P2‐130: Beta‐amyloid peptide 1‐42 binds to N‐terminal fragment of cytochrome C oxidase subunit 1 (COX1) [PDF]
, 2012 Luis Hernández +4 more
openalex +1 more source
Selective Functionalization of Peptides with Reactive Fragment Ions
Journal of the American Society for Mass SpectrometrySelective binding of highly reactive inorganic fragment ions generated in a mass spectrometer to peptides within surface layers is demonstrated using the sequential mass-selected deposition of the reagents. The closo-dodecaborate fragment ions [B12I11]- and [B12I8S(CN)]- were generated by collision-induced dissociation and bound to three dipeptides ...
Sebastian Kawa +6 more
openaire +2 more sources
Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Advanced Science, EarlyView.Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
Design of Zn‐Binding Peptide(s) from Protein Fragments [PDF]
Ján Michael Kormaník +9 more
openalex +1 more source
NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks
Advanced Science, EarlyView.This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang +10 more
wiley +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Protein-Peptide Complex Prediction through Fragment Interaction Patterns [PDF]
, 2013 Erik Verschueren +4 more
openalex +1 more source
Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity
Advanced Science, EarlyView.We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu +17 more
wiley +1 more source
Direct Identification of Amyloid Peptide Fragments in Human α-Synuclein Based on Consecutive Hydrophobic Amino Acids. [PDF]
ACS Omega, 2020 Chen Y, Peng F, Su T, Yang H, Qiu F.
europepmc +1 more source