhibiting apoptosis

Вавиловский журнал генетики и селекции, 2016
Identification of new effective inhibitors of apoptosis is an important task for drug development for treatment of a number diseases including neurogenerative diseases.
N. V. Ivanisenko, I. N. Lavrik, V. A. Ivanisenko   +2 more
doaj   +1 more source

A neutrophil-dependent pathway for the generation of a neutral peptide mediator: partial characterization of components and control by alpha-1-antitrypsin. [PDF]

, 1974
A biologically active neutral peptide mediator is cleaved from a plasma protein substrate by an alpha-1-antitrypsin-inhibitable serine protease apparently residing on the membrane of the human neutrophil. The peptide mediator has an approximate mol wt of
Austen, KF, Goetzl, EJ, Wintroub, BU
core  

Urinary CE-MS peptide marker pattern for detection of solid tumors [PDF]

, 2018
Urinary profiling datasets, previously acquired by capillary electrophoresis coupled to mass-spectrometry were investigated to identify a general urinary marker pattern for detection of solid tumors by targeting common systemic events associated with ...
Belczacka, Iwona, Frantzi, Maria, Jankowski, Vera, Latosinska, Agnieszka, Merseburger, Axel S., Metzger, Jochen, Mischak, Harald, Siwy, Justyna, Vlahou, Antonia   +8 more
core   +2 more sources

A nomenclature system for labeling cyclic peptide fragments

Journal of the American Society for Mass Spectrometry, 1999
A nomenclature system for labeling fragment ions of cyclic peptides is proposed. A fragment ion is labeled with a four-part descriptor for the general formula xnJZ, where x is the designation for the ion (e.g., lower case a or b, as are used for peptide fragments) and n is the number of amino acid residues in the ion.
Lambert C. M. Ngoka, Michael L. Gross
openaire   +3 more sources

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Effect of Anthocyanins Supplementation on Serum IGFBP-4 Fragments and Glycemic Control in Patients with Fasting Hyperglycemia: A Randomized Controlled Trial

Diabetes, Metabolic Syndrome and Obesity, 2020
Liping Yang,1,2 Zhaomin Liu,2 Wenhua Ling,2 Li Wang,1 Changyi Wang,1 Jianping Ma,1 Xiaolin Peng,1 Jianying Chen3 1Center for Chronic Disease Control, Nanshan, Shenzhen, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Food ...
Yang L, Liu Z, Ling W, Wang L, Wang C, Ma J, Peng X, Chen J   +7 more
doaj  

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Functionally important segments in proteins dissected using Gene Ontology and geometric clustering of peptide fragments

Genome Biology, 2008
We have developed a geometric clustering algorithm using backbone φ,ψ angles to group conformationally similar peptide fragments of any length. By labeling each fragment in the cluster with the level-specific Gene Ontology 'molecular function' term of ...
K. Manikandan, D. Pal, S. Ramakumar, N. Brener, S. S. Iyengar, G. Seetharaman   +5 more
semanticscholar   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant\ue2\u80\u93anticoagulant equilibrium toward thrombosis [PDF]

, 2017
Blood coagulation is a finely regulated physiological process culminating with the factor Xa (FXa)-mediated conversion of the prothrombin (ProT) zymogen to active -thrombin (T).
Acquasaliente, Laura, Artusi, Ilaria, De Filippis, Vincenzo, Frasson, Roberta, Peterle, Daniele, Pontarollo, Giulia   +5 more
core   +1 more source