Results 91 to 100 of about 433,652 (251)

Large libraries of single-chain trimer peptide-MHCs enable rapid antigen-specific CD8+ T cell discovery and analysis [PDF]

open access: gold, 2022
James R. Heath   +24 more
openalex   +1 more source

Prolyl 4-hydroxlase activity is essential for development and cuticle formation in the human infective parasitic nematode Brugia malayi [PDF]

open access: yes, 2013
Collagen prolyl 4-hydroxylases (C-P4H) are required for formation of extracellular matrices in higher eukaryotes. These enzymes convert proline residues within the repeat regions of collagen polypeptides to 4-hydroxyproline, a modification essential for ...
Alan D. Winter   +40 more
core   +1 more source

On the origin of non-specific binders isolated in the selection of phage display peptide libraries

open access: yesFrontiers in Microbiology
Over the recent decades, phage display has been used successfully to identify a variety of peptides with diagnostic and therapeutic applications. Despite the significant role of this technology in the pharmaceutical industry, the affinity selection of ...
Babak Bakhshinejad   +3 more
doaj   +1 more source

Shotgun Phage Display - Selection for Bacterial Receptins or other Exported Proteins

open access: yesBiological Procedures Online, 2003
Shotgun phage display cloning involves construction of libraries from randomly fragmented bacterial chromosomal DNA, cloned genes, or eukaryotic cDNAs, into a phagemid vector.
Jacobsson Karin   +3 more
doaj   +1 more source

Folding of a single domain protein entering the endoplasmic reticulum precedes disulfide formation [PDF]

open access: yes, 2017
The relationship between protein synthesis, folding and disulfide formation within the endoplasmic reticulum (ER) is poorly understood. Previous studies have suggested pre-existing disulfide links are absolutely required to allow protein folding and ...
Bulleid, Neil J.   +3 more
core   +1 more source

Combination GLP-1 and Insulin Treatment Fails to Alter Myocardial Fuel Selection Versus Insulin Alone in Type 2 Diabetes [PDF]

open access: yes, 2018
Context Glucagon-like peptide-1 (GLP-1) and the clinically available GLP-1 agonists have been shown to exert effects on the heart. It is unclear whether these effects occur at clinically used doses in vivo in humans, possibly contributing to CVD risk ...
Considine, Robert V.   +9 more
core   +1 more source

Identification and characterization of nanobodies targeting the EphA4 receptor [PDF]

open access: yes, 2017
The ephrin receptor A4 (EphA4) is one of the receptors in the ephrin system that plays a pivotal role in a variety of cell-cell interactions, mostly studied during development. In addition, EphA4 has been found to play a role in cancer biology as well as
Chavez-Gutierrez, Lucia   +16 more
core   +2 more sources

Practical computational toolkits for dendrimers and dendrons structure design [PDF]

open access: yes, 2017
Dendrimers and dendrons offer an excellent platform for developing novel drug delivery systems and medicines. The rational design and further development of these repetitively branched systems are restricted by difficulties in scalable synthesis and ...
A Kwok   +52 more
core   +3 more sources

Isolation of a Colon Tumor Specific Binding Peptide Using Phage Display Selection

open access: yesNeoplasia: An International Journal for Oncology Research, 2003
Colorectal cancer is the third most common malignancy in the United States. Improved detection sensitivity of early colorectal neoplasms would have important clinical applications.
Kimberly A. Kelly, David A. Jones
doaj   +1 more source

High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]

open access: yes, 2007
Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B   +11 more
core  

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